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CTRI Number  CTRI/2026/01/102040 [Registered on: 27/01/2026] Trial Registered Prospectively
Last Modified On: 26/01/2026
Post Graduate Thesis  No 
Type of Trial  Observational 
Type of Study   Cohort Study 
Study Design  Single Arm Study 
Public Title of Study   Knee Phenotyping Prior To Total Knee Arthroplasty : Can We Eliminate The Need of Long Leg Radiographs With An Imageless Robotic System? 
Scientific Title of Study   Knee Phenotyping Prior To Total Knee Arthroplasty : Can We Eliminate The Need of Long Leg Radiographs With An Imageless Robotic System? 
Trial Acronym  RATKA 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Adit Maniar 
Designation  Consultant Orthopaedic Surgeon 
Affiliation  Lilavati Hospital and Research Centre 
Address  Department of Orthopaedics, A-791, Bandra Reclamation Rd, General Arunkumar Vaidya Nagar, Bandra West, Mumbai, Maharashtra 400050
Department of Orthopaedics, A-791, Bandra Reclamation Rd, General Arunkumar Vaidya Nagar, Bandra West, Mumbai, Maharashtra 400050
Mumbai
MAHARASHTRA
400054
India 
Phone  9920010666  
Fax    
Email  aditmaniar@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Adit Maniar 
Designation  Consultant Orthopaedic Surgeon 
Affiliation  Lilavati Hospital and Research Centre 
Address  A-791, Bandra Reclamation Rd, General Arunkumar Vaidya Nagar, Bandra West, Mumbai, Maharashtra 400050
A-791, Bandra Reclamation Rd, General Arunkumar Vaidya Nagar, Bandra West, Mumbai, Maharashtra 400050
Mumbai
MAHARASHTRA
400054
India 
Phone  9920010666  
Fax    
Email  aditmaniar@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Adit Maniar 
Designation  Consultant Orthopaedic Surgeon 
Affiliation  Lilavati Hospital and Research Centre 
Address  A-791, Bandra Reclamation Rd, General Arunkumar Vaidya Nagar, Bandra West, Mumbai, Maharashtra 400050
A-791, Bandra Reclamation Rd, General Arunkumar Vaidya Nagar, Bandra West, Mumbai, Maharashtra 400050
Mumbai
MAHARASHTRA
400054
India 
Phone  9920010666  
Fax    
Email  aditmaniar@gmail.com  
 
Source of Monetary or Material Support  
Lilavati Hospital and Research Centre, Department of Orthopaedics, A-791, Bandra Reclamation Rd, General Arunkumar Vaidya Nagar, Bandra West, Mumbai, Maharashtra, 400050, India 
 
Primary Sponsor  
Name  Dr. Adit Maniar 
Address  Dr. Maniars Clinic, 2nd Floor, S.V. Road, Santacruz (West), Mumbai-400054. 
Type of Sponsor  Other [Principal Investigator] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Adit Maniar  Lilavati Hospital & Research Centre  Department of Orthopaedics, A-791 Bandra Reclamation Road, Bandra West, Mumbai - 400050, Maharashtra, India
Mumbai (Suburban)
MAHARASHTRA 
9920010666

aditmaniar@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
LILAVATI HOSPITAL AND RESEARCH CENTRE, ETHICS COMMITTEE FOR BIOMEDICAL AND HEALTH RESEARCH  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M179||Osteoarthritis of knee, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  90.00 Year(s)
Gender  Both 
Details  i. Undergoing Primary unilateral or bilateral Robotic assisteted total knee arthroplasty
ii. Able to stand without support preoperatively
iii. Agreeing to participate in the study
 
 
ExclusionCriteria 
Details  i. Undergoing revision or unicompartmental knee arthroplasty
ii. Previous injury to lower limb leading to an extra articular deformity
iii. Unable to stand without support preoperatively
iv. Not willing to participate
 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To study the correlation between hip-knee-ankel angle, mechanical medial proximal tibial angle and mechanical lateral distal femoral angle measured by
a) preoperative long leg radiographs
b) intraoperative positioning of implants
c) postoperative processing of data by engineers using exact measured cartilage thickness.
 
Preoperative, Intraoperative and postoperative processing of data between 1-2 weeks after surgery 
 
Secondary Outcome  
Outcome  TimePoints 
NIL  NIL 
 
Target Sample Size   Total Sample Size="50"
Sample Size from India="50" 
Final Enrollment numbers achieved (Total)= "50"
Final Enrollment numbers achieved (India)="50" 
Phase of Trial   N/A 
Date of First Enrollment (India)   09/02/2026 
Date of Study Completion (India) 22/06/2026 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Date Missing 
Estimated Duration of Trial   Years="0"
Months="5"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Completed 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

a)      Background: Robot Assisted Total Knee Arthroplasty (RA TKA) has been shown to have increased accuracy and precision [1,2]. In recent years we have better understood the importance of  knee phenotypes based on bony morphology on the outcomes of TKA [3-5]. There are multiple different systems used to classify these knee phenotypes [6,7]. All of them use three main angle measurements: hip-knee-ankle angle (HKA), mechanical medial proximal tibial angle (mMPTA) and mechanical  lateral distal femoral angle (mLDFA). To measure these parameters, we need a standing long leg radiograph. However, this involves increased radiation exposure and can be time consuming.

b)     Lacunae / Justification : Currently, there is no alternative to long leg radiographs for the measurement of these three angles. We have developed a way to measure these parameters intraoperatively and postoperative processing of the data by the engineering team. So far there is no study validating the use of this technique to measure these angles. By validating our technique, our aim is to eliminate the need of preoperative long leg radiographs to measure these parameters.

 
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