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CTRI Number  CTRI/2026/03/105230 [Registered on: 02/03/2026] Trial Registered Prospectively
Last Modified On: 01/03/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   Effectiveness of Extracoporeal shockwave therapy versus ultrasound therapy on functional ability, pain and range of motion in grade 2 & 3 knee osteoarthritis 
Scientific Title of Study   Effectiveness of Extracoporeal shockwave therapy versus ultrasound therapy on functional ability, pain and range of motion in patients with grade 2 & 3 knee osteoarthritis 
Trial Acronym  ESWT-UST-FPRO 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Abhishek 
Designation  MPT Student 
Affiliation  Pandit Deendayal Upadyaya National Institute for Person with Physical Disabilities (Divyangjan) 
Address  4, Vishnu Digamber Marg, New Delhi-110002

New Delhi
DELHI
110002
India 
Phone  9643971718  
Fax    
Email  abhishektomer82@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Mrs Rajni Kalra 
Designation  Assistant Professor PT 
Affiliation  Pandit Deendayal Upadyaya National Institute for Person with Physical Disabilities (Divyangjan) 
Address  4, Vishnu Digamber Marg, New Delhi-110002

New Delhi
DELHI
110002
India 
Phone  9599833554  
Fax    
Email  rajnikalra70@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Mrs Rajni Kalra 
Designation  Assistant Professor PT 
Affiliation  Pandit Deendayal Upadyaya National Institute for Person with Physical Disabilities (Divyangjan) 
Address  4, Vishnu Digamber Marg, New Delhi-110002

New Delhi
DELHI
110002
India 
Phone  9599833554  
Fax    
Email  rajnikalra70@gmail.com  
 
Source of Monetary or Material Support  
NIL 
 
Primary Sponsor  
Name  NIL 
Address  NIL 
Type of Sponsor  Other [Rehabilitation and academic Institute] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Abhishek  Pandit Deendayal Upadyaya National Institute for Person with Physical Disabilities (Divyangjan)  4, Vishnu Digamber Marg, New Delhi-110002
New Delhi
DELHI 
9643971718

abhishektomer82@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Instutional Ethics Committee Pandit Deendayal Upadhyaya National Institute For Persons With Physical Disabilities (Divyangjan)  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Approved/Obtained 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M179||Osteoarthritis of knee, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Extracorporeal Shockwave Therapy  Once per week For 4 Weeks with Conventional knee Exercises 
Comparator Agent  Ultrasound Therapy  5 days Per week For 4 weeks with conventional Knee Exercises 
 
Inclusion Criteria  
Age From  45.00 Year(s)
Age To  70.00 Year(s)
Gender  Both 
Details  1.Diagnosed with Knee Osteoarthritis (Grade 2 or 3) according to the Kellgren and Lawrence scale, as diagnosed by an experienced orthopedician.
2. Age range: 45-70 years.
3. Chronic knee pain
4. Ability to complete all outcome measures.
 
 
ExclusionCriteria 
Details  1. Other Joint Disorders affecting mobility w
2. Recent Knee Surgery within the past 6 months or have a prosthetic knee joint
3. Other Musculoskeletal Conditions that affect gait or mobility will be excluded.
4. Cardiovascular or Systemic Conditions
5. Use of Medications
6. Inability to Follow Protocol 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Other 
Blinding/Masking   Investigator Blinded 
Primary Outcome  
Outcome  TimePoints 
Lower Extremity Functional Scale (LEFS)  At Baseline and after 4 weeks 
 
Secondary Outcome  
Outcome  TimePoints 
Numeric Pain Rating Scale  At Baseline and after 4 weeks 
Range of Motion (ROM)  At Baseline and after 4 weeks 
Time Up and Go Test (TUG)  At Baseline and after 4 weeks 
 
Target Sample Size   Total Sample Size="44"
Sample Size from India="44" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   13/03/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Knee osteoarthritis is a common degenerative joint disorder that leads to pain, reduced range of motion, and difficulty in performing daily activities. Physiotherapy interventions play an important role in the conservative management of knee osteoarthritis. Among various treatment options, Extracorporeal Shock Wave Therapy (ESWT) and Ultrasound Therapy (US) are frequently used modalities; however, limited evidence is available comparing their effectiveness.

This randomized clinical trial aims to compare the effectiveness of Extracorporeal Shock Wave Therapy and Ultrasound Therapy on functional ability, pain, and range of motion in patients with Grade 2 and Grade 3 knee osteoarthritis. A total of 40 participants diagnosed with Grade 2 and 3 knee osteoarthritis will be randomly allocated into two groups. The experimental group will receive ESWT once a week for four weeks, while the control group will receive Ultrasound Therapy five days a week for four weeks. Both groups will also receive a standardized exercise program as part of routine physiotherapy care.

Outcome measures will be assessed at baseline and after completion of the four-week intervention period. The findings of this study may help in identifying a more effective physiotherapy intervention for improving functional outcomes in patients with knee osteoarthritis.
 
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