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CTRI Number  CTRI/2026/02/105025 [Registered on: 27/02/2026] Trial Registered Prospectively
Last Modified On: 26/02/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   A Study to Compare Task-Oriented Training With and Without Proprioceptive Neuromuscular Facilitation on Arm Function in People With chronic Stroke 
Scientific Title of Study   Effects of task oriented training with or without propioceptive neuromuscular facilitaion replication technique on upper extremity motor function in chronic ischemic stroke subjects: a randomized clinical trial 
Trial Acronym  nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Agrareema Sharma PT 
Designation  Post Graduate Student 
Affiliation  Pandit Deendayal Upadhyaya National Institute for Persons with Physical Disabilities (Divyangjan) 
Address  Department of Physiotherapy,Pandit Deendayal Upadhyaya National Institute for Persons with Physical Disabilities (Divyangjan),4-Vishnu Digamber Marg,New Delhi,India ,110002

New Delhi
DELHI
110002
India 
Phone  7352924869  
Fax    
Email  agrareemasharma2201@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Manju Vats Phd  
Designation  Lecturer PT 
Affiliation  Pandit Deendayal Upadhyaya National Institute for Persons with Physical Disabilities (Divyangjan) 
Address  Department of Physiotherapy,Pandit Deendayal Upadhyaya National Institute for Persons with Physical Disabilities (Divyangjan),4-Vishnu Digamber Marg,New Delhi,India ,110002

New Delhi
DELHI
110002
India 
Phone  9891182228  
Fax    
Email  manju.vats@rediffmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Manju Vats Phd  
Designation  Lecturer PT 
Affiliation  Pandit Deendayal Upadhyaya National Institute for Persons with Physical Disabilities (Divyangjan) 
Address  Department of Physiotherapy,Pandit Deendayal Upadhyaya National Institute for Persons with Physical Disabilities (Divyangjan),4-Vishnu Digamber Marg,New Delhi,India ,110002

New Delhi
DELHI
110002
India 
Phone  9891182228  
Fax    
Email  manju.vats@rediffmail.com  
 
Source of Monetary or Material Support  
Pandit Deendayal Upadhyaya National Institute for Persons with Physical Disabilities (Divyangjan),4 Vishnu Digamber Marg,New Delhi 
 
Primary Sponsor  
Name  nil 
Address  nil 
Type of Sponsor  Other [Rehabilitation Instituute ] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Manju Vats  Pandit Deendayal Upadhyaya National Institute for Persons with Physical Disabilities (Divyangjan)  Department of Physiotherapy ,Pandit Deendayal Upadhyaya National Institute for Persons with Physical Disabilities (Divyangjan),4-Vishnu Digamber Marg ,New Delhi,110002
New Delhi
DELHI 
9891182228

manju.vats@rediffmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethics Committee PDUNIPPD  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: I634||Cerebral infarction due to embolism of cerebral arteries, (2) ICD-10 Condition: I633||Cerebral infarction due to thrombosis of cerebral arteries,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Task Oriented Training and Conventional Physiotherapy  The control group will receive task-oriented training and conventional physiotherapy only, without PNF replication.Group will undergo intervention sessions of 45–60 minutes duration, 3–5 days per week, for 4 weeks, totaling 20 sessions.  
Intervention  Task Oriented Training and Proprioceptive Neuromuscular facilitation replication Technique and conventional physiotherapy  The experimental group will receive task-oriented training combined with upper extremity Proprioceptive Neuromuscular Facilitation (PNF) replication technique along with conventional physiotherapy. Functional upper-limb tasks such as reaching, hand-to-mouth activity, and supination–pronation will be performed using PNF replication to facilitate motor control and functional recovery. Group will undergo intervention sessions of 45–60 minutes duration, 3–5 days per week, for 4 weeks, totaling 20 sessions.  
 
Inclusion Criteria  
Age From  40.00 Year(s)
Age To  65.00 Year(s)
Gender  Both 
Details  1.Subjects with Unilateral Chronic Ischemic Stroke, with middle cerebral artery involvement confirmed with MRI or CT scan.
2.Both genders, having age range between 40-65 years.
3.Subject with Brunnstrom Voluntary Motor Control of Upper extremity more than or equal to 3.
4.Subjects with good trunk control and able to sit independently.
5.Subjects with Mini Mental State Examination (MMSE) score more than or equal to 24.
 
 
ExclusionCriteria 
Details  1.Subjects other than cerebral stroke e.g Cerebellar, pontine or brain stem stroke.
2.Subjects with hemorrhagic or recurrent stroke.
3.Subjects with other brain disorders like subarachnoid hemorrhage, encephalitis, epilepsy, transient ischemic attack (TIA), or brain injury.
4.Subjects with heart failure symptoms, uncontrolled hypertension, or unstable angina.
5.Subjects having cognitive dysfunction, psychiatric disorder or not able to follow commands.
6.Subjects with musculoskeletal dysfunction in upper extremity like fracture, tendon, or muscle injury.
 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Sequentially numbered, sealed, opaque envelopes 
Blinding/Masking   Outcome Assessor Blinded 
Primary Outcome  
Outcome  TimePoints 
Fugl Meyer Assessment of upper extremity (FMA-UE).  Measurements will be taken at two time points: at baseline and after completion of 20 intervention sessions.
 
 
Secondary Outcome  
Outcome  TimePoints 
Modified Functional Reach Test (MFRT)  Measurements will be taken at two time points: at baseline and after completion of 20 intervention sessions.
 
Box and Block Test (BBT)  Measurements will be taken at two time points: at baseline and after completion of 20 intervention sessions.
 
Motricity Index (MI)  Measurements will be taken at two time points: at baseline and after completion of 20 intervention sessions.
 
 
Target Sample Size   Total Sample Size="40"
Sample Size from India="40" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   09/03/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Stroke is a leading cause of long-term disability, with chronic ischemic stroke survivors frequently experiencing persistent upper extremity motor impairments that limit functional independence and quality of life.

This study is a randomized clinical trial designed to evaluate the effectiveness of task-oriented training with and without Proprioceptive Neuromuscular Facilitation (PNF) replication technique on upper extremity motor function in individuals with chronic ischemic stroke. Stroke survivors often experience long-term upper limb motor impairments that limit functional independence and quality of life, making effective rehabilitation strategies essential.

A total of 40 participants with chronic unilateral ischemic stroke will be recruited and randomly allocated into two groups. The experimental group will receive task-oriented training combined with upper extremity PNF replication technique, while the control group will receive task-oriented training and conventional physiotherapy alone. Both groups will undergo intervention sessions lasting 45–60 minutes, 3–5 days per week, for a total duration of 4 weeks (20 sessions).

Outcome measures used to assess upper limb motor function include the Modified Functional Reach Test (MFRT), Box and Block Test (BBT), Fugl-Meyer Assessment for Upper Extremity (FMA-UE), and Motricity Index (MI). Assessments will be conducted at baseline and after completion of 20 intervention sessions.

The study aims to determine whether the addition of PNF replication technique to task-oriented training provides superior improvements in upper extremity motor function compared to task-oriented training alone. The findings are expected to contribute evidence for integrating PNF replication techniques into rehabilitation protocols for chronic ischemic stroke survivors.

 
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