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CTRI Number  CTRI/2026/01/100210 [Registered on: 02/01/2026] Trial Registered Prospectively
Last Modified On: 02/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   See the effect of Trikantakadi kwath and Trunpanchmul kwath in management of pittaj mutrakruchha(Urinary tract infection). 
Scientific Title of Study   A Randomised Controlled Clinical Study to evaluate the efficacy of Trikantakadi Kwath in the management of Pittaj Mutrakruchha w.s.r.to Urinary tract infection. 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Nirali Ganesh Nimodiya  
Designation  MD kayachikitsa scholar 
Affiliation  Dr VJD Gramin Ayurved Mahavidyalaya patur akola 
Address  OPD No.3 , Department of Kayachikitsa, Dr VJD Gramin Ayurved Mahavidyalaya near Renuka Mata Mandir Patur Akola Maharashtra,India

Akola
MAHARASHTRA
444501
India 
Phone  7972866880  
Fax    
Email  nirali2601200@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Jayshree katole 
Designation  Professor and Head of the department, kayachikitsa  
Affiliation  Dr VJD Gramin ayurved mahavidyalaya  
Address  OPD NO 3 Department of Kayachikitsa, Dr VJD Gramin Ayurved Mahavidyalaya, near Renuka mata mandir, Patur, Tal-Patur, Dist-Akola Pin-444501 MAHARASHTRA INDIA

Akola
MAHARASHTRA
444501
India 
Phone  9423847608  
Fax    
Email  drjrkatole@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Jayshree katole  
Designation  Professor and Head of the department, kayachikitsa  
Affiliation  Dr VJD Gramin ayurved mahavidyalya  
Address  OPD NO 3 Department of Kayachikitsa, Dr VJD Gramin Ayurved Mahavidyalaya, near Renuka mata mandir, Patur, Tal-Patur, Dist-Akola Pin-444501 MAHARASHTRA INDIA

Akola
MAHARASHTRA
444501
India 
Phone  942387608  
Fax    
Email  drjrkatole@gmail.com  
 
Source of Monetary or Material Support  
Dr.VJD Gramin Ayurved Mahavidyalaya, near Renuka mata mandir, Patur, Tal-Patur, Dist-Akola, Maharashtra, India Pin-444501 
 
Primary Sponsor  
Name  Dr .VJD Gramin Ayurved Mahavidyalaya,patur  
Address  Dr.VJD Gramin Ayurved Mahavidyalaya, near Renuka mata mandir, Patur, Tal-Patur, Dist-Akola, Maharashtra, India Pin-444501 
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Nirali Ganesh Nimodiya   Dr VJD Gramin Ayurved Mahavidyalaya   OPD No. 3 ,Department of Kayachikitsa Dr VJD Gramin Ayurveda Mahavidyalaya, near Renuka Mata mandir, Patur, Tal Patur,Dist Akola
Akola
MAHARASHTRA 
7972866880

nirali2601200@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethics committee, Dr VJD Gramin ayurved mahavidyalaya patur  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:N390||Urinary tract infection, site notspecified. Ayurveda Condition: PITTAJAMUTRAKRUCCRAM,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmDrugClassical(1) Medicine Name: Trikantakadi kwath, Reference: Bhaisajya ratnawali , Route: Oral, Dosage Form: Kwatha/ Kashaya, Dose: 30(ml), Frequency: bd, Bhaishajya Kal: Adhobhakta, Duration: 15 Days, anupAna/sahapAna: Yes(details: koshnajal ), Additional Information: -
2Comparator ArmDrugClassical(1) Medicine Name: Trunpanchamul kwath , Reference: Bhaisajya Ratnawali , Route: Oral, Dosage Form: Kwatha/ Kashaya, Dose: 30(ml), Frequency: bd, Bhaishajya Kal: Adhobhakta, Duration: 15 Days, anupAna/sahapAna: Yes(details: koshnajal), Additional Information: -
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  1. Patients willing for clinical trial.

2. Patient having the sign and symptom of Pittaj mutrakruccha.

3. The patients of age group 18 to 60 years will be selected.

4. The patients will be selected irrespective of sex & religion. 
 
ExclusionCriteria 
Details  1. Patients not willing for clinical trial.

