CTRI

FULL DETAILS (Read-only) -> Click Here to Create PDF for Current Dataset of Trial

CTRI Number

CTRI/2025/09/094663 [Registered on: 12/09/2025] Trial Registered Prospectively

Last Modified On:

21/08/2026

Post Graduate Thesis

Yes

Type of Trial

Interventional

Type of Study

Ayurveda

Study Design

Randomized, Parallel Group, Active Controlled Trial

Public Title of Study

Study on the effect of Durdhuradi Taila in managing Dandruff (Darunaka) compared to Standard Therapy

Scientific Title of Study

Standard controlled clinical evaluation of Durdhuradi Taila in Darunak

Trial Acronym

NIL

Secondary IDs if Any

Secondary ID	Identifier
NIL	NIL

Details of Principal Investigator or overall Trial Coordinator (multi-center study)

Name	Aditi Bhatt
Designation	PG Scholar
Affiliation	Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan
Address	OPD-3, Department of Shalakya Tantra, Patanjali Ayurved hospital, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar Hardwar UTTARANCHAL 249405 India
Phone	7454873453
Fax
Email	aditibhatt922@gmail.com

Details of Contact Person
Scientific Query

Name	Dr Amit Kumar Agrawal
Designation	Associate Professor
Affiliation	Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan
Address	OPD-3, Department of Shalakya Tantra, Patanjali Ayurved hospital, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar Hardwar UTTARANCHAL 249405 India
Phone	9411551545
Fax
Email	agrawal.amitkumar308@gmail.com

Details of Contact Person
Public Query

Name	Aditi Bhatt
Designation	PG Scholar
Affiliation	Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan
Address	OPD-3, Department of Shalakya Tantra, Patanjali Ayurved hospital, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar Hardwar UTTARANCHAL 249405 India
Phone	7454873453
Fax
Email	aditibhatt922@gmail.com

Source of Monetary or Material Support

Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar,Uttarakhand,India Pin code 249405

Primary Sponsor

Name	Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar
Address	Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar,Uttarakhand, India 249405
Type of Sponsor	Private medical college

Details of Secondary Sponsor

Name	Address
NIL	NIL

Countries of Recruitment

India

Sites of Study

No of Sites = 1
Name of Principal Investigator	Name of Site	Site Address	Phone/Fax/Email
Dr Aditi Bhatt	Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar	OPD-3, Department of Shalakya Tantra, Patanjali Ayurved hospital, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar Hardwar UTTARANCHAL	7454873453 aditibhatt922@gmail.com

Details of Ethics Committee

No of Ethics Committees= 1
Name of Committee	Approval Status
Institutional Ethics Committee,Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan,Haridwar,249405	Approved

Regulatory Clearance Status from DCGI

Status

Not Applicable

Health Condition / Problems Studied

Health Type	Condition
Patients	(1) ICD-10 Condition:L210\|\|Seborrhea capitis. Ayurveda Condition: DARUNAKAH,

Intervention / Comparator Agent

sno	Intervention/Comparator	Type	Drug-Type	Procedure Name	Details
1	Comparator Arm (Non Ayurveda)		-	Ketoconazole shampoo	Dosage form: Topical shampoo Strength: 2% w/v Indication in India: Dandruff/seborrheic dermatitis of the scalp Route of administration: Topical (scalp application) Dose and regimen : Apply 10-15 mL, twice weekly for 30 days ( 8 applications)
2	Intervention Arm	Procedure	-	mUrdhatailam/ Sirastailam, मूर्धतैलम्/ शिरस्तैलम्	(Procedure Reference: Su.Chi.24/30, Procedure details: Poorva Karma-Preparation of materials Medicated oil,Droni table or chair with head support Oil heating apparatus for maintaining lukewarm temperature Pradhana Karma-Shiroabhyanga from Durdhuradi Taila for 10 minutes (400 Matra Kala) in night, twice a week, for 30 days(8 Applications). Paschat Karma-Hair wash with lukewarm water in next morning. ) (1) Medicine Name: Durdhuradi Taila, Reference: Sahasra Yogam Taila Prakaran, Route: Topical, Dosage Form: Taila, Dose: 15(ml), Frequency: od, Duration: 8 Days

Inclusion Criteria

Age From	10.00 Year(s)
Age To	60.00 Year(s)
Gender	Both
Details	1.The patients presenting with classical features of Darunaka as mentioned in diagnostic criteria will be selected irrespective of Sex and Socioeconomic status. Diagnostic Criteria: 1.Itching at scalp (Kandu) 2. Diffuse hair fall (Keshachyuti) 3. Roughness of scalp (Rukshata) 4.Scaling of scalp skin (Twaksphutana) 2.Age group between 10-60 years.

ExclusionCriteria

Details

1.Patient below the age of 10 and above 60yrs.
2.Associated with other dermatological conditions such as pityriasis steatoides, psoriasis, eczema etc.
3. Patients having Chronic infectious diseases (tuberculosis, leprosy etc.) and metabolic diseases (DM, hypothyroidism etc.).
4. Patient suffering from cancer and taking chemotherapy and radiotherapy.
5. Other types of Kapala gata roga.
6. Conditions in which head wash is restricted like Ardita,injuries to scalp.

Method of Generating Random Sequence

Computer generated randomization

Method of Concealment

On-site computer system

Blinding/Masking

Open Label

Primary Outcome

Outcome	TimePoints
Assessment will be done on the basis of subjective parameter Itching at scalp (Kandu) Diffuse hair fall (Keshachyuti) Roughness of scalp(Rukshata) Scaling of scalp skin (Twaksphutana)	Baseline before treatment End of treatment 4 weeks

Secondary Outcome

Outcome	TimePoints
Assessment will be done on the basis of subjective parameter Itching at scalp (Kandu) Diffuse hair fall (Keshachyuti) Roughness of scalp(Rukshata) Scaling of scalp skin (Twaksphutana)	Baseline before treatment End of treatment 4 weeks

Target Sample Size

Total Sample Size="100"
Sample Size from India="100"
Final Enrollment numbers achieved (Total)= "100"
Final Enrollment numbers achieved (India)="100"

Phase of Trial

Phase 2

Date of First Enrollment (India)

23/09/2025

Date of Study Completion (India)

19/05/2026

Date of First Enrollment (Global)

Date Missing

Date of Study Completion (Global)

Date Missing

Estimated Duration of Trial

Years="1"
Months="6"
Days="0"

Recruitment Status of Trial (Global)

Not Applicable

Recruitment Status of Trial (India)

Completed

Publication Details
Modification(s)

article is published in WJPR with title of An ayurvedic review of darunak vyadhi with special reference to pityriasis sicca dandruff.published on 16 feb 2026.

Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?

Response - NO

Brief Summary
Modification(s)

This study was a standard controlled clinical evaluation of Durdhuradi Taila in Darunak. The study was conducted on 100 patients who were recruited from the OPD/IPD of the Department of Shalakya Tantra, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar.

The selected patients were divided into two groups. Group A consisted of 50 patients who were administered Durdhuradi Taila topically, while Group B consisted of 50 patients who were administered Ketoconazole shampoo topically. The treatment was administered for the prescribed duration, followed by two follow-up assessments at an interval of one month after completion of treatment.

The assessment was carried out on the basis of subjective parameters, as described earlier, to evaluate the clinical efficacy of the respective interventions in the management of Darunak.