Dyslipidemia, characterized by elevated cholesterol, triglycerides, LDL or reduced HDL, is a major risk factor for atherosclerosis. In Ayurveda, it is correlated with Shonita Abhishyanda, a condition arising from Santarpana Nidana such as heavy diet, sedentary lifestyle and incompatible food (Viruddhara) leading to excessive Kapha and Meda in Rasa-Raktavaha Srotas as mentioned in Charaka Samhita, leading to Medoroga. Being Santarpanajanya Vyadhi it requires Apatarpana chikitsa along with srotoshodhana. Basti therapy is considered Ardha Chikitsa  has Lekhana, Chedana and Apatarpana properties that helps in reducing pathological meda and correcting agni. Hence Vachadi Gana and Haridradi Gana are indicated in Medoj and Kaphaja Vikara (i.e. Dyslipidemia) in Shodhanadi Gana adhyaya of Ashtanga Hridyam. In the present trial 30 patients will be enrolled who are diagnosed with Dyslipidemia fulfilling the inclusion and exclusion criteria and dividing them into two groups of 15 each. Group A will receive Vachadi Gana Kala Basti and Group B will receive Haridradi Gana Kala Basti each with a single sitting of 16 days. Clinical outcomes and biochemical parameters ( Lipid Profile including Total Cholesterol, Triglycerides, LDL and HLD) will be assessed to evaluate the efficacy of two interventions. This study aims to establish effective Ayurvedic Treatment approaches for the management of Dyslipidemia under the topic "Comparative Clinical Evaluation of Vachadi Gana and Haridradi Gana Kala Basti in Dyslipidemia."