| CTRI Number |
CTRI/2026/01/101424 [Registered on: 19/01/2026] Trial Registered Prospectively |
| Last Modified On: |
16/01/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Physiotherapy (Not Including YOGA) |
| Study Design |
Randomized, Parallel Group, Active Controlled Trial |
|
Public Title of Study
|
The impact of Neuromuscular training on Knee health in young adults with Patellofemoral Pain Syndrome. |
|
Scientific Title of Study
|
Effectiveness of Neuromuscular Control training exercises on pain, proprioception, dynamic balance and functional status in young adults with unilateral chronic Patellofemoral Pain Syndrome A Randomized Controlled Trail |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
Other |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Adajania Punita Kishor |
| Designation |
Assistant Professor |
| Affiliation |
SPB Physiotherapy college |
| Address |
SPB Physiotherapy College
Room No.4
Musculoskeletal and sports Department
Ugat Bhesan Road
Morabhagal
Surat SPB Physiotherapy College
Room No.4
Musculoskeletal and sports Department
Ugat Bhesan Road
Morabhagal
Surat Surat GUJARAT 395005 India |
| Phone |
8980611286 |
| Fax |
|
| Email |
punita.adajania@gmail.com |
|
Details of Contact Person Scientific Query
|
| Name |
Dr Anjan Desai |
| Designation |
Professor and Incharge principle |
| Affiliation |
SPB Physiotherapy college |
| Address |
SPB Physiotherapy College
1st Floor
Ugat Bhesan Road
Morabhagal
Surat SPB Physiotherapy College
1st Floor
Ugat Bhesan Road
Morabhagal
Surat Surat GUJARAT 395005 India |
| Phone |
9428906995 |
| Fax |
|
| Email |
anjandesai@gmail.com |
|
Details of Contact Person Public Query
|
| Name |
Dr Anjan Desai |
| Designation |
Professor and Incharge principal |
| Affiliation |
SPB Physiotherapy college |
| Address |
SPB Physiotherapy College
1st floor
Ugat Bhesan Road
Morabhagal
Surat SPB Physiotherapy College
1stfloor
Ugat Bhesan Road
Morabhagal Surat GUJARAT 395005 India |
| Phone |
9428906995 |
| Fax |
|
| Email |
anjandesai@gmail.com |
|
|
Source of Monetary or Material Support
|
|
|
Primary Sponsor
|
| Name |
Adajania Punita Kishor |
| Address |
SPB Physiotherapy College (musculoskeletal and sports department)Ugat Bhesan Road Morabhagal Surat |
| Type of Sponsor |
Other [self] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Punita Adajania |
SPB Physiotherapy College |
OPD No. 4
musculoskeletal and sports department
Ugat Bhesan road
morabhagal
Surat Surat GUJARAT |
8980611286
punita.adajania@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional EthicsCommittee |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: M238||Other internal derangements of knee, (2) ICD-10 Condition: M958||Other specified acquired deformities of musculoskeletal system, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Comparator Agent |
Conventional exercises |
Control group will be administered only conventional exercises for 4 weeks.(6 days/week). |
| Intervention |
Conventional exercises and Neuromuscular Control Training exercises |
Experimental group will be administered Conventional exercises and Neuromuscular Control Training exercises on Sensbalance MiniBoard for 4 weeks.(6 days/week). |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
30.00 Year(s) |
| Gender |
Both |
| Details |
Age 18 to 30 years
Both the gender will be included, i.e. male and female.
Duration of knee pain more than 3 months
NPRS 4 – 7 (Moderate)
Patient diagnosed using Physical and functional Diagnosis using diagnostic criteria for PFPS: Presence of retropatellar pain elicited by one of the following symptom provocation tests:
resisted terminal knee extension, stair descent, or unilateral partial squat.
|
|
| ExclusionCriteria |
| Details |
Undergone knee surgery
History of joint replacement–Hip or knee
Intraarticular steroid injections at knee joint
Systemic arthritic condition
Patients with any neurological, respiratory, cardiac or other conditions that would significantly compromise their ability to complete the intervention.
Individuals with malignancy, infectious disease, rheumatological disease, systemic disease.
Any visual disturbance that interferes with visual feedback.
History of Ligament and meniscal injury.
History of lower limb fractures.
History of Post surgical condition of lower limb.
Any visual disturbance that interferes with visual feedback.
Osteoarthritis of knee.
History of Patellar subluxation.
