Children presenting with respiratory distress frequently require both oxygen therapy and nebulization. In routine practice, these interventions are delivered using separate devices, which may lead to interruption of oxygen delivery, increased treatment time, and logistical challenges, particularly in emergency settings.This randomized, double-blinded, parallel-group controlled trial aims to evaluate the clinical outcomes of an integrated nebuliser-cum-oxygen mask compared to conventional sequential oxygen and nebulization therapy in pediatric patients with mild to moderate respiratory distress. A total of 150 children aged 1 month to 12 years attending the Department of Paediatrics at Saveetha Medical College and Hospital will be enrolled and randomly allocated to either the intervention group or the control group.The primary outcomes include time to symptom relief, stability of oxygen saturation during therapy, and overall recovery time. Secondary outcomes will assess cost-effectiveness, user satisfaction, and the incidence of adverse events. By combining two essential respiratory interventions into a single, low-cost, and easy-to-use device, this study seeks to improve treatment efficiency, enhance patient safety, and reduce healthcare burden, particularly in emergency and resource-limited pediatric care settings.