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CTRI Number  CTRI/2025/08/093348 [Registered on: 20/08/2025] Trial Registered Prospectively
Last Modified On: 20/08/2025
Post Graduate Thesis  No 
Type of Trial  Observational 
Type of Study   Cohort Study 
Study Design  Other 
Public Title of Study   Intensive Care Unit admission in Young Adults (18- 40 years) 
Scientific Title of Study   Clinical profile and outcomes of young adults (18- 40 years) admitted to the ICU: A Prospective Cohort study 
Trial Acronym  YOUNG ADULTS- ICU 
Secondary IDs if Any  
Secondary ID  Identifier 
EC/NEW/INST/2023/TN/0293  Other 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  S Jessica Janet  
Designation  Critical Care Technologist  
Affiliation  Sri Ramachandra Institute of Higher Education and Research  
Address  No. 29 (4) East Tank Street, Nandambakkam, Chennai

Thiruvallur
TAMIL NADU
600089
India 
Phone  7550035785  
Fax    
Email  jessijeni19@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  S Jessica Janet  
Designation  Critical Care Technologist  
Affiliation  Sri Ramachandra Institute of Higher Education and Research  
Address  No. 29 (4) East Tank Street, Nandambakkam, Chennai

Thiruvallur
TAMIL NADU
600089
India 
Phone  7550035785  
Fax    
Email  jessijeni19@gmail.com  
 
Details of Contact Person
Public Query
 
Name  S Jessica Janet  
Designation  Critical Care Technologist  
Affiliation  Sri Ramachandra Institute of Higher Education and Research  
Address  No. 29 (4) East Tank Street, Nandambakkam, Chennai

Thiruvallur
TAMIL NADU
600089
India 
Phone  7550035785  
Fax    
Email  jessijeni19@gmail.com  
 
Source of Monetary or Material Support  
Nil 
 
Primary Sponsor  
Name  Sri Ramachandra Institute of Higher Education and Research 
Address  Department of Critical Care Medicine, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai- 600116 
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
NIL   
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr S Velmurugan  Sriramachandra Institute of Higher Education and Research   Department of Critical Care Medicine, SRIHER(DU), Porur, Chennai-600116
Thiruvallur
TAMIL NADU 
9968859560

dr.velsri86@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
INSTITUTIONAL ETHICAL COMITTEE  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: T814||Infection following a procedure,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  40.00 Year(s)
Gender  Both 
Details  Patients aged 18 to 40 years.
Admitted to ICU for greater than or equal to 24 hours during the study period. 
 
ExclusionCriteria 
Details  ICU re- admissions during the same hospitalization (only the first admission will be considered). Patients or relatives who decline to provide informed consent (if required by IEC). 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
ICU mortality rate among young adults   One year 
 
Secondary Outcome  
Outcome  TimePoints 
Length of ICU stay
Need of organ support
Complications rates
Predictors of poor outcomes
Hospital discharge status  
One year 
 
Target Sample Size   Total Sample Size="250"
Sample Size from India="250" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   31/08/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Young adults, typically aged 18 to 40 years, are generally considered to be in good health. However, this age group is increasingly encountering severe illnesses and injuries that require admission to intensive care units (ICUs). In India, trauma, severe infections (including sepsis), acute poisoning, and exacerbations of chronic diseases are among the leading causes of ICU admission in this population. Although younger patients often have fewer comorbidities and better physiological reserves compared to older patients, they are not
immune to poor outcomes, including death and long-term disability.Despite the growing need to understand critical illness in young adults, most studies in the critical care literature focus predominantly on the elderly. Many ICU outcome studies aggregate adult data without stratifying by age, potentially obscuring age-specific trends and risk factors. Furthermore, data from high-income countries may not be directly applicable to the Indian context, where the disease burden, healthcare-seeking behaviour, and resource availability differ significantly. Given these gaps, there is a need for well-designed, prospective studies that focus specifically on young adults in the ICU. This study aims to prospectively evaluate the clinical characteristics, treatment interventions, and outcomes of patients aged 18–40 years admitted to the ICU over a one-year period. Findings from this study will provide valuable insights into risk stratification, treatment planning, and prognosis in this under-researched group.
 
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