| CTRI Number |
CTRI/2025/12/099603 [Registered on: 22/12/2025] Trial Registered Prospectively |
| Last Modified On: |
19/12/2025 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Drug
Homeopathy |
| Study Design |
Single Arm Study |
|
Public Title of Study
|
A Study to Assess the Effectiveness of Individualised Homoeopathic Treatment for Pain Management in Patients with Knee Osteoarthritis |
|
Scientific Title of Study
|
STUDY THE EFFECTIVENESS OF INDIVIDUALISED HOMOEOPATHIC
MEDICINE IN PAIN MANAGEMENT IN OSTEOARTHRITIS OF KNEE USING
OXFORD KNEE SCORE [OKS] |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr Pokala Sharanya |
| Designation |
PG Scholar |
| Affiliation |
JIMS Homoeopathic Medical College and Hospital |
| Address |
OPD No 2 Department of Organon of Medicine JIMS Homoeopathic Medical College and Hospital
Sriramnagar(muchintala), palmakula (Post), shamshabad, R.R. dist, Hyderabad, Telangana
OPD No 2 Department of Organon of Medicine JIMS Homoeopathic Medical College and Hospital
Sriramnagar(muchintala), palmakula (Post), shamshabad, R.R. dist, Hyderabad, Telangana
Hyderabad
TELANGANA
509325
India |
| Phone |
09100673674 |
| Fax |
04023470444 |
| Email |
pokalasharanya@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr Jayanta Pal |
| Designation |
Professor |
| Affiliation |
JIMS HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL |
| Address |
JIMS HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL
Sriramnagar(muchintala), palmakula (Post), shamshabad, R.R. dist, Hyderabad, Telangana
JIMS HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL
Sriramnagar(muchintala), palmakula (Post), shamshabad, R.R. dist, Hyderabad, Telangana
Hyderabad
TELANGANA
509325
India |
| Phone |
7003445153 |
| Fax |
04023470444 |
| Email |
jayantapal1968@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Dr Pokala Sharanya |
| Designation |
PG Scholar |
| Affiliation |
JIMS Homoeopathic Medical College and Hospital |
| Address |
JIMS Homoeopathic Medical College and Hospital
Sriramnagar(muchintala), palmakula (Post), shamshabad, R.R. dist, Hyderabad, Telangana
JIMS Homoeopathic Medical College and Hospital
Sriramnagar(muchintala), palmakula (Post), shamshabad, R.R. dist, Hyderabad, Telangana
Hyderabad
TELANGANA
509325
India |
| Phone |
09100673674 |
| Fax |
04023470444 |
| Email |
pokalasharanya@gmail.com |
|
|
Source of Monetary or Material Support
|
|
|
Primary Sponsor
|
| Name |
JIMS Homoeopathic Medical College and Hospital |
| Address |
JIMS Homoeopathic Medical College and Hospital
Sriramnagar(muchintala), palmakula (Post), shamshabad, R.R. dist, Hyderabad, Telangana |
| Type of Sponsor |
Private medical college |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Pokala Sharanya |
JIMS Homoeopathic Medical College and Hospital |
JIMS Homoeopathic Medical College and Hospital
Sriramnagar(muchintala), palmakula (Post), shamshabad, R.R. dist, Hyderabad, Telangana
Hyderabad
TELANGANA |
09100673674
04023470444
pokalasharanya@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| IECJIMS |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: M179||Osteoarthritis of knee, unspecified, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Individualised Homoeopathic medicine |
Based on the requirement Individualised Homoeopathic medicine is given one dose in powder form or pills form for every 21 days |
| Comparator Agent |
NIL |
NIL |
|
|
Inclusion Criteria
|
| Age From |
40.00 Year(s) |
| Age To |
80.00 Year(s) |
| Gender |
Both |
| Details |
Patients of both sexes, above 40 years of age.
Patients with osteoarthritis of knee joint [ICD-11 FA01] based on X-ray and clinical findings grade 1 to grade 3 OA knee are included. |
|
| ExclusionCriteria |
| Details |
Patients who were having other rheumatic diseases.
Patients who had a history of knee injury and who had undergone knee surgery
were also excluded.
Patients with osteoarthritis of knee with oxford knee score 0 are excluded.
Patients suffering from severe systemic diseases with complications or who are in need for emergency intervention. |
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
To evaluate the change of pain and functionality in osteoarthritis of knee using
Oxford Knee Score. |
for every 21+/-7 days for 6months |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| NIL |
NIL |
|
|
Target Sample Size
|
Total Sample Size="30"
Sample Size from India="30"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
Phase 2 |
|
Date of First Enrollment (India)
|
15/01/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1"
Months="0"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Yet Recruiting |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Osteoarthritis of the knee is a common degenerative joint disorder causing pain, stiffness, and functional limitation, especially in individuals above 40 years of age. Conventional treatments provide symptomatic relief but are associated with adverse effects on long-term use. This observational clinical study aims to assess the effectiveness of individualised homoeopathic medicines in pain management of knee osteoarthritis using the Oxford Knee Score (OKS). A total of 30 patients with radiologically confirmed grade I–III osteoarthritis of the knee will be enrolled through purposive sampling from the OPD, IPD, and outreach camps of JIMS Homoeopathic Medical College and Hospital. Individualised homoeopathic treatment will be prescribed based on totality of symptoms, along with physiotherapy. The Oxford Knee Score will be assessed at baseline and during follow-up over six months. Statistical analysis will be done to evaluate changes in pain and functional status. |