Diagnosed Osteoporosis.
Signs of nerve root compression.
|
|
|
Method of Generating Random Sequence
|
Coin toss, Lottery, toss of dice, shuffling cards etc |
|
Method of Concealment
|
Sequentially numbered, sealed, opaque envelopes |
|
Blinding/Masking
|
Participant Blinded |
|
Primary Outcome
|
| Outcome |
TimePoints |
| Pain, proprioception, dynamic balance and functional status |
Baseline and 4 weeks |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| NIL |
NIL |
|
|
Target Sample Size
|
Total Sample Size="60" Sample Size from India="60"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
02/02/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="4" Months="0" Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Title :EFFECTIVENESS OF NEUROMUSCULAR CONTROL TRAINING EXERCISES ON PAIN, PROPRIOCEPTION, DYNAMIC BALANCE AND FUNCTIONAL STATUS IN YOUNG ADULTS WITH UNILATERAL CHRONIC PATELLOFEMORAL PAIN SYNDROME-A RANDOMIZED CONTROLLED TRIAL Patellofemoral pain syndrome (PFPS) is a common musculoskeletal condition with a high incidence in young active adolescents, as well as in other age groups. The prevalence of PFPS is twice as high in women as in men, and this high prevalence imposes health care and socioeconomic costs on communities. Inflammation, stiffness, giving way, crepitation, and diffuse retro patellar pain during functional activities, such as stair climbing, are prevalent among these patients. PFPS development is probably multifactorial with various functional disorders of the lower extremity. Several risk factors have been proposed as possible parameters involved in pathogenesis of PFPS. These risk factors are classified as intrinsic or extrinsic risk factors. Due to lack of proprioception inputs in patients with PFPS are prone for loss of balance and affect their overall function. Proprioceptive rehabilitation decreases the incidence of injury or improves the results of treatment. Proprioceptive deficiency has been shown to cause abnormal stress accumulation in the surrounding tissue by obstructing the movements and consequently contributes to the occurrence of further problems in the joint. Neuromuscular Control Training Exercises On Sens balance Mini board (Sensa move, Netherlands) The performance of the exercises, administered according to the standardized protocols will be recorded by the researcher. It needs to be explained and the feet positioning on the board is to be identified. Before the first testing takes place, there will be an implementation phase about five minutes, in which the participant explores each task for 30 seconds to get familiar with the equipment and to find out the best feet positioning. Before the patient gets on the balance board, the calibration of the device will be done for each patient in order to make sure that the red spot comes to the middle of the screen and the balance board is completely horizontal. Patients will be asked to take off their shoes and their feet were placed at the specific places of the round balance board indicated by the researcher. They will be allowed to hold the standing bars before the test starts. This will be very important because they could set their initial balance and get a confidence about the device. As the balance board is an unsteady surface, that will be important that the patients rely on the balance device, therefore the initial holding the standing bars will be very important and helpful. The patient will be in formed to release their hands when the test starts and trying not to hold and use the standing bars. Conventional exercises will be given on daily basis (6 days/week) for 4 weeks. It includes semi squat, quadriceps isometric, terminal knee extension in supine position, terminal knee extension in sitting position, Clamshell exercise, Straight leg raise exercise and stretching of IT Band. TENS would be given for pain relief. This protocol will be followed for 4 weeks and progression will be done by adding weights as per patient’s tolerance. Patients diagnosed with unilateral PFPS will be randomly allocated to two groups – Group 1 [Experimental] who will be administered Conventional exercises and Neuromuscular Control Training exercises on Sens balance Mini Board. Group2[Control],who will be administered only conventional exercises. Intervention duration will be of 4 weeks and outcome measures will be measured at the initiation of the study and at the end of 4th week. Intervention will be given on daily basis (6 days/week) for 4 weeks. The patients will be screened on the basis of inclusion and exclusion criteria and their demographic data will be taken by an assessment performa . The researcher will ensure that the patient should not take any medications, is free from any injury, disease or symptoms that could affect the balance abilities and been a risk factor for the performances. Prior to the commencement of the study, detailed procedure of the study will be explained to the patients and assigned informed consent form will be taken from them . Patients will be allocated to any of the two groups by random allocation using SNOSE method. Appropriate physiotherapy interventions will be applied to the patients in both groups and assessment of outcome measures will be done at the initiation and after 4 weeks. In experimental group, patients will receive Neuromuscular control training exercises on Sens balance Mini board in addition to the conventional therapy. |