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CTRI Number  CTRI/2026/01/100870 [Registered on: 12/01/2026] Trial Registered Prospectively
Last Modified On: 12/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Ayurveda 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Panchakarma procedure and ayurvedic medicine in the management of Eka Kushtha w.s.r. to Psoriasis 
Scientific Title of Study   A comparative study to evaluate the efficacy of Neem Patra Lepa with and without Virechana in the management of Eka Kushtha w.s.r. to Psoriasis 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Simran 
Designation  PG Scholar 
Affiliation  Dayanand Ayurvedic College, Jalandhar 
Address  Department of Panchakarma Dayanand Ayurvedic College and Hospital, Mahatma Hans Raj Marg, Jalandhar, Punjab, India

Jalandhar
PUNJAB
144008
India 
Phone  8264813419  
Fax    
Email  simran190499@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Parveen Kumar 
Designation  Professor and HOD of Panchakarma 
Affiliation  Dayanand Ayurvedic College, Jalandhar  
Address  Department of Panchakarma Dayanand Ayurvedic College and Hospital, Mahatma Hans Raj Marg, Jalandhar, Punjab, India

Jalandhar
PUNJAB
144008
India 
Phone  7589303536  
Fax    
Email  drparv1@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Simran 
Designation  PG Scholar 
Affiliation  Dayanand Ayurvedic College, Jalandhar  
Address  Department of Panchakarma Dayanand Ayurvedic College and Hospital, Mahatma Hans Raj Marg, Jalandhar, Punjab, India

Jalandhar
PUNJAB
144008
India 
Phone  8264813426  
Fax    
Email  simran190499@gmail.com  
 
Source of Monetary or Material Support  
Dayanand Ayurvedic College and Hospital, Mahatma Hans Raj Marg, Jalandhar, Punjab, 144008, India 
 
Primary Sponsor  
Name  Dayanand Ayurvedic College and Hospital, Jalandhar 
Address  Department of Panchakarma, Dayanand Ayurvedic College and Hospital, Mahatma Hans Raj Marg, opp Burlton Park, Jalandhar, Punjab, 144008, India 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Simran  Dayanand Ayurvedic College and Hospital, Jalandhar  Department of Panchakarma, Dayanand Ayurvedic College and Hospital, Mahatma Hans Raj Marg, Jalandhar, Punjab, 144008, India
Jalandhar
PUNJAB 		 08264813426

simran190499@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
DAC Institutinal Ethics Committee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:L400||Psoriasis vulgaris. Ayurveda Condition: EKAKUSHTHAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmDrugClassical(1) Medicine Name: Neem Patra Lepa, Reference: Charak Sutra 3/3, Route: Topical, Dosage Form: Churna/ Powder, Dose: 50(g), Frequency: od, Bhaishajya Kal: Adhobhakta, Duration: 30 Days, anupAna/sahapAna: No, Additional Information: Dried Neem Patra is made into a fine powder. Before local application on the body, it is mixed with Sarsharpa Tail (Mustard oil) and made into soft paste.
2Comparator ArmProcedure-virecana-karma, विरेचन-कर्म (Procedure Reference: Charak Chikitsa 7/41, Procedure details: Ama Pachana will be carried out by using Chitrakadi vati in a dose of 1 tablet 3 times a day before food with warm water until Nirama lakshanas appear.Subsequently, Abhayantara Snehana with Mahatikta ghrita will be administered as Snehapana early in the morning (between 6:30-7:30 am) on an empty stomach in Arohana karma, until the appearance of Samyaka Snigdha Lakshana. Here, Anupana of Snehapana will be lukewarm water. Dose will be decided as per status of Kostha and Agni of the patient. After the appearance of Samyaka Snigdha lakshana, Sarvanga Abhyanga with Murchita Tila Taila followed by Bashpasweda, will be done for 3 days. On the day of Shodhana, Virechana will be done with Triphala kwath along with Trivrut churna and Dantimool churna on an empty stomach, after Sarvanga Abhyanga and Sweda in the morning. Dose will be decided as per status of Koshtha and Agni of the patient. Peyadi Samsarjana karma will be advised for 3-7 days as per Shuddhi Prakara. Maximum Duration for procedure will be 23 days.))
(1) Medicine Name: Triphala kwath along with Trivrut churna and Dantimool churna, Reference: Bhaishajya Ratnavali, Kushtharogadhikar, 54/4, Route: Oral, Dosage Form: Kwatha/Kashaya, Dose: 100(ml), Frequency: od, Duration: 1 Days
 
Inclusion Criteria  
Age From  16.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  1. Patients fulfilling the diagnostic criteria of Eka Kushtha.
2. Patients of all varieties of Psoriasis will be selected.
3. Patient of either sex.
4.Patient between the age group of 16-60 years.
5.Both fresh and treated cases of Eka-Kushtha, which have already discontinued other treatments, will be selected.
6.Patients who are fit for Virechana Karma.
 
 
ExclusionCriteria 
Details  1. Patient with other systemic disorders like uncontrolled Diabetes Mellitus type 2 and Hypertension, which interfere with the treatment.
2. Eka-Kushtha (Psoriasis) with extra cutaneous manifestations.
3. The patient has had chronicity for more than 15 years
 
 
Method of Generating Random Sequence   Random Number Table 
Method of Concealment   Case Record Numbers 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
1. Aswedanam (anhidrosis/ lack of sweating).
2. Mahavastu (broad-based)
3. Matshyashakalopamam (looks like the scales of a fish).
4. Krishana-arun varna (blackish red discoloration). 		 Assessment of the patient will be done on day 1st, 16th, 30th and 45th 
 
Secondary Outcome  
Outcome  TimePoints 
1. Auspitz Sign
2. Candle grease sign
3. PASI Score 		 Assessment of the patient will be done on day 1st, 16th, 30th and 45th 
 
Target Sample Size   Total Sample Size="60"
Sample Size from India="60" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 2 
Date of First Enrollment (India)   23/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   Psoriasis is a chronic inflammatory skin disorder with increasing prevalence. Modern treatments such as corticosteroids, methotrexate, cyclosporine, and biologics are effective, but their long-term use is associated with adverse effects, including hepatotoxicity, nephrotoxicity, immunosuppression, and increased economic burden, limiting their sustained use. Whereas, Ayurveda Panchakarma therapies have a bright scope in managing psoriasis. Psoriasis is correlated with Kushtha, involving predominant Vata and Kapha dosha vitiation. This study will be undertaken to evaluate an alternative Ayurvedic approach. In this trial, we are evaluating the effect of Neem patra lepa with and without Virechana in the management of Eka Kushtha w.s.r. Psoriasis with the aim to develop and evaluate a new treatment modality for this disease. 
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