After institutional ethical committee clearance, patients will be selected for the study based on inclusion and exclusion criteria,  and informed written consent/ assent will be obtained from the parents/ child during the pre-anaesthesia check-up.

Patients will be assessed before the procedure in pre-anaesthetic check-up (PAC) visit and  thorough history taking and examination will be done. Standard pre-operative nil per oral advise will be given.

In the OT, a standard inhalational induction of anaesthesia, (50% oxygen + 50% nitrous oxide and 2-8 % sevoflurane in increments) will be performed. ASA standard monitors (Electrocardiography, Pulse oximetry, Non-invasive blood pressure) and processed EEG monitor (to assess depth of anaesthesia) will be connected and baseline values recorded. IV cannula will be secured under inhalational anaesthesia. Nitrous oxide and sevoflurane will be turned off once iv cannula is secured. Inj Fentanyl 2 mcg/kg given and TIVA-TCI Eleveld model of propofol will be started at effect site concentration (Ce) 1 mcg/mL and titrated at increments of 0.5 mcg/mL to target BIS value between 40-60.

 inj atracurium 0.5 mg/kg IV will be given and after 4 min endotracheal intubation will be performed with appropriate sized endotracheal tube. Inj.Morphine IV at dose of 0.05 mg /kg bolus will be administered before incision and boluses of 0.025 mg/kg will be repeated if required to a maximum dose of 0.1 mg/kg. All patients will receive Inj.Dexamethasone 0.2 mg/kg, Inj.Paracetamol 15 mg/kg, Ibugesic 5 mg/kg for analgesia.

ECG, HR, MAP, Saturation (SpO2), end tidal co2 will be monitored continuously throughout the surgery and anaesthesia as per the standard intraoperative monitoring.

At the end of surgery, Inj.Ondansetron 0.1mg/kg will be given for postoperative nausea and vomiting prophylaxis. Then TIVA –TCI will be discontinued (i.e effect site concentration (Ce) set to 0 mcg/ml) and patient will be extubated once extubation criteria is met.

Values noted:

·      Ce value at maintenance of anaesthesia (mcg/ml)

·      Ce at return of responsiveness (RoR) (RoR is defined as awakening to verbal command or slight tapping).

·      the time taken for RoR after discontinuing propofol TCI.

·      the total propofol consumption (mg/kg/hr)

·      the total opioid consumption.

The patient will be shifted to post anaesthesia care unit and monitored for 60 minutes. The occurrence of following events will be documented:

·      Respiratory adverse events (laryngospasm, bronchospasm, cough, breath holding, airway obstruction, desaturation < 92%)

·      Sedation score (PASS – Paediatric Analog Sedation Score),

·      Emergence delirium score (PAED scale)

·      Postoperative nausea and vomiting (PONV)

·      Pain score (FACES scale for 4-7 years old and NRS scale for 7-16 years)