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CTRI Number  CTRI/2026/01/100634 [Registered on: 09/01/2026] Trial Registered Prospectively
Last Modified On: 08/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Single Arm Study 
Public Title of Study   Managing Rheumatoid Arthritis with Individualized Homeopathic Treatment: Case Studies 
Scientific Title of Study   Management Of Rheumatoid Arthritis By Individualised Homoeopathic Treatment Based on miasmatic Evolution:A Case Series. 
Trial Acronym  Nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Ankita Sandeep Patil  
Designation  Pg part 1 scholar  
Affiliation  Motiwala Homoeopathic National Medical College  
Address  Department of Organon, Motiwala (National) Homoeopathic Medical college and hospital, Dhruv Nagar, Satpur Colony.

Nashik
MAHARASHTRA
422012
India 
Phone  8600537836  
Fax    
Email  aspatil0507@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Gayatri Nimbhore  
Designation  Professor  
Affiliation  Motiwala Homoeopathic National medical college  
Address  Department of Organon, Motiwala (National) Homoeopathic Medical college and hospital, Dhruv Nagar, Satpur Colony.

Nashik
MAHARASHTRA
422012
India 
Phone  9405308984  
Fax    
Email  barigayatri1@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Gayatri Nimbhore  
Designation  Professor  
Affiliation  Motiwala Homoeopathic National medical college  
Address  Department of Organon, Motiwala (National) Homoeopathic Medical college and hospital, Dhruv Nagar, Satpur Colony.

Nashik
MAHARASHTRA
422012
India 
Phone  9405308984  
Fax    
Email  barigayatri1@gmail.com  
 
Source of Monetary or Material Support  
Department of Organon, Motiwala (National) Homoeopathic Medical college and hospital, Dhruv Nagar, Satpur Colony,Nashik,422012,Maharashtra,India. 
 
Primary Sponsor  
Name  Dr Ankita Sandeep Patil  
Address  Department of Organon, Motiwala (National) Homoeopathic Medical college and hospital, Dhruv Nagar, Satpur Colony,Nashik,422012,Maharashtra,India 
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Ankita S Patil   Motiwala National Homoeopathic Medical College and Hospital  Department Of Organon, dhruv nagar, satpur colony, nashik,422012
Nashik
MAHARASHTRA 
8600537836

aspatil0507@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethical cell motiwala homoeopathicmedical college   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M059||Rheumatoid arthritis with rheumatoid factor, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  NIL  NIL 
Intervention  To analyze the role of individualized homoeopathic treatment in management of Rheumatoid Arthritis along with miasmatic analysis.   After homeopathic case taking individualized homeopathic medicine will be given. Follow up of the case will be taken after 15 days or as per required. Dose and repetition will be done according to that case. Assessment will be done with help of PROM AND PREM Scale pre and post homoeopathic treatment. 
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  80.00 Year(s)
Gender  Both 
Details  1. Pre-diagnosed patients of Rheumatoid arthritis with ra factor test positive and more than 14 IU/ml more.
2. Patients of both gender.
3. Patients of all ages.  
 
ExclusionCriteria 
Details  Severe cases of Rheumatoid arthritis requring Hospitalization due to emergency crisis. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Miasmatic analysis of Rheumatoid arthritis patient  baseline 
 
Secondary Outcome  
Outcome  TimePoints 
improvement in daily functioning, reduction in pain episodes & flare-ups, decreased dependency on other medicines, & overall well-being.  After 6 month 
 
Target Sample Size   Total Sample Size="30"
Sample Size from India="30" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   19/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Title
Management of Rheumatoid Arthritis by Individualised Homoeopathic Treatment Based on Miasmatic Evolution: A Case Series Study.

Introduction
Rheumatoid arthritis (RA) is a chronic systemic autoimmune inflammatory disorder characterized by symmetrical joint involvement, pain, stiffness, deformities, and functional disability. Conventional management provides symptomatic relief but is often associated with adverse effects and does not prevent long-term disease progression. Homoeopathy offers an individualized, holistic approach with emphasis on totality of symptoms and miasmatic background, making it a potential alternative for long-term management of RA.

Research Gap
Limited literature on the role of miasmatic analysis in RA

Lack of studies on individualized homoeopathic treatment in RA

Insufficient evidence on long-term outcomes of homoeopathic management

Poor understanding of psychological and miasmatic influences in RA

Need for systematic clinical evaluation through case series

Review of Literature (Brief)
RA is a chronic inflammatory polyarthritis with extra-articular manifestations and progressive joint damage. It commonly affects women aged 40–60 years. Autoimmunity, genetic predisposition, cytokine imbalance, and environmental factors play a key role in pathogenesis. Homoeopathic literature considers RA as a degenerative disease arising from mixed chronic miasms—mainly psora, sycosis, and syphilis. Previous studies suggest symptomatic improvement with individualized homoeopathic treatment, though evidence remains limited.

Research Question
What is the impact of miasmatic analysis–based individualized homoeopathic management in patients with Rheumatoid Arthritis?

Hypothesis
H1 (Alternative): Miasmatic analysis–based homoeopathic management significantly improves clinical symptoms of Rheumatoid Arthritis.

H0 (Null): Miasmatic analysis–based homoeopathic management has no significant impact on clinical symptoms of Rheumatoid Arthritis.

Objectives
Primary Objective

To analyze the role of individualized homoeopathic treatment in the management of Rheumatoid Arthritis with miasmatic analysis.

Secondary Objectives

To evaluate the efficacy of homoeopathic medicines in reducing pain, inflammation, and improving mobility.

To assess the long-term impact of miasmatic homoeopathic treatment on disease progression and overall health.

Methodology
Study Design: Case series study

Study Setting: Motiwala Homoeopathic Medical College OPD, peripheral OPDs, and camps

Sample Size: 30 cases

Sampling Technique: Simple random sampling

Study Duration: 18 months

Duration per Case: 6 months to 1 year

Follow-up: Every 15 days or as required

Inclusion Criteria
Pre-diagnosed RA patients with RA factor >14 IU/ml

Patients of all ages and both genders

Exclusion Criteria
Severe RA requiring hospitalization

Patients on other systems of treatment

Irregular or non-cooperative patients

Assessment Tools
Homoeopathic case taking proforma

PROM & PREM scale

Visual Analogue Scale (VAS) for pain

Data Analysis
Data will be analyzed using appropriate statistical methods (paired t-test / Wilcoxon test) with significance set at p < 0.05.

Expected Outcome
The study aims to demonstrate that individualized homoeopathic treatment based on miasmatic analysis can effectively reduce symptoms, improve quality of life, and help in long-term management of Rheumatoid Arthritis.
 
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