INTRODUCTION:-

Psoriasis is a chronic, immune-mediated skin disorder marked by erythematous plaques and scaling, significantly affecting quality of life. The exact etiology of Psoriasis is still unknown, but it is believed to have a genetic component. Multifactorial inheritance, most likely a familial history of psoriasis, is found in 30% of patients. It is mediated by T-Cells. Psoriasis is seen worldwide in all races and both sexes with a prevalence from 0.1 to 3%. (1) It is associated with systemic inflammation. The blood levels of various inflammatory markers are increased in psoriasis. One of them is high-sensitivity C-reactive protein (hsCRP). The serum level of hs-CRP is increased in many inflammatory diseases like psoriasis, cardiovascular diseases, infections, arthritis, and others. In psoriasis, hsCRP is a reliable biomarker of systemic inflammatory burden, with elevated levels correlating with disease severity, beyond its role in tracking skin involvement. It also reflects the risk of associated comorbidities like cardiovascular disease and metabolic syndrome. The high-sensitivity CRP (hsCRP) test accurately measures low levels of C-reactive protein to identify low but persistent levels of inflammation. As a diagnostic and prognostic tool, hsCRP is valuable for monitoring therapeutic outcomes and bridging clinical symptoms with underlying systemic pathology. In Ayurveda, the nearest entity to psoriasis is Kitibha, a Vata-Kapha predominant skin disease. Treatment focuses on balancing doshas and the removal of the morbid doshas. the treatment

principle includes repeated Shodhana, Bahirparimarjana Chikitsa, and Shamana medications. Key interventions include Vamana (therapeutic emesis), Kashayadhara (herbal decoction pouring), and Manibhadra Gula, a classical polyherbal formulation known for its detoxifying and skin-healing properties. In the present study, we are planning to determine the serum level of hs-CRP in psoriasis to its PASI score, which is a subjective method to determine the severity of the disease, when managed with Kashaya Dhara, Vamana, and Manibhadra Gula as Shamana medication.hs- CRP is an objective and more reliable method, and to have a better idea of systemic inflammatory process caused by psoriasis. 

This open-label, single-arm study evaluates the effectiveness of this Panchakarma protocol in managing Kitibha (psoriasis), using PASI score and hsCRP levels as clinical and biochemical outcome measurements.

NEED OF THE STUDY:-

Psoriasis is a chronic, immune-mediated skin condition linked to systemic inflammation and reduced quality of life. High-sensitivity C-reactive protein (hsCRP), a marker of low-grade inflammation, is often elevated in psoriatic patients and offers greater sensitivity than conventional CRP tests. While CRP is a simple, cost-effective, and known prognostic marker, even though the data on hsCRP in psoriasis are limited. Ayurvedic medicine shows promise in

managing psoriasis, but its effect on inflammatory markers like hsCRP remains underexplored. This study investigates the impact of an Ayurvedic treatment protocol on hsCRP levels, aiming to assess its potential in monitoring and managing systemic inflammation in psoriasis.

METHODOLOGY:

This study is a prospective, single-arm interventional clinical trial with an open-label design, conducted over a period of 2.5 years on diagnosed cases of psoriasis, in both outpatient and inpatient departments (OPD & IPD) of the All India Institute of Ayurveda (AIIA).