Propofol is a rapidly acting and most commonly used intravenous inducing  

agent for general anaesthesia due to its smooth induction and rapid recovery  

properties.The side effects of Propofol include hypotension,apnea,pain on  

injection and myoclonus.Pain on injection is a major problem with incidence  

of 28%-85%.Several methods have been administered over the years to  

reduce the pain associated with IV injection of Propofol.These include non  

drug category, drug category and conjugation of two.The non drug category  

includes injection sites,needle sizes,temperature, venous occlusion, micro  

filtration.The drug category constituted various drugs or drug combination.

• Lignocaine pretreatment is most commonly used to decrease Propofol  

injection pain. Intravenous Lignocaine hydrochloride a cation solution  

when exposed to lipids in Propofol , liberates protons and decreases  

the pH of the solution,the lower pH decreases the anions in  

Propofol,hence more amount of Propofol enters into the lipid phase  

and will cause reduced pain on injection. 

• The study is aimed at comparing effect of two different doses of IV  

Lignocaine pretreatment for prevention of pain during Propofol  

induction and to find the effect of lower dose of Lignocaine with  

60seconds venous occlusion.