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CTRI Number  CTRI/2026/01/101424 [Registered on: 19/01/2026] Trial Registered Prospectively
Last Modified On: 16/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   The impact of Neuromuscular training on Knee health in young adults with Patellofemoral Pain Syndrome. 
Scientific Title of Study   Effectiveness of Neuromuscular Control training exercises on pain, proprioception, dynamic balance and functional status in young adults with unilateral chronic Patellofemoral Pain Syndrome A Randomized Controlled Trail 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  Other 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Adajania Punita Kishor 
Designation  Assistant Professor 
Affiliation  SPB Physiotherapy college  
Address  SPB Physiotherapy College Room No.4 Musculoskeletal and sports Department Ugat Bhesan Road Morabhagal Surat
SPB Physiotherapy College Room No.4 Musculoskeletal and sports Department Ugat Bhesan Road Morabhagal Surat
Surat
GUJARAT
395005
India 
Phone  8980611286  
Fax    
Email  punita.adajania@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Anjan Desai 
Designation  Professor and Incharge principle 
Affiliation  SPB Physiotherapy college  
Address  SPB Physiotherapy College 1st Floor Ugat Bhesan Road Morabhagal Surat
SPB Physiotherapy College 1st Floor Ugat Bhesan Road Morabhagal Surat
Surat
GUJARAT
395005
India 
Phone  9428906995  
Fax    
Email  anjandesai@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Anjan Desai 
Designation  Professor and Incharge principal 
Affiliation  SPB Physiotherapy college  
Address  SPB Physiotherapy College 1st floor Ugat Bhesan Road Morabhagal Surat
SPB Physiotherapy College 1stfloor Ugat Bhesan Road Morabhagal
Surat
GUJARAT
395005
India 
Phone  9428906995  
Fax    
Email  anjandesai@gmail.com  
 
Source of Monetary or Material Support  
NIL 
 
Primary Sponsor  
Name  Adajania Punita Kishor 
Address  SPB Physiotherapy College (musculoskeletal and sports department)Ugat Bhesan Road Morabhagal Surat 
Type of Sponsor  Other [self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Punita Adajania  SPB Physiotherapy College  OPD No. 4 musculoskeletal and sports department Ugat Bhesan road morabhagal Surat
Surat
GUJARAT 
8980611286

punita.adajania@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional EthicsCommittee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M238||Other internal derangements of knee, (2) ICD-10 Condition: M958||Other specified acquired deformities of musculoskeletal system,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Conventional exercises  Control group will be administered only conventional exercises for 4 weeks.(6 days/week). 
Intervention  Conventional exercises and Neuromuscular Control Training exercises  Experimental group will be administered Conventional exercises and Neuromuscular Control Training exercises on Sensbalance MiniBoard for 4 weeks.(6 days/week). 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  30.00 Year(s)
Gender  Both 
Details  Age 18 to 30 years
Both the gender will be included, i.e. male and female.
Duration of knee pain more than 3 months
NPRS 4 – 7 (Moderate)
Patient diagnosed using Physical and functional Diagnosis using diagnostic criteria for PFPS: Presence of retropatellar pain elicited by one of the following symptom provocation tests:
resisted terminal knee extension, stair descent, or unilateral partial squat.

 
 
ExclusionCriteria 
Details  Undergone knee surgery
History of joint replacement–Hip or knee
Intraarticular steroid injections at knee joint
Systemic arthritic condition
Patients with any neurological, respiratory, cardiac or other conditions that would significantly compromise their ability to complete the intervention.
Individuals with malignancy, infectious disease, rheumatological disease, systemic disease.
Any visual disturbance that interferes with visual feedback.
History of Ligament and meniscal injury.
History of lower limb fractures.
History of Post surgical condition of lower limb.
Any visual disturbance that interferes with visual feedback.
Osteoarthritis of knee.
History of Patellar subluxation.
Diagnosed Osteoporosis.
Signs of nerve root compression.
 
