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CTRI Number  CTRI/2025/12/098647 [Registered on: 08/12/2025] Trial Registered Prospectively
Last Modified On: 09/12/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Single Arm Study 
Public Title of Study   Effect of buteyko breathing on stress and sleep quality in younger adults with migraine 
Scientific Title of Study   Effect Of Buteyko Breathing Technique as an adjuvant to standard Medical Treatment on Perceived Stress,Quality of Life and Sleep Quality in Younger Adults with Migraine Disability - A Quasi Experimental Study 
Trial Acronym  nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Riddhi Jain 
Designation  intern 
Affiliation  PES Modern college of physiotherapy shivajinagar pune-411005 
Address  Department of Cardiovascular & Respiratory Physiotherapy, PES Modern College of Physiotherapy OPD, PES Modern College, Shivajinagar,Pune-05
PES Modern College of Physiotherapy OPD, PES Modern College, Shivajinagar,Pune-05
Pune
MAHARASHTRA
411005
India 
Phone  8856912571  
Fax    
Email  riddhideepakjain@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Shruti Mankar 
Designation  Assistant Professor 
Affiliation  Assistant Professor PES Modern college of physiotherapy shivajinagar pune-411005 
Address  PES Modern College of Physiotherapy Shivajinagar Pune 05

Pune
MAHARASHTRA
411005
India 
Phone  7276020635  
Fax    
Email  mankarshrutee@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Riddhi Jain 
Designation  intern 
Affiliation  PES Modern college of physiotherapy shivajinagar pune-411005 
Address  Department of Cardiovascular & Respiratory Physiotherapy, PES Modern College of Physiotherapy, Pune -05

Pune
MAHARASHTRA
411005
India 
Phone  8856912571  
Fax    
Email  riddhideepakjain@gmail.com  
 
Source of Monetary or Material Support
Modification(s)  
PES Modern college of Physiotherapy OPD, PES Modern college of Physiotherapy, Pune-05 
 
Primary Sponsor  
Name  NA 
Address  NA 
Type of Sponsor  Other [nil] 
 
Details of Secondary Sponsor  
Name  Address 
nil  nil 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Riddhi jain  PES Modern college of physiotherapy  Department of Cardiovascular & Respiratory Physiotherapy Physiotherapy OPD Shivajinagar Pune -05,Maharashtra India.
Pune
MAHARASHTRA 
08856912571

riddhideepakjain@gmail.com 
 
Details of Ethics Committee
Modification(s)  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Ethics Committee PES Modern College of Physiotherapy  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: G439||Migraine, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Buteyko breathing technique  buteyko breathing technique are breath retraining exercises which consist of nasal breathing low volume breathing and control pause buteyko breathing has been used in hypertension asthama and stress Duration of exercise for 3 times per week for 4 weeks ,session duration of 20-25 minutes 
Comparator Agent  NA  NA 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  25.00 Year(s)
Gender  Both 
Details  Age group 18-25 years
Diagnosed with migraine by department of neuro medicine since 6 months and more
Patients on medicine both symptomatic and prophylactic
Patients with mild to moderate disability scores ranging from 6 to 20 on MIDAS
Patients who score moderate to high i.e scores ranging from 15 to 40 on PSS-10
Patients with PSQI score more than 5
Patient willing to be part of this study
Patient willing to practice exercise at home
 
 
ExclusionCriteria 
Details  Patient with any neurological condition which hinder communication with patient
Patient with active respiratory infection
Patient with any cardiovascular disorder
Patient with recent abdominal surgery or organ transplant
Pregnant females

 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Percieved stress scale
Migraine specific quality of life
Pittsburg sleep quality index 
Pre- intervention
at the end of 4 weeks 
 
Secondary Outcome  
Outcome  TimePoints 
The Migraine Disability assessment test  pre-intervention
at the end of 4 weeks 
 
Target Sample Size   Total Sample Size="38"
Sample Size from India="38" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   17/12/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="5"
Days="30" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
This study aims to evaluate the effectiveness of the Buteyko Breathing Technique on perceived stress, sleep quality, and quality of life in young adults with migraine related disability. Migraine is influenced by stress and disturbed sleep, and these factors can worsen migraine frequency and symptom severity. The Buteyko Breathing Technique uses slow nasal breathing and control pause training to reduce sympathetic overactivation and stabilize carbon dioxide levels. These physiological changes may help decrease chronic hyperventilation, promote relaxation, and improve autonomic balance.

Participants aged 18 to 25 years who have mild to moderate migraine disability and score in the moderate or high range on the Perceived Stress Scale and poor sleep quality that is score more than 5 on Pittsburgh sleep quality index will be included. All participants will undergo baseline assessment using the Perceived Stress Scale, Pittsburgh Sleep Quality Index, and the Migraine Specific Quality of Life Questionnaire. The intervention will consist of Buteyko Breathing Technique sessions for four weeks for 3 days in a week twice a day for twenty minutes

After the intervention, the same outcome measures will be repeated to compare pre and post intervention changes. The study will help determine whether Buteyko Breathing Technique can be used as a safe and cost effective method to reduce stress, improve sleep quality, and improve migraine related quality of life in young adults.
 
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