| CTRI Number |
CTRI/2026/01/102630 [Registered on: 30/01/2026] Trial Registered Prospectively |
| Last Modified On: |
08/01/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Ayurveda |
| Study Design |
Randomized, Parallel Group Trial |
|
Public Title of Study
|
Traditional Ayurvedic Pressure-Point Therapy for Early-Stage High Blood Pressure |
|
Scientific Title of Study
|
A Study on Kshipra Marma and Tala Hridaya Marma with its Therapeutic application on Stage 1 Hypertension |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr. Priyanka Gururani |
| Designation |
M.D. Scholar |
| Affiliation |
Faculty Of Ayurveda, Institute Of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005 |
| Address |
Department Of Rachana Sharira, Faculty Of Ayurveda, Institute Of Medical Sciences, Banaras Hindu University, Varanasi , U.P.
Varanasi
UTTAR PRADESH
221005
India |
| Phone |
8126245730 |
| Fax |
|
| Email |
priyankagururani000@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
H.H. Awasthi |
| Designation |
Senior Professor and HOD |
| Affiliation |
Faculty Of Ayurveda, Institute Of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005 |
| Address |
Department Of Rachana Sharira, Faculty Of Ayurveda, Institute Of Medical Sciences, Banaras Hindu University, Varanasi , U.P.
Varanasi
UTTAR PRADESH
221005
India |
| Phone |
9415813194 |
| Fax |
|
| Email |
hhawasthi10@yahoo.in |
|
Details of Contact Person
Public Query
|
| Name |
H.H. Awasthi |
| Designation |
Senior Professor and HOD |
| Affiliation |
Faculty Of Ayurveda, Institute Of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005 |
| Address |
Department Of Rachana Sharira, Faculty Of Ayurveda, Institute Of Medical Sciences, Banaras Hindu University, Varanasi , U.P.
Varanasi
UTTAR PRADESH
221005
India |
| Phone |
9415813194 |
| Fax |
|
| Email |
hhawasthi10@yahoo.in |
|
|
Source of Monetary or Material Support
|
| Department of Rachana Sharira, FoA, IMS, BHU, Varanasi, Uttar Pradesh 221005 |
| OPD Room no. 103
Department Of Cardiology, IMS, BHU, Varanasi, Uttar Pradesh 221005 |
|
|
Primary Sponsor
|
| Name |
Dr Priyanka Gururani |
| Address |
Department Of Rachana Sharira, Faculty Of Ayurveda, Institute Of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005 |
| Type of Sponsor |
Research institution and hospital |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Priyanka Gururani |
SSH BHU |
Department of cardiology, SSH, BHU, Varanasi, UP
Varanasi
UTTAR PRADESH |
8126245730
priyankagururani000@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional Ethical Committee of Banaras Hindu University |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition:I10||Essential (primary) hypertension. Ayurveda Condition: HRUDROGAH, |
|
|
Intervention / Comparator Agent
|
| sno | Intervention/Comparator | Type | Drug-Type | Procedure Name | Details | | 1 | Comparator Arm (Non Ayurveda) | | - | Group A | Control (Standard drug - as per ESH guidelines). | | 2 | Intervention Arm | Procedure | - | marmacikitsA, मर्मचिकित्सा | (Procedure Reference: Sushruta Samhita, Procedure details: Stimulation of Kshipra Marma & Tala Hridaya Marma of upper limb along with standard drug of anti hypertension)
|
|
|
|
Inclusion Criteria
|
| Age From |
35.00 Year(s) |
| Age To |
60.00 Year(s) |
| Gender |
Both |
| Details |
1. Willing to give consent to participate in the study.
2. Patient in age group between 35-60 years of either sex irrespective of religion, socio economic status and occupation.
3. Patients having Grade 1 Hypertension (SBP= 140-159 mmHg & DBP= 90-99 mmHg) |
|
| ExclusionCriteria |
| Details |
1. Patients with Diabetes Mellitus, thyroid disorders.
2. Patients on steroid medicines.
3. Subjects who are pregnant and lactating.
4. Patients with habits of smoking and alcoholism.
5. Subjects who are with chronic illness except metabolic syndromes.
6. Patients with critical illness like cancer, HIV etc. or hearing impairment.
7. Subjects who are taking any kind of sedatives or psychological treatments.
8. Subjects who are having other renal, hepatic, cardiovascular or respiratory
disorders (such as asthma, bronchitis, or excessive mucus).
9. Patients having Secondary Hypertension.
10. Patients with evidence of Hypertension target organ damage. |
|
|
Method of Generating Random Sequence
|
Computer generated randomization |
|
Method of Concealment
|
An Open list of random numbers |
|
Blinding/Masking
|
Open Label |
|
Primary Outcome
|
| Outcome |
TimePoints |
| Changes in Systolic and Diastolic Blood Pressure |
3 months with follow-up at 1 month interval |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
BMI
RFT
LFT
Lipid Profile
CBC |
3 months with follow-up at 1 month interval |
|
|
Target Sample Size
|
Total Sample Size="140"
Sample Size from India="140"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
Phase 2/ Phase 3 |
|
Date of First Enrollment (India)
|
20/02/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1"
Months="6"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
140 cases of Stage 1 Hypertension will be included in this study which will be randomly divided into 2 groups of 70 patients in each group. First group will be prescribed by standard drugs of anti hypertension as per ESH guidelines. Second group will be prescribed standard drug of Anti hypertension as per ESH guidelines along with stimulation of Kshipra Marma and Tala Hridayay Marma. |