Background: Adenoid hypertrophy (AH) is one of the most common pediatric ENT disorders, affecting 20–40% of children worldwide and up to 40% in India. It often leads to nasal obstruction, sleep-disordered breathing, recurrent infections, and impaired quality of life. Conventional treatments such as corticosteroids provide only temporary relief, while adenoidectomy carries risks of surgical complications and recurrence. Homeopathy, particularly Agraphis nutans, has shown potential in managing AH, but direct comparative studies with individualized homeopathic prescriptions are lacking.

Aim: To compare the efficacy of individualized homeopathic medicine with Agraphis nutans 6C in children with Grade I and Grade II adenoid hypertrophy.

Methods: This is a randomized, single-blind, controlled clinical trial conducted at Bharati Vidyapeeth Homoeopathic Medical College and Hospital, Pune. Children aged 4–12 years with Grade I or II AH confirmed by nasal endoscopy and persistent symptoms for over three months will be included. Participants will be randomized into two groups:

Primary outcome will be improvement in quality of life using the OSA-18 questionnaire. Secondary outcomes include reduction in adenoid size (via nasal endoscopy) and changes in severity scores. Data will be analyzed using appropriate statistical methods, primarily paired t-test.

Expected Outcomes:

The study seeks to generate evidence regarding the comparative effectiveness of individualized homeopathy and Agraphis nutans 6C in managing pediatric AH, offering a potential non-invasive and safe alternative to conventional therapy.

Conclusion:This trial will address the existing research gap and may guide clinicians and parents toward safer, individualized treatment strategies for pediatric adenoid hypertrophy.