| CTRI Number |
CTRI/2026/02/104668 [Registered on: 24/02/2026] Trial Registered Prospectively |
| Last Modified On: |
24/02/2026 |
| Post Graduate Thesis |
No |
| Type of Trial |
Interventional |
|
Type of Study
|
Yoga & Naturopathy |
| Study Design |
Other |
|
Public Title of Study
|
Gritha neti and jala neti for respiratory microbiome |
|
Scientific Title of Study
|
Impact of gritha neti versus jala neti on respiratory microbiome among drivers - a randomised comparative study. |
| Trial Acronym |
Nil |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Naveen BR |
| Designation |
UG Scholar |
| Affiliation |
Alvas college of naturopathy and yogic sciences |
| Address |
Department of Yoga
Room no 10 Alvas college of naturopathy and yogic sciences Mijar Moodabidri
Shobavana campus, Mijar, Moodabidri, 574227
Dakshina Kannada
KARNATAKA
574227
India |
| Phone |
9880519174 |
| Fax |
|
| Email |
naveenbr1493@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr Archana K |
| Designation |
Professor |
| Affiliation |
Alvas college of naturopathy and yogic sciences |
| Address |
Yoga department
Shobavana campus, Mijar, Moodabidri, 574227
Dakshina Kannada
KARNATAKA
574227
India |
| Phone |
9448152915 |
| Fax |
|
| Email |
dr.archanabnys@yahoo.com |
|
Details of Contact Person
Public Query
|
| Name |
Dr Deeksha Shenoy |
| Designation |
Assistant professor |
| Affiliation |
Alvas college of naturopathy and yogic sciences |
| Address |
Research department
Shobavana campus Mijar Moodabidri 574227
Dakshina Kannada
KARNATAKA
574227
India |
| Phone |
9535574807 |
| Fax |
|
| Email |
deekshashenoyg77@gmail.com |
|
|
Source of Monetary or Material Support
|
| Alvas Anandamaya Arogyadhama Mijar Moodabidri |
|
|
Primary Sponsor
|
| Name |
Rajiv Gandhi University of Health Sciences |
| Address |
Bengaluru Karnataka India |
| Type of Sponsor |
Other [UG research grant ] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Archana K |
Alvas Anandamaya Arogyadhama |
Department of Yoga room no 10 Shobhavana campus Mijar Moodabidri
Dakshina Kannada
KARNATAKA |
9448152915
dr.archanabnys@yahoo.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional ethical committee for human studies Alvas college of naturopathy and yogic sciences |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Healthy Human Volunteers |
Healthy individuals who exposed to air pollution. |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Gritha neti |
Stand with legs apart such that body weight is evenly distributed between the two feet. Lean forward and tilt the head to the right side and insert the nozzle in the left nostril. Slightly open the mouth to facilitate respiration through the oral cavity. Maintain a state of relaxation throughout the body, allowing the liquid to expel from the right nostril. When you have used half of the water, remove the nozzle, remain bending forward, align the head centrally and let the water run out of the nose. Close the right nostril with the fingers and blow gently through the left nostril so that all the remaining water comes out. Practice in the same way passing the liquid through the right nostril. It is important to remove all the water after the practice so irritation of the sinuses and mucous membrane does not occur. The liquid should be warm saline water for Jala neti and warm ghee to practice Ghrita neti. It is advisable to practice kapalbhati pranayama after Neti practice. This will dry the nose and generate heat in the nostrils. KAPALABHATI : Sit in any comfortable meditative posture such that spine is erect, close the eyes and relax. Place the hands in either jnana or chin mudra. Inhale deeply and perform rapid respirations through both nostrils placing more emphasis on exhalation. Upon completing the final exhalation, take a deep breath in through the nose and swiftly exhale through mouth, slightly pursing the lips.
Duration: 3 times a week for 1 month. |
| Comparator Agent |
Jala neti |
Stand with legs apart such that body weight is evenly distributed between
the two feet. Lean forward and tilt the head to the right side and insert the
nozzle in the left nostril. Slightly open the mouth to facilitate respiration
through the oral cavity. Maintain a state of relaxation throughout the body,
allowing the liquid to expel from the right nostril. When you have used
half of the water, remove the nozzle, remain bending forward, align the
head centrally and let the water run out of the nose. Close the right nostril
with the fingers and blow gently through the left nostril so that all the
remaining water comes out.
Practice in the same way passing the liquid through the right nostril.
It is important to remove all the water after the practice so irritation of the
sinuses and mucous membrane does not occur.
The liquid should be warm saline water for Jala neti and warm ghee to
practice Ghrita neti. It is advisable to practice kapalbhati pranayama after
Neti practice. This will dry the nose and generate heat in the nostrils.
KAPALABHATI : Sit in any comfortable meditative posture such that
spine is erect, close the eyes and relax. Place the hands in either jnana or
chin mudra. Inhale deeply and perform rapid respirations through both
nostrils placing more emphasis on exhalation. Upon completing the final
exhalation, take a deep breath in through the nose and swiftly exhale
through mouth, slightly pursing the lips.
Duration: 3 times a week for 1 month.
|
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
60.00 Year(s) |
| Gender |
Both |
| Details |
1. Participants must be professional drivers (e.g., auto-rickshaw drivers, cab
drivers, delivery personnel) who are regularly exposed to vehicular
emissions and spend significant time on the road.
2. 18 to 60 years old
3. Participants should have no pre-existing chronic respiratory
conditions (e.g., asthma, COPD, or lung cancer) at the time of
enrolment to avoid confounding effects on the respiratory
microbiota.
4. Participants should not have undergone nasal or sinus surgery
within the last 6 months, as this could affect the nasal microbiome.
5. Individuals who are willing to participate in the study. |
|
| ExclusionCriteria |
| Details |
1. Participants who have had a respiratory infection (e.g., cold, flu, sinusitis)
within the last 4 weeks will be excluded, as infections can temporarily alter
the respiratory microbiota.
2. Subjects allergic to ghee
3. Participants on antibiotics within the last 3 months, as antibiotics can
significantly alter the respiratory microbiota.
4. Smokers, as smoking can significantly alter the respiratory
microbiota
5. Participants who are unwilling to adhere to the study protocol, including
regular practice of Ghrita Neti or Jala Neti.
|
|
|
Method of Generating Random Sequence
|
Coin toss, Lottery, toss of dice, shuffling cards etc |
|
Method of Concealment
|
An Open list of random numbers |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
| Respiratory microbiome |
Pre assessment
Post assessment |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| Nil |
Nil |
|
|
Target Sample Size
|
Total Sample Size="20"
Sample Size from India="20"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
Phase 1/ Phase 2 |
|
Date of First Enrollment (India)
|
10/03/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0"
Months="6"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Yet Recruiting |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
This study helps to know about effect of gritha neti and jala neti on respiratory microbiome Drivers who exposed to air pollution, there will be respiratory microbiome dysbiosis. Hence after practicing neti regularly may be helpful in correcting dysbiosis |