| CTRI Number |
CTRI/2025/09/093962 [Registered on: 01/09/2025] Trial Registered Prospectively |
| Last Modified On: |
30/08/2025 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Physiotherapy (Not Including YOGA) |
| Study Design |
Non-randomized, Active Controlled Trial |
|
Public Title of Study
|
Effectiveness of closed kinetic verses open kinetic chain exercises |
|
Scientific Title of Study
|
Effectiveness of closed kinetic chain exercises verses open kinetic chain exercise on reducing pain, improving functional activity and muscle strength in patients with unilateral patellofemoral pain syndrome - comparative study |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Lavanya M |
| Designation |
PG Resident |
| Affiliation |
College of Physiotherapy, Sri Ramakrishna Institute Of Paramedical Science |
| Address |
3rd Floor, 2nd Room, College of Physiotherapy, Sri Ramakrishna Institute Of Paramedical Science, 395, Sarojini Naidu road, Sidhapudur, coimbatore
Coimbatore
TAMIL NADU
641044
India |
| Phone |
8825639011 |
| Fax |
|
| Email |
lavanya10122000@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
V S Seetharaman |
| Designation |
Principal |
| Affiliation |
College of Physiotherapy, Sri Ramakrishna Institute Of Paramedical Science |
| Address |
3rd Floor, 2nd Room, College of Physiotherapy, Sri Ramakrishna Institute Of Paramedical Science, 395, Sarojini Naidu road, Sidhapudur, coimbatore
Coimbatore
TAMIL NADU
641044
India |
| Phone |
9842744406 |
| Fax |
|
| Email |
principal@sripmsphysio.ac.in |
|
Details of Contact Person
Public Query
|
| Name |
V S Seetharaman |
| Designation |
Principal |
| Affiliation |
College of Physiotherapy, Sri Ramakrishna Institute Of Paramedical Science |
| Address |
3rd Floor, 2nd Room, College of Physiotherapy, Sri Ramakrishna Institute Of Paramedical Science, 395, Sarojini Naidu road, Sidhapudur, coimbatore
Coimbatore
TAMIL NADU
641044
India |
| Phone |
9842744406 |
| Fax |
|
| Email |
principal@sripmsphysio.ac.in |
|
|
Source of Monetary or Material Support
|
| College of Physiotherapy, Sri Ramakrishna Institute Of Paramedical Science, coimbatore, Tamil Nadu, India, postal code-641044, |
|
|
Primary Sponsor
|
| Name |
Lavanya M |
| Address |
3rd Floor, 2nd Room, College of Physiotherapy, Sri Ramakrishna Institute Of Paramedical Sciences, 395, Sarojini Naidu road, Sidhapudur, coimbatore-641044 |
| Type of Sponsor |
Other [Self ] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| VS Seetharaman |
Sri Ramakrishna Hospital (Multi speciality) |
Sri Ramakrishna Hospital (Multi speciality) 395, Sarojini Naidu road, Sidhapudur, Coimbatore-641044
Coimbatore
TAMIL NADU |
9842744406
principal@sripmsphysio.ac.in |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| SRI RAMAKRISHNA HOSPITAL ETHICAL COMMITTEE |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: M222||Patellofemoral disorders, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Closed Kinetic Chain Exercises |
Wall Squat and Stretching |
| Comparator Agent |
Open kinetic Chain Exercises |
Muncie Method And Stretching |
|
|
Inclusion Criteria
|
| Age From |
20.00 Year(s) |
| Age To |
40.00 Year(s) |
| Gender |
Both |
| Details |
Normal BMI, Mild to moderate (3-5) Visual Analogue Scale (VAS) score without medication, Lysholm knee scoring (grade- 65 to 83 points fair knee function), Positive Waldron’s test and Patellofemoral Apprehension test, Unilateral patellofemoral pain syndrome |
|
| ExclusionCriteria |
| Details |
History of Recent knee surgery and Arthritis, History of Recent Dislocation and Subluxation of knee, Recent Acute Ligament and Tendon Rupture of knee, Recent Articular Capsule and Meniscus Related Injury of knee, Unresponsive to Conservative Medical Treatment |
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
1.VISUAL ANALOGUE SCALE
2.LYSHOLM KNEE SCORING SCALE
3.HAND HELD DYNAMOMETER |
6 MONTHS |
|
|
Secondary Outcome
|
|
|
Target Sample Size
|
Total Sample Size="30"
Sample Size from India="30"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
10/09/2025 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0"
Months="6"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Patellofemoral pain syndrome (PFPS) is a prevalent musculoskeletal condition characterized by anterior knee pain, particularly during weightbearing activities. Rehabilitation strategies often incorporate both open kinetic chain (OKC) and closed kinetic chain (CKC) exercises to address pain, improve function, and enhance muscle strength. However, the comparative effectiveness of these two approaches remains underexplored in patients with unilateral PFPS. Study aims to compare the effects of CKC exercises versus OKC exercises on pain reduction, functional activity, and quadriceps muscle strength in individuals with unilateral PFPS. A randomized controlled trial was conducted with 30 participants diagnosed with unilateral PFPS. Participants were randomly assigned to either the CKC exercise group or the OKC exercise group for a 6-month intervention program. Outcome measures included pain assessment using the (VAS), functional activity evaluated with the Lysholm knee scoring scale, and strength measured with a handheld dynamometer. Assessments were performed at baseline and post-intervention
|