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CTRI Number  CTRI/2026/03/106524 [Registered on: 19/03/2026] Trial Registered Prospectively
Last Modified On: 13/03/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Single Arm Study 
Public Title of Study   Effect of selected Homoeopathic medicines (Asterias Rubens Azadirachta Indica Eugenia Jambos and Juglans Regia) in the management of Acne. 
Scientific Title of Study   Exploring efficacy of Lesser known Homoeopathic Therapeutics (Asterias Rubens, Azadirachta Indica, Eugenia Jambos & Juglans Regia) in management of Acne : A clinical study 
Trial Acronym   
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Pritikaben Maheshkumar Patel 
Designation  MD Scholar Part 2 
Affiliation  S. S. Agrawal Homoeopathic Medical College And General Hospital, Navsari 
Address  S. S. Agrawal Homoeopathic Medical College And General Hospital, Navsari Near Devina Park Society Gandevi Road Navsari Gujarat, 396445, PG Division, 5th Floor Homoeopathic POM Department.

Navsari
GUJARAT
396445
India 
Phone  7567599946  
Fax    
Email  pritikapatel95@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Endreshkumar  
Designation  Associate Professor Of Practice of Medicine 
Affiliation  S. S. Agrawal Homoeopathic Medical College And General Hospital, Navsari 
Address  S. S. Agrawal Homoeopathic Medical College And General Hospital, Navsari Near Devina Park Society Gandevi Road Navsari Gujarat, 396445, PG Division, 5th Floor Homoeopathic POM Department.

Navsari
GUJARAT
396445
India 
Phone  9672519750  
Fax    
Email  endreshkatiyar@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Endreshkumar  
Designation  Associate Professor Of Practice of Medicine 
Affiliation  S. S. Agrawal Homoeopathic Medical College And General Hospital, Navsari 
Address  S. S. Agrawal Homoeopathic Medical College And General Hospital, Navsari Near Devina Park Society Gandevi Road Navsari Gujarat, 396445, PG Division, 5th Floor Homoeopathic POM Department.

Navsari
GUJARAT
396445
India 
Phone  9672519750  
Fax    
Email  endreshkatiyar@gmail.com  
 
Source of Monetary or Material Support  
S. S. Agrawal Homoeopathic Medical College and General Hospital, Navsari 
 
Primary Sponsor  
Name  S. S. Agrawal Homoeopathic Medical College and General Hospital, Navsari 
Address  Near Devina Park Society, Gandevi Road, Navsari, 396445 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Pritikaben Maheshkumar Patel   S. S. Agrawal Homoeopathic Medical College and General Hospital, Navsari, Gujarat  Medicine OPD, Ground floor, S.S Agrawal Homoeopathic Medical College and General Hospital near devina park society gandevi road Navsari, Gujarat - 396445
Navsari
GUJARAT 		 7567599946

pritikapatel95@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
INSTITUTIONAL ETHICS COMMITTEE, S.S. AGRAWAL HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: L709||Acne, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Asterias Rubens, Azadirachta Indica, Eugenia Jambos & Juglans Regia  Homoeopathic medicines Asterias Rubens, Azadirachta Indica, Eugenia Jambos & Juglans Regia will be prescribe on the basis of individual totality of symptoms. The dose and potency will be selected on the basis of the patient susceptibility and necessity of case. Administration will be through oral route and follow up will be taken in every 2-3 weeks. 
Comparator Agent  Nil  Nil 
 
Inclusion Criteria  
Age From  14.00 Year(s)
Age To  50.00 Year(s)
Gender  Both 
Details  According to diagnostic criteria patient of both sexes & patient’s age above 14 years to 50 years cases will be included.
 
 
ExclusionCriteria 
Details  Patients of age group below 14 years and above 50 years, Patients whose GAGS scale score is more than 39 will be excluded, Patients who are pregnant and lactating will be also excluded. 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Change in Global Acne Grading System (GAGS) score from baseline after treatment with selected homoeopathic medicines in patients with Acne vulgaris and Acne rosacea.  6 months 
 
Secondary Outcome  
Outcome  TimePoints 
To compare the symptomatic relief before and after treatment with the help of GAGS scale.   9 month 
 
Target Sample Size   Total Sample Size="80"
Sample Size from India="80" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 2/ Phase 3 
Date of First Enrollment (India)   25/03/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="9"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   This dissertation titled “Exploring efficacy of Lesser known Homoeopathic Therapeutics (Asterias Rubens, Azadirachta Indica, Eugenia Jambos & Juglans Regia) in management of Acne: A Clinical Study” is submitted to Veer Narmad South Gujarat University, Surat, as partial fulfillment for the degree of MD (Hom.) in Practice of Medicine. Acne is a chronic inflammatory disorder of the pilosebaceous unit commonly affecting adolescents and young adults, significantly impacting psychological and social well-being. Conventional treatments, though effective, are often associated with adverse effects. Homoeopathy offers a holistic and individualized approach; however, lesser-known remedies such as Asterias Rubens, Azadirachta Indica, Eugenia Jambos, and Juglans Regia, though used in clinical practice, lack sufficient scientific evaluation. This prospective experimental clinical study will be conducted at S.S. Agrawal Homoeopathic Medical College and Hospital, Navsari, including 80 cases selected through purposive sampling. Diagnosed cases of Acne Vulgaris and Acne Rosacea above 14 years of age will be assessed using the Global Acne Grading System (GAGS) before and after treatment to evaluate improvement. The study aims to determine the clinical efficacy of these lesser-known homoeopathic medicines in reducing acne severity and associated symptoms, thereby contributing evidence-based support to homoeopathic dermatological practice. 
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