| CTRI Number |
CTRI/2026/02/103504 [Registered on: 10/02/2026] Trial Registered Prospectively |
| Last Modified On: |
09/02/2026 |
| Post Graduate Thesis |
No |
| Type of Trial |
Interventional |
|
Type of Study
|
Yoga & Naturopathy |
| Study Design |
Randomized, Parallel Group Trial |
|
Public Title of Study
|
Effect of Yoga on Work Related Muscle and Joint Problems in IT Professionals |
|
Scientific Title of Study
|
Effect of Yogic Practices on Biochemical Markers of Work-related Selected Musculoskeletal Disorders among IT Professionals |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Pedasingu Sharmila Devi |
| Designation |
Ph.D. Scholar |
| Affiliation |
Central University of Kerala |
| Address |
Department of the Yoga Studies, Yamuna Block, Central University of Kerala, Tejaswini Hills, Periye (PO), Kasaragod, Kerala - 671325
Kasaragod
KERALA
671325
India |
| Phone |
7310573130 |
| Fax |
|
| Email |
pedasingusharmiladevi.2302207007@cukerala.ac.in |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr.M.Anjaladevi |
| Designation |
Assistant Professor |
| Affiliation |
Central University of Kerala |
| Address |
Department of the Yoga Studies, Yamuna Block, Central University of Kerala, Tejaswini Hills, Periye (PO), Kasaragod, Kerala - 671325
Kasaragod
KERALA
671325
India |
| Phone |
9789253529 |
| Fax |
|
| Email |
anjaladevi.m@cukerala.ac.in |
|
Details of Contact Person
Public Query
|
| Name |
Pedasingu Sharmila Devi |
| Designation |
Ph.D. Scholar |
| Affiliation |
Central University of Kerala |
| Address |
Department of the Yoga Studies, Yamuna Block, Central University of Kerala, Tejaswini Hills, Periye (PO), Kasaragod, Kerala - 671325
Kasaragod
KERALA
671325
India |
| Phone |
7310573130 |
| Fax |
|
| Email |
pedasingusharmiladevi.2302207007@cukerala.ac.in |
|
|
Source of Monetary or Material Support
|
| Cybercity Marina Skies, Green Hills Rd, opp. to IDL Lake Road, Cybercity, Kukatpally, Hyderabad, Telangana 500018 |
|
|
Primary Sponsor
|
| Name |
Central University of Kerala |
| Address |
Central University of Kerala, Tejaswini Hills, Periye, Kasaragod, Kerala -671325 |
| Type of Sponsor |
Research institution |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Pedasingu Sharmila Devi |
Cybercity Marina Skies Residential Community |
Cybercity Marina Skies Residential Community, Yoga Hall, Club house Green Hills Road, Opposite IDL Lake Road
Cybercity, Kukatpally, Hyderabad, Telangana - 500018,
India
Hyderabad
TELANGANA |
7310573130
pedasingusharmiladevi.2302207007@cukerala.ac.in |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional Human Ethics Committee (IHEC), Central University of Kerala |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition:G560||Carpal tunnel syndrome. Ayurveda Condition: NANATMAJAVATAVIKARAH, (2) ICD-10 Condition:M545||Low back pain. Ayurveda Condition: NANATMAJAVATAVIKARAH, (3) ICD-10 Condition:M501||Cervical disc disorder with radiculopathy. Ayurveda Condition: NANATMAJAVATAVIKARAH, |
|
|
Intervention / Comparator Agent
|
| sno | Intervention/Comparator | Type | Drug-Type | Procedure Name | Details | | 1 | Intervention Arm | Procedure | - | NA | (Procedure Reference: (Garfinkel et al., 1984); (Pravalika et al., 2023); (Kim, 2018), Procedure details: All the participants in yoga groups will follow the Yogic Intervention for 60 minutes, 6 days per week. This Yogic Intervention is prepared from the evidence of previous studies(Garfinkel et al., 1984); (Pravalika et al., 2023); (Kim, 2018))
|
|
|
|
Inclusion Criteria
|
| Age From |
30.00 Year(s) |
| Age To |
45.00 Year(s) |
| Gender |
Both |
| Details |
Participants must be between 30 and 45 years of age.
Participants must be currently employed as an information technology professional with a minimum of two years of work experience in the industry.
Participants must have a clinically diagnosed work related musculoskeletal disorder such as Carpal Tunnel Syndrome Cervical Radiculopathy or Lower Back Pain confirmed through physical examination and appropriate diagnostic tests including Tinel sign Phalen test Spurling test and straight leg raise test.
Participants must work at least thirty five hours per week in a predominantly sedentary occupation involving prolonged computer use.
Participants must be willing to participate in a twelve week yogic intervention program and comply with the study protocol.
Participants must provide written informed consent prior to participation in the study. |
|
| ExclusionCriteria |
| Details |
Individuals with severe or advanced musculoskeletal disorders requiring surgical intervention or those who have undergone musculoskeletal surgery within the past one year.
Participants with chronic medical conditions such as cardiovascular diseases or autoimmune disorders that may influence the study outcomes.
Individuals who have practiced yoga or similar physical activity programs such as Pilates or Tai Chi on a regular basis more than twice per week during the previous six months.
Pregnant women or women planning pregnancy during the study period.
Participants with severe psychiatric illness or cognitive impairment that may interfere with adherence to the study protocol.
Individuals who are currently participating in any other clinical trial or therapeutic intervention that could affect the study outcomes. |
|
|
Method of Generating Random Sequence
|
Computer generated randomization |
|
Method of Concealment
|
Sequentially numbered, sealed, opaque envelopes |
|
Blinding/Masking
|
Open Label |
|
Primary Outcome
|
| Outcome |
TimePoints |
| Change in biochemical markers including inflammatory markers IL1 IL6 and TNF alpha oxidative stress markers ROS MDA and SOD and neurotrophic factors NGF BDNF and Neurotrophin three from baseline to post intervention in information technology professionals with work related musculoskeletal disorders such as Carpal Tunnel Syndrome Cervical Radiculopathy and Lower Back Pain following yogic practices compared to a control group. |
Baseline
At twelve weeks post-intervention |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| Change in Tinel’s Sign, Phalen’s Test, Spurling’s Test, and Straight Leg Raise Test results |
baseline (Week 0) and post-intervention (Week 12) |
| Change in Electromyography (EMG) |
baseline (Week 0) and post-intervention (Week 12) |
| hange in functional disability assessed by disease-specific scales (DASH for Carpal Tunnel Syndrome, Neck Disability Index for Cervical Radiculopathy, Oswestry Disability Index for Low Back Pain) |
baseline (Week 0) and post-intervention (Week 12) |
|
|
Target Sample Size
|
Total Sample Size="134"
Sample Size from India="134"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
01/04/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0"
Months="3"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
This randomized controlled trial aims to evaluate the effect of a structured yogic practice program on biochemical and clinical outcomes of selected work-related musculoskeletal disorders among information technology professionals. Eligible participants diagnosed with carpal tunnel syndrome, cervical radiculopathy, or lower back pain will be screened and randomly assigned to experimental and control groups. The experimental group will receive a 12 week yogic practice program while the control group will continue routine lifestyle practices without intervention. The primary outcomes include changes in biochemical markers such as inflammatory markers, oxidative stress markers, and neurotrophic factors. Secondary outcomes include improvements in clinical assessment tests, electromyography, reduced pain, improved musculoskeletal function, and enhanced occupational performance. The study aims to establish yoga as a cost effective safe and non invasive intervention for promoting health and productivity among information technology professionals with work related musculoskeletal disorders. |