| CTRI Number |
CTRI/2025/09/094636 [Registered on: 11/09/2025] Trial Registered Prospectively |
| Last Modified On: |
11/09/2025 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Homeopathy |
| Study Design |
Single Arm Study |
|
Public Title of Study
|
Role of Homoeopathic medicines in Depression of adults |
|
Scientific Title of Study
|
A Prospective Interventional Clinical Study on the effect of Individualized Homoeopathic Medicine in the Management of Depressive Mood Disorder using Homoeopathic Medical Repertory by Robin Murphy |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr Vibhor Gupta |
| Designation |
PG Scholar |
| Affiliation |
Bakson Homoeopathic Medical College and Hopsital |
| Address |
Room no B14
Department of Homoeopathic Repertory and Case taking
36 B Knowledge Park
Phase 1
Bakson Homoeopathic Medical College and Hospital
Gautam Buddha Nagar
UTTAR PRADESH
201306
India |
| Phone |
7003601393 |
| Fax |
|
| Email |
vibhorhomoeopath@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr Aditi Goyal |
| Designation |
Guide and Head of Department of Homoeopathic Repertory and Case Taking |
| Affiliation |
Bakson Homoeopathic Medical College and Hopsital |
| Address |
Room no B15
Department of Homoeopathic Repertory and Case taking
36 B Knowledge Park
Phase 1
Bakson Homoeopathic Medical College and Hospital
Gautam Buddha Nagar
UTTAR PRADESH
201306
India |
| Phone |
9910797598 |
| Fax |
|
| Email |
draditigoyal19@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Dr Aditi Goyal |
| Designation |
Guide and Head of Department of Homoeopathic Repertory and Case Taking |
| Affiliation |
Bakson Homoeopathic Medical College and Hopsital |
| Address |
Room no B15
Department of Homoeopathic Repertory and Case taking
36 B Knowledge Park
Phase 1
Bakson Homoeopathic Medical College and Hospital
Gautam Buddha Nagar
UTTAR PRADESH
201306
India |
| Phone |
9910797598 |
| Fax |
|
| Email |
draditigoyal19@gmail.com |
|
|
Source of Monetary or Material Support
|
| Bakson Homoeopathic Medical College and Hospital
Room no G22
Principal Office
Ground floor
36B Knowledge Park
Phase 1
Greater Noida
Uttar Pradesh |
|
|
Primary Sponsor
|
| Name |
Bakson Homoeopathic Medical College and Hospital |
| Address |
Room no G22
Principal Office
Ground floor
Plot no 36B
Knowledge Park Phase 1
Greater Noida
Uttar Pradesh |
| Type of Sponsor |
Private medical college |
|
|
Details of Secondary Sponsor
|
| Name |
Address |
| NIL |
Not Applicable |
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 2 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Vibhor Gupta |
Bakson Homoeopathic Medical College and Hospital |
OutPatient Department
Medicine
Room no 1
Ground Floor
Plot no 36B Knowledge Park
Phase1
Greater Noida
Uttar Pradesh
Gautam Buddha Nagar
UTTAR PRADESH |
7003601393
vibhorhomoeopath@gmail.com |
| Dr Vibhor Gupta |
Dr D P Rastogi Central Research Instiute of Homoeopathy |
General Out Patient Department
Room No 109
Ground Floor
Opp HCL Sector 24
Noida
Uttar Pradesh
Gautam Buddha Nagar
UTTAR PRADESH |
7003601393
vibhorhomoeopath@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 2 |
| Name of Committee |
Approval Status |
| Institutional Ethics Committee Bakson Homoeopathic Medical College |
Approved |
| Kendriya Homoeopathic Anusandhan Parishad |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: F30-F39||Mood [affective] disorders, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Individualized Homoeopathic Medicine |
Pill form of administration
Oral route of administration
30 pill size
In Centesimal scale
First dose after case taking
Repetition of dose according to follow up |
| Comparator Agent |
NIL |
NIL |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
59.00 Year(s) |
| Gender |
Both |
| Details |
Patients aged 18 to 59 years
Becks Depression Inventory score should be between 11 to 30
Patients with stable mild to moderate symptoms of low mood irritability anxiety mood swings
One month washout period will be given for patients previously taking allopathic medicines
|
|
| ExclusionCriteria |
| Details |
Patients currently on allopathic psychotropic medications like antidepressants antipsychotics or other therapies for mood disorders
Pregnant and lactating women
Patients with neurological diseases like epilepsy dementia
Patients diagnosed with substance abuse disorder
Patients with severe chronic systemic illness like uncontrolled DM Hypertension etc
Patients with severe psychiatric illness like severe depression dysthymia schizophrenia bipolar disorder with psychosis persistent mood disorders and mania are excluded
|
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
| Assessing the effect of Individualized Homoeopathic Medicine prescribed using Robin Murphys Homoeopathic Medical Repertory in the management of depressive mood disorder using Hamilton Depression Rating Scale |
16 months study
6 month enrollment
6 month follow up
2 month data analysis
2 month report writing
Becks depression rating scale to be used at baseline
Hamilton depression rating scale to be used at baseline 3 month and 6 month
Statistical analysis to be done based on the data of baseline 3 month and 6 month |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| Compare the pre and post treatment mood scores to determine the statistical significance of improvement |
16 months study
6 month enrollment
6 month follow up
2 month data analysis
2 month report writing
Hamilton depression rating scale to be used at baseline 3 month and 6 month
Statistical analysis to be done based on the data of baseline 3 month and 6 month |
|
|
Target Sample Size
|
Total Sample Size="35"
Sample Size from India="35"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
22/09/2025 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1"
Months="4"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
This study aims to review the effect of Individualized Homoeopathic Medicine in the management of mild to moderate depressive mood disorders in 35 participants using Homoeopathic Medical Repertory by Robin Murphy with the help of Becks Depression Inventory scale for diagnosis at baseline and Hamilton Depression scale to be used at baseline 3rd month and 6th month and the outcome will be statistically assessed with repeated measure ANOVA |