| CTRI Number |
CTRI/2025/12/099918 [Registered on: 29/12/2025] Trial Registered Prospectively |
| Last Modified On: |
24/12/2025 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Drug
Homeopathy |
| Study Design |
Single Arm Study |
|
Public Title of Study
|
Individualized homoeopathic treatment for people suffering from migraine and its effect on migraine-related disability |
|
Scientific Title of Study
|
EFFECTIVENESS OF INDIVIDUALISED HOMOEOPATHIC MEDICINE IN
THE TREATMENT OF MIGRAINE ASSESSED USING THE
MIGRAINE DISABILITY ASSESSMENT TEST |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr JANAKARAPALLE JAYAKRISHNA |
| Designation |
PG Scholar |
| Affiliation |
JIMS Homoeopathic Medical College And Hospital |
| Address |
OPD no 2 Department of Organon of Medicine and Homoeopathic Philosophy JIMS Homoeopathic Medical College And Hospital Sriramnagar Muchintal Village
NIL
Hyderabad
TELANGANA
509325
India |
| Phone |
9550150899 |
| Fax |
04023470444 |
| Email |
jaykrishnakarthikeyan@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr kalpavalli Kandada |
| Designation |
Professor |
| Affiliation |
JIMS Homoeopathic Medical College And Hospital |
| Address |
OPD no 2 Department of Organon of Medicine and Homoeopathic Philosophy JIMS Homoeopathic Medical College And Hospital Sriramnagar Muchintal Village
NIL
Hyderabad
TELANGANA
509325
India |
| Phone |
9848366620 |
| Fax |
04023470444 |
| Email |
valli.kandada@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Dr JANAKARAPALLE JAYAKRISHNA |
| Designation |
PG Scholar |
| Affiliation |
JIMS Homoeopathic Medical College And Hospital |
| Address |
OPD no 2 Department of Organon of Medicine and Homoeopathic Philosophy JIMS Homoeopathic Medical College And Hospital Sriramnagar Muchintal Village
NIL
TELANGANA
509325
India |
| Phone |
9550150899 |
| Fax |
04023470444 |
| Email |
jaykrishnakarthikeyan@gmail.com |
|
|
Source of Monetary or Material Support
|
| JIMS Homoeopathic Medical College and Hospital |
|
|
Primary Sponsor
|
| Name |
JIMS Homoeopathic Medical College And Hospital |
| Address |
OPD no 2 Department of Organon of Medicine and Homoeopathic Philosophy JIMS Homoeopathic Medical College And Hospital Sriramnagar Muchintal Village |
| Type of Sponsor |
Private medical college |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr JANAKARAPALLE JAYAKRISHNA |
JIMS Homoeopathic Medical College And Hospital |
OPD no 2 Department of Organon of Medicine and Homoeopathic Philosophy JIMS Homoeopathic Medical College And Hospital Sriramnagar Muchintal Village
NIL
Hyderabad
TELANGANA |
09550150899
04023470444
jaykrishnakarthikeyan@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| JIMS Homoeopathic Medical College and Hospital |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: G43||Migraine, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Individualised homoeopathic medicine |
Medicines will be prescibed based on the selected similimum from the selected Totality with selected dose. |
| Comparator Agent |
NIL |
NIL |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
50.00 Year(s) |
| Gender |
Both |
| Details |
Migraine without Aura Common Migraine
Migraine with Aura Classic Migraine
Patients willing to participate in the study and giving written informed consent |
|
| ExclusionCriteria |
| Details |
Patients with other chronic headache disorders
Pregnant and other lactation ladies
Patients with pathological conditions of Brain
Immunocompromised patients |
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
To understand the efficacy of individualised Homoeopathic
medicine assessed with Change in Midas questionnaire score from baseline to 3 months post
Treatment and improving the quality of life a patient |
Baseline and 3 months |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
Change in migraine frequency attacks of episodes of migraine
from baseline to 3 months post intervention of homoeopathic Treatment |
Baseline and 3 months |
|
|
Target Sample Size
|
Total Sample Size="30"
Sample Size from India="30"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
Phase 2 |
|
Date of First Enrollment (India)
|
15/01/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1"
Months="0"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Migraine is a common and disabling neurological disorder characterized by recurrent episodes of moderate to severe headache often associated with nausea vomiting and sensitivity to light and sound It significantly affects daily activities work productivity and quality of life Conventional treatments may provide symptomatic relief but are often associated with side effects or limited long term benefits Homoeopathy being a holistic and individualized system of medicine aims to treat the patient as a whole by addressing physical mental and emotional aspects This prospective interventional study aims to evaluate the effectiveness of individualized homoeopathic medicine in the treatment of migraine using the Migraine Disability Assessment MIDAS questionnaire Thirty patients diagnosed with migraine aged 18 to 50 years will be selected from the outpatient and inpatient departments of JIMS Homoeopathic Medical College and Hospital Individualized homoeopathic remedies will be prescribed based on detailed case taking and totality of symptoms Changes in MIDAS scores and frequency of migraine attacks will be assessed over a three month follow up period to determine improvement in migraine related disability and quality of life |