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CTRI Number  CTRI/2026/01/101583 [Registered on: 19/01/2026] Trial Registered Prospectively
Last Modified On: 19/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Observational 
Type of Study   Cross Sectional Study 
Study Design  Other 
Public Title of Study   Yoga versus Non Yoga : Who Ages Slower Biologically? 
Scientific Title of Study   A Comparative Cross-sectional Study of Biological age between Regular Yoga Practicing Individuals and Non-Practicing Individuals with special reference to Phenotypic Age Biomarkers. 
Trial Acronym  Nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Supriya BipinKumar Singh 
Designation  BAMS MD Scholar [ PG Student ] 
Affiliation  Government Ayurved College and Hospital Nagpur 
Address  OPD no 06 Swastharakshan Department Government Ayurved College and Hospital Sakkardara square Raje Raghuji Nagar Nagpur 440024 Maharashtra India
OPD no 06 Swastharakshan Department Government Ayurved College and Hospital Sakkardara square Raje Raghuji Nagar Nagpur 440024 Maharashtra India
Nagpur
MAHARASHTRA
440024
India 
Phone  9284759162  
Fax    
Email  supriyasingh1612@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Manjiri V Bhende 
Designation  Associate Professor  
Affiliation  Government Ayurved College and Hospital , Nagpur 
Address  Plot no 104 Near Sarveshwar Mandir Dattatray Nagar Ayodhya Nagar Nagpur Maharashtra India
OPD no 06 Swastharakshan Department Government Ayurved College and Hospital Sakkardara square Raje Raghuji Nagar Nagpur 440024 Maharashtra India
Nagpur
MAHARASHTRA
440024
India 
Phone  9373127925  
Fax    
Email  manjiri.palnitkar@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Supriya BipinKumar Singh 
Designation  BAMS MD Scholar [ PG Student] 
Affiliation  Government Ayurved College and Hospital, Nagpur 
Address  OPD no 06 Swastharakshan Department Government Ayurved College and Hospital Sakkardara square Raje Raghuji Nagar Nagpur 440024 Maharashtra India
OPD no 06 Swastharakshan Department Government Ayurved College and Hospital Sakkardara square Raje Raghuji Nagar Nagpur 440024 Maharashtra India
Nagpur
MAHARASHTRA
440024
India 
Phone  9284759162  
Fax    
Email  supriyasingh1612@gmail.com  
 
Source of Monetary or Material Support  
Periphery of Government Ayurved College and Hospital Nagpur Maharashtra India 440024 ( recruited under OPD 06 of Government Ayurved Hospital Nagpur  
 
Primary Sponsor  
Name  Supriya BipinKumar Singh  
Address  OPD 06 , Swastharakshan Department Government Ayurved Collrge and Hospital , Nagpur Maharashtra 440022 
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Supriya Singh  Government Ayurved College , Nagpur and its periphery as well as yoga centres  OPD 06 ,Swastharakshan Department , Government Ayurved College, Sakkardhara Square, Raje Raghuji Nagar , umred Road Nagpur , Maharashtra 440024
Nagpur
MAHARASHTRA 		 9284759162

supriyasingh1612@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethics Committee Government Ayurved College , Nagpur  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  Healthy human volunteers 
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
Intervention  Nil  Nil 
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  30.00 Year(s)
Age To  50.00 Year(s)
Gender  Both 
Details  1)Individuals between 30-50 years of age , irrespective of gender , education , religion and socioeconomic status.
2) Clinically healthy individuals , with no chronic Systemic illness ( e.g., diabetes , hypertension,cardiovascular disease , autoimmune disorders) will be included.
3) Individuals who have been practicing yoga regularly Since 1 year , with minimum frequency of 3 sessions per week, and each session last long for 30-45 minutes.
4) Body mass index between 18.5 and 25 to minimise confounding effects of underweight or obesity on phenotypic aging.
5) Participants who consume outside or restaurant- prepared food not more than 4 to 6 times a month , and maintain primarily home-cooked meals during the weekdays
6) Not engaged in high level athletic training or competitive sports.
7) Willing to provide written informed consent and comply with all study procedures, including interviews , sampling for phenotypic age biomarkers and questionnaires.
8) Low to moderate IPAQ Score (i.e., less than 3000 MET-minutes per week ) for non yoga practitioners.
 
 
ExclusionCriteria 
Details  1) Individuals younger than 30 years or older than 50 years at the time of recruitment
2) Diagnosis of any chronic medical condition , including diabetes mellitus , hypertension , cardiovascular diseases, chronic respiratory conditions ( e.g.,asthma , COPD ), autoimmune disorders, thyroid dysfunction , cancer
3) Recent major surgery or hospitalisation within the last 6 months.
4) Individuals taking long term medications.
5) Engaging in yoga for less than 1 years .
6) High IPAQ-SQ Score ( more than 3000 MET-minutes per week )for non yoga practitioners.
7) Individuals involved in intensive physical training, such as professional athletes or those regularly engaged in high performance fitness routine ( e.g., cross fit, marathon training ) as these may independently influence biological aging.
8) History of Alcohol abuse or substance abuse .
9) Underweight ( BMI less than18.5 ) or obese (BMI more than 25 )
10) Subjects who are unable to give consent.
 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To Compare the biological age between yoga practitioners and non practitioners assessed by Phenotypic age biomarkers .
 		 1 YEAR 
 
Secondary Outcome  
Outcome  TimePoints 
1)To assess the biological age among regular yoga practitioners using phenotypic age biomarkers.
2)To assess the biological age among non practitioners using phenotypic age biomarkers .
3)To evaluate analytical difference between the International Physical Activity Questionnaire–Short Form (IPAQ-SF)among healthy yoga practitioners and non practitioners. 		 1 year 
 
Target Sample Size   Total Sample Size="108"
Sample Size from India="108" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   19/04/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="5" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

This comparative cross-sectional study assesses biological age differences using phenotypic age biomarkers (9 blood markers: albumin, creatinine, glucose, CRP, etc.) between 54 regular yoga practitioners (more than or equal to 1 year, 3 sessions per week) and 54 non-practitioners, aged 30-50, in Nagpur. Healthy participants, matched by age/gender, undergo lab tests and IPAQ-SF questionnaires . Statistical analysis (t-tests) will evaluate yoga’s impact on aging, hypothesizing lower biological age in practitioners amid rising lifestyle diseases.

 
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