| CTRI Number |
CTRI/2025/11/097467 [Registered on: 14/11/2025] Trial Registered Prospectively |
| Last Modified On: |
13/11/2025 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Observational |
|
Type of Study
|
Cross Sectional Study |
| Study Design |
Other |
|
Public Title of Study
|
ROLE OF MAGNETIC RESONANCE IMAGING IN
DIAGNOSING BRAIN INFECTIONS
|
|
Scientific Title of Study
|
ROLE OF MAGNETIC RESONANCE IMAGING IN
EVALUATION OF INTRA CRANIAL INFECTIONS |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Utkarsh Kaura |
| Designation |
Post Graduate Student |
| Affiliation |
Jawaharlal Nehru Medical College, Sawangi(Meghe), Wardha, Maharastra |
| Address |
Jawaharlal Nehru Medical College, Sawangi(Meghe), Wardha, Maharastra
Wardha
MAHARASHTRA
442107
India |
| Phone |
9713429500 |
| Fax |
|
| Email |
utkarsh.kaura@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr Ramesh Chaple |
| Designation |
Professor |
| Affiliation |
Jawaharlal Nehru Medical College, Sawangi(Meghe), Wardha, Maharastra |
| Address |
Jawaharlal Nehru Medical College, Sawangi(Meghe), Wardha, Maharastra
Wardha
MAHARASHTRA
442107
India |
| Phone |
7875920055 |
| Fax |
|
| Email |
dr.rrchaple@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Dr Ramesh Chaple |
| Designation |
Professor |
| Affiliation |
Jawaharlal Nehru Medical College, Sawangi(Meghe), Wardha, Maharastra |
| Address |
Jawaharlal Nehru Medical College, Sawangi(Meghe), Wardha, Maharastra
Wardha
MAHARASHTRA
442107
India |
| Phone |
7875920055 |
| Fax |
|
| Email |
dr.rrchaple@gmail.com |
|
|
Source of Monetary or Material Support
|
| Jawaharlal Nehru Medical College,Sawangi(Meghe),Wardha,442001,Maharashtra |
|
|
Primary Sponsor
|
| Name |
Jawaharlal Nehru Medical College,Sawangi(Meghe),Wardha,442001,Maharashtra |
| Address |
Jawaharlal Nehru Medical College,Sawangi(Meghe),Wardha,442001,Maharashtra |
| Type of Sponsor |
Other [Self] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Utkarsh Kaura |
Acharya vinobha bhave rural hospital |
Radiodiagnosis department, Block D, Room number 004
Wardha
MAHARASHTRA |
9713429500
utkarsh.kaura@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional Ethics Committee, Datta Meghe Institute of Higher Education and Research |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: B||Imaging, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Nil |
Nil |
| Intervention |
Nil |
Nil |
|
|
Inclusion Criteria
|
| Age From |
0.00 Day(s) |
| Age To |
90.00 Year(s) |
| Gender |
Both |
| Details |
Patients of all age groups with clinical suspicion of intracranial infection.
Willingness to undergo MRI examination.
|
|
| ExclusionCriteria |
| Details |
Patients who do not give consent.
Contraindications to MRI or gadolinium-based contrast agents
Patients suffering from claustrophobia.
|
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
MRI was undoubtedly an indispensable tool to
evaluate patients presenting with intracranial
infections. Most of the cases were pathognomonic
in imaging appearance; while some required
clinico-laboratory correlation. Careful evaluation
of MR behaviour of infectious lesions helped in
identifying not only the precise location and
extent of the lesion, but also in proposing a
specific etiology in many such patients.
|
8 weeks
|
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| NIL |
NIL |
|
|
Target Sample Size
|
Total Sample Size="44"
Sample Size from India="44"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
15/12/2025 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1"
Months="6"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
This prospective cross-sectional study aims to assess the role of MRI in the evaluation of intracranial infections, which remain a major health concern in India due to their high prevalence, non-specific presentations, and frequent diagnostic delays. A total of 44 patients with clinical suspicion of intracranial infections will undergo MRI using both conventional sequences (T1, T2, FLAIR) and advanced techniques such as diffusion-weighted imaging (DWI), susceptibility-weighted imaging (SWI), and post-contrast studies to evaluate parenchymal, meningeal, and vascular involvement. The study objectives are to describe MRI characteristics of various infections, document clinical presentations, identify imaging predictors of poor prognosis, and correlate radiological findings with CSF analysis. By integrating clinical and imaging data, this study seeks to highlight MRI as a critical non-invasive tool for early diagnosis, prognostication, and treatment planning in intracranial infections, particularly in resource-limited settings. |