2. Age less than 18 years and more than 60 years.

3. Severe traumatic cases.

4. Any severe deformity..

5. Pregnant woman, lactating mothers.

6. Any other major illness like HIV, AIDS, TB, HTN, DM and any malignancy.

7. Pateint presenting symptoms due to obstructed pathology like BPH, Renal calculi, vesical calculus cystitis,intersitial cystitis.phimosis.paraphimosis and pelvic inflammatory diseases.

8. Chronicity above 1 year. 
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   An Open list of random numbers 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
1.peet mutrata 2.sarakta mutrata 3.saruja mutrata 4.sadaha Mutrata 5.kruchra mutrata 6.Muhurmuhu mutrata symptoms will be decreased   After 3 days ,8 days and 15 days from starting of treatment  
 
Secondary Outcome  
Outcome  TimePoints 
Decreased symptoms completely  18 months 
 
Target Sample Size   Total Sample Size="80"
Sample Size from India="80" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   15/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="1" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   The word "Ayurveda" in which Ayu means Life and Veda means Knowledge. Therefore Ayurveda means Knowledge of Life. 
Means to maintain the health of healthy one and cure the disease of Diseased one. Hence Ayurveda is sometimes also called as the preventive Science. Thus both prophylaxis and cure are dealt in this science. Everything Which is necessary for the good health has been explained in ayurveda.

Among Trimala, Mutra is responsible for bastipoorana and kleda vahanam. When. this physiology i hampered it leads to Mutravaha strotoas Dushti Vikaras. When person indulges in Nidana sevana like intake of Ati Ruksha, Ushna, Tikshana Ahara, Mutravegadharana, Ati vyavaya leads to diseases of Mutravahasrotodushti vikars. In today’s era the above nidanas are commonly observed due to working pattern or busy schedule or lifestyle of person and indulging in such type of etiology causes vitiation of all three doshas which accumulates in urinary system and does the vitiation of mutra and causes pittaja mutrakrichhra.

Mutrakruchha is a broad term, which covers the conditions Medical Science as Urinary Tract Infection (UTI). The Pratyatma lakshana of Mutrakruchha is Dukhena Mutra pravutti", means discomfort during Micturition. In pittaj Mutrakruchha the vitated pitta dosha along with vata(Mainly Aapana vayu)onreaching basti affects the mutravaha strotas. Urinary tract infections such

as abnormal colour of urine can be compared with Sarakta/Sapeeta Mutrata, burning sensation while micturation can be compared with Sadaha Mutrapravrutti and pain while micturation can be compared with Krucchra Mutrapravrutti, Frequency and urgency can be compared with Muhurmuhu Mutrapravrutti and suprapubic can be compared with saruja/kruchra mutrata.

Urinary tract infections are second in frequency after upper respira infections. Escheria coli is the most common uropathogen identifis studies Medical Science as Urinary Tract Infection (UTI).
Most of are the population from rural area exposed to sunrays, having improper intake of water and Food & which leads to dehydration condition and acidic urine leading to urinary tract infection.

In Urban areas. People have to travel far away for work, daily busy Routine, less water intake, fond of Junk food, Fast Food, holding of Natural urge like urination for long period and use of public toilets frequently and unhygienic practices all this leads to urinary tract infection



Urinary Tract infections are second in frequency after respiratory tract infections, Incidence and degree of morbidity and mortality from infections are greater with those in the urinary tract than with those of the upper respiratory tract. Bacteria are by far the most common invading organisms but fungi, yeasts and viruses also produce urinary tract infections. Thus, urinary tract infection is potentially a serious condition and failure to realize that this may lead to development of serious chronic pyelonephritis and chronic renal failure. With the introduction of effective antibiotics problem has been solved to some extent but the use of, antibiotics have limitations like side effects, chances of reinfection and. relapse even after long-term therapy. Simultaneously increasing incidence of resistance and high cost of therapy are common problems.

Ayurveda offers alternative therapies like Trikantakadi kwath, and Trunpanchmuladi kwath which are believed to have properties such as Pittashamaka (Pitta pacifying) Mutral and anti-microbial effects, making them potential treatments for pittaj Mutrakruchha.
 
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