FULL DETAILS (Read-only)  -> Click Here to Create PDF for Current Dataset of Trial
CTRI Number  CTRI/2026/01/102488 [Registered on: 29/01/2026] Trial Registered Prospectively
Last Modified On: 03/01/2026
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Drug
Preventive
Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Multiple Arm Trial 
Public Title of Study   Dextrose versus Triamcinolone Injection for Carpal Tunnel Syndrome Relief 
Scientific Title of Study   A Randomized Controlled Trial Comparing the Efficacy of Five Percent Dextrose and Triamcinolone Hydrodissection for Carpal Tunnel Syndrome 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Ravi Gaur 
Designation  Additional Professor 
Affiliation  All India Institute Of Medical Sciences Jodhpur  
Address  Room 15 PMR Block AIIMS Jodhpur Near OPD Complex Heavy Industrial Area Phase II Basni Jodhpur Rajasthan

Jodhpur
RAJASTHAN
342005
India 
Phone  8299711753  
Fax    
Email  ravisms80@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Ravi Gaur 
Designation  Additional Professor 
Affiliation  All India Institute Of Medical Sciences Jodhpur  
Address  Room 15 PMR Block AIIMS Jodhpur Near OPD Complex Heavy Industrial Area Phase II Basni Jodhpur Rajasthan


RAJASTHAN
342005
India 
Phone  8299711753  
Fax    
Email  ravisms80@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Ravi Gaur 
Designation  Additional Professor 
Affiliation  All India Institute Of Medical Sciences Jodhpur  
Address  Room 15 PMR Block AIIMS Jodhpur Near OPD Complex Heavy Industrial Area Phase II Basni Jodhpur Rajasthan


RAJASTHAN
342005
India 
Phone  8299711753  
Fax    
Email  ravisms80@gmail.com  
 
Source of Monetary or Material Support  
AIIMS Jodhpur ,marudar hi industrial area second phase, Basni, Jodhpur, Rajasthan 342005 
 
Primary Sponsor  
Name  AIIMS Jodhpur 
Address  PMR Block , AIIMS Jodhpur ,marudar hi industrial area second phase, Basni, Jodhpur, Rajasthan 342005 
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Ujwal Veluguleti  AIIMS Jodhpur  PMR Block Room 15 , Marudar Hi Industrial Area, Second Phase, Basni, Jodhpur, Rajasthan 342005
Jodhpur
RAJASTHAN 
9581881995

veluguletiujwal@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
INSTITUTIONAL HUMAN ETHICS COMMITTEE, All India Institute of Medical Sciences Basni Jodhpur   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: G560||Carpal tunnel syndrome,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Ultrasound guided median nerve hydrodissection using five percent dextrose.   Dextrose group will receive a single 10 millilitre perineural injection prepared by mixing 2 millilitres of 25 percent dextrose, 3 millilitres of 2 percent lidocaine, and 5 millilitres of normal saline. The injection will be administered once under ultrasound guidance for hydrodissection of the median nerve at the carpal tunnel inlet using an in-plane ulnar approach with a 26-gauge needle. Five millilitres of the injectate will be delivered above the median nerve to separate it from the flexor retinaculum and five millilitres below the nerve to separate it from the flexor tendons. Total duration of intervention: single session; follow-up assessments at 1 and 3 months. 
Comparator Agent  Ultrasound guided median nerve hydrodissection using forty milligrams per milliliter triamcinolone acetate.  Triamcinolone group will receive a single 10 millilitre perineural injection prepared by mixing 1 millilitre of triamcinolone acetonide 40 milligrams per millilitre, 3 millilitres of 2 percent lidocaine, and 6 millilitres of normal saline. The injection will be administered once under ultrasound guidance for hydrodissection of the median nerve at the carpal tunnel inlet using an in-plane ulnar approach with a 26-gauge needle. Five millilitres will be injected above the nerve and five millilitres below. Total duration of intervention: a single session, with follow-up assessments at 1 and 3 months. 
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  80.00 Year(s)
Gender  Both 
Details  Patients diagnosed with mild to moderate carpal tunnel syndrome based on electrophysiological studies and meeting the following criteria.
Primary symptom includes nocturnal paresthesia or dysesthesia in the affected hand, possibly associated with hand posture, overuse, or relief by shaking the hand, also known as the flick sign.
At least one of the following features must be present.
Numbness in the median nerve sensory distribution of the hand.
Weakness with atrophy of the thenar muscles.
Positive Phalen’s sign or Tinel’s sign. 
 
ExclusionCriteria 
Details  Pre existing neurological conditions such as polyneuropathy, brachial plexopathy, or thoracic outlet syndrome.
Recent wrist surgery.
Inflammatory conditions such as rheumatoid arthritis, hypothyroidism, or other rheumatological disorders.
Pregnancy.
Uncontrolled diabetes mellitus.
Current warfarin use or previous steroid injections at the wrist.
Any trauma, tumor, or infection at the injection site.
Allergy to corticosteroids or lidocaine. 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   An Open list of random numbers 
Blinding/Masking   Participant and Investigator Blinded 
Primary Outcome  
Outcome  TimePoints 
Visual analog scale (VAS)  base line 1 month and 3 month 
 
Secondary Outcome  
Outcome  TimePoints 
boston carpal tunnel questionnaire  base line 1 month and 3 month 
cross sectional area of median nerve in ultrasound   base line 1 month 3 month 
nerve conduction studies   base line 1 month and 3 month 
grip strength of hand  base line 1 month and 3 month 
 
Target Sample Size   Total Sample Size="110"
Sample Size from India="110" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 4 
Date of First Enrollment (India)   30/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="9"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Carpal Tunnel Syndrome is the most common entrapment neuropathy resulting from compression of the median nerve within the carpal tunnel, leading to pain, numbness, and weakness in the hand. Hydrodissection, an ultrasound guided technique, separates the median nerve from surrounding tissues to relieve compression and improve nerve mobility. This double blind randomized controlled trial aims to compare the efficacy of five percent dextrose in water and triamcinolone forty milligrams per milliliter hydrodissection in patients with mild to moderate Carpal Tunnel Syndrome. A total of 110 participants, 55 in each group, will be recruited from the Department of Physical Medicine and Rehabilitation at the All India Institute of Medical Sciences, Jodhpur. Group A will receive a 10 milliliter injectate of five percent dextrose in water, consisting of 2 milliliters of 25 percent dextrose, 3 milliliters of two percent lidocaine, and 5 milliliters of normal saline. Group B will receive 10 milliliters of triamcinolone preparation, consisting of 1 milliliter triamcinolone, 3 milliliters of two percent lidocaine, and 6 milliliters of normal saline. Injections will be performed under ultrasound guidance using an in plane ulnar approach. Outcomes including pain score using visual analog scale, Boston Carpal Tunnel Syndrome Questionnaire, ultrasound measured cross sectional area, nerve conduction studies, and grip strength will be assessed at baseline, 1 month, and 3 months. Five percent dextrose in water hydrodissection is hypothesized to provide longer lasting pain relief and functional improvement compared to triamcinolone.

 
Close