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Sequentially numbered, sealed, opaque envelopes 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
Pain, proprioception, dynamic balance and functional status  Baseline and 4 weeks 
 
Secondary Outcome  
Outcome  TimePoints 
NIL  NIL 
 
Target Sample Size   Total Sample Size="60"
Sample Size from India="60" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   02/02/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="4"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Title :EFFECTIVENESS OF NEUROMUSCULAR CONTROL TRAINING EXERCISES ON PAIN, PROPRIOCEPTION, DYNAMIC BALANCE AND FUNCTIONAL STATUS IN YOUNG ADULTS WITH UNILATERAL CHRONIC PATELLOFEMORAL PAIN SYNDROME-A RANDOMIZED CONTROLLED TRIAL

Patellofemoral pain syndrome (PFPS) is a common musculoskeletal condition with a high incidence in young active adolescents, as well as in other age groups.
The  prevalence  of  PFPS is twice as high in women as in men, and this high prevalence imposes health care and socioeconomic costs on communities. Inflammation, stiffness, giving way, crepitation, and diffuse retro patellar pain during functional activities, such as stair climbing, are prevalent among these patients.

PFPS development is probably multifactorial with various functional disorders of the lower extremity. Several risk factors have been proposed as possible parameters involved in pathogenesis of PFPS. These risk factors are classified as intrinsic or extrinsic risk factors. Due to lack of proprioception inputs in patients with PFPS are prone for loss of balance and affect their overall function. Proprioceptive rehabilitation decreases the incidence of injury or improves the results of treatment. Proprioceptive deficiency has been shown to cause abnormal stress accumulation in the surrounding tissue by obstructing the movements and consequently contributes to the occurrence of further problems in the joint.

Neuromuscular Control Training Exercises On Sens balance Mini board (Sensa move, Netherlands)  The performance of the exercises, administered according to the standardized protocols will be recorded by the researcher. It needs to be explained and the feet positioning on the board is to be identified. Before the first testing takes place, there will be an implementation phase about five minutes, in which the participant explores each task for 30 seconds to get familiar with the equipment and to find out the best feet positioning. Before the patient gets on the balance board, the calibration of the device will be done for each patient in order to make sure that the red spot comes to the middle of the screen and the balance board is completely horizontal. Patients will be asked to take off their shoes and their feet were placed at the specific places of the round balance board indicated by the researcher. They will be allowed to hold the standing bars before the test starts. This will be very important because they could set their initial balance and get a confidence about the device. As the balance board is an unsteady surface, that will be important that the patients rely on the balance device, therefore the initial holding the standing bars will be very important and helpful. The patient will be in formed to release their hands when the test starts and trying not to hold and use the standing bars.

Conventional exercises will be given on daily basis (6 days/week) for 4 weeks. It includes semi squat, quadriceps isometric, terminal knee extension in supine position, terminal knee extension in sitting position, Clamshell exercise, Straight leg raise exercise and stretching of IT Band. TENS would be given for pain relief. This protocol will be followed for 4 weeks and progression will be done by adding weights as per patient’s tolerance.

Patients diagnosed with unilateral PFPS will be randomly allocated to two groups – Group 1 [Experimental] who will be administered Conventional exercises and Neuromuscular Control Training exercises on Sens balance Mini Board. Group2[Control],who will be administered only conventional exercises. Intervention duration will be of 4 weeks and outcome measures will be measured at the initiation of the study and at the end of 4th week. Intervention will be given on daily basis (6 days/week) for 4 weeks.

The patients will be screened on the basis of inclusion and exclusion criteria and their demographic data will be taken by an assessment performa . The researcher will ensure that the patient should not take any medications, is free from any injury, disease or symptoms that could affect the balance abilities and been a risk factor for the performances. Prior to the commencement of the study, detailed procedure of the study will be explained to the patients  and assigned informed consent form will be taken from them . Patients will be allocated to any of the two groups by random allocation using SNOSE method. Appropriate physiotherapy interventions will be applied to the patients in both groups and assessment of outcome measures will be done at the initiation and after 4 weeks. In experimental group, patients will receive Neuromuscular control training exercises on Sens balance Mini board in addition to the conventional therapy.

 

 

 

 

 

 
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