Coronary revascularization surgery, a common procedure for the treatment of coronary artery disease, is traditionally associated with significant postoperative pain and opioid consumption. However, the use of opioids in the perioperative period can lead to a range of adverse effects, including respiratory depression, sedation, and the development of chronic opioid use. (Schwenk et al., 2018) To address these concerns, researchers have explored the feasibility and efficacy of opioid-free anesthesia for coronary revascularization surgery and its impact on postoperative recovery.

One of the key potential benefits of opioid-free anesthesia is the reduction in opioid consumption during the perioperative period. Studies have shown that the use of alternative analgesic agents, such as ketamine, can effectively manage pain without the need for high doses of opioids. Ketamine, an N-methyl-D-aspartate receptor antagonist, has been found to have analgesic properties and can be used in combination with other non-opioid medications to provide effective pain control. (Schwenk et al., 2018) Furthermore, the use of opioid-free anesthesia may have a positive impact on postoperative recovery, as it can reduce the incidence of opioid-related side effects, such as respiratory depression, sedation, and the development of chronic opioid use. (Hah et al., 2021). In a case report, researchers described the successful use of oral ketamine to treat opioid-resistant postoperative pain, highlighting the potential of this approach to reduce opioid requirements and improve pain management (Friedman et al., 2001).

In summary, the transition to opioid-free anesthesia for coronary revascularization surgeries introduces significant benefits that warrant further exploration and implementation. This approach mitigates the risks associated with opioid use, such as addiction potential and adverse side effects, while still addressing the critical need for effective pain management. Additionally, the importance of a thorough preoperative evaluation ties closely into the decision-making processes around anesthesia options, emphasizing the need for tailored approaches in clinical settings (Adams et al.). Ultimately, embracing opioid-free techniques not only aligns with emerging standards