FULL DETAILS (Read-only)  -> Click Here to Create PDF for Current Dataset of Trial
CTRI Number  CTRI/2025/12/099685 [Registered on: 22/12/2025] Trial Registered Prospectively
Last Modified On: 20/12/2025
Post Graduate Thesis  Yes 
Type of Trial  Observational 
Type of Study   Prospective 
Study Design  Other 
Public Title of Study   Clinical, EEG, and MRI Features of Afebrile Focal Seizures in Children 
Scientific Title of Study   A study of clinical profile, electroencephalographic (EEG) characteristics and magnetic resonance imaging (MRI) findings of afebrile focal seizures in children. 
Trial Acronym  Nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Anagha Srikanth 
Designation  Junior resident  
Affiliation  Kasturba Medical College 
Address  Department of Paediatrics, Kasturba Medical College, Madhavnagar, Manipal.

Udupi
KARNATAKA
576104
India 
Phone  9113665040  
Fax    
Email  anagahsrikanth2599@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Ramesh Bhat Y 
Designation  Professor and Head of Department of Paediatrics. 
Affiliation  Kasturba Medical College 
Address  Department of Paediatrics, Kasturba Medical College, Madhavnagar, Manipal.

Udupi
KARNATAKA
576104
India 
Phone  9686401313  
Fax    
Email  docrameshbhat@yahoo.co.in  
 
Details of Contact Person
Public Query  
Name  Dr Anagha Srikanth 
Designation  Junior resident  
Affiliation  Kasturba Medical College 
Address  Department of Paediatrics, Kasturba Medical College, Madhavnagar, Manipal.

Udupi
KARNATAKA
576104
India 
Phone  9113665040  
Fax    
Email  anagahsrikanth2599@gmail.com  
 
Source of Monetary or Material Support  
NIL 
 
Primary Sponsor  
Name  Dr Ramesh Bhat Y 
Address  Kasturba Medical College Madhav nagar, Manipal, Udupi district, Karnataka, India. PIN code 576104  
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Anagha Srikanth  Kasturba Medical College and Hospital  Department of Paediatrics, Kasturba Medical College and Hospital, Manipal
Udupi
KARNATAKA 		 9113665040

anaghasrikanth2599@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Kasturba Medical College and Kasturba Hospital Institutional Ethics Committee 2  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: G400||Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, (2) ICD-10 Condition: G402||Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, (3) ICD-10 Condition: G401||Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Nil  Nil 
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  1.00 Month(s)
Age To  18.00 Year(s)
Gender  Both 
Details  Children aged 1 month to 18 years with afebrile focal seizures  
 
ExclusionCriteria 
Details  1. Children with afebrile focal seizures in whom imaging could not be obtained.
2. Children with afebrile focal seizures following head injury, nuerosurgery or RTA. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
The primary outcome is to study and analyse the clinical profile, electroencephalographic (EEG) characteristics and magnetic resonance imaging (MRI) findings of afebrile focal seizures in children.   At baseline, primary visit. 
 
Secondary Outcome  
Outcome  TimePoints 
Nil  Nil 
 
Target Sample Size   Total Sample Size="50"
Sample Size from India="50" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   02/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="1" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Focal seizures (previously known as partial seizures) are caused by electrical discharges that originate in one hemisphere of the brain and cause symptoms based on the neuronal area they affect. There are two subtypes of focal seizure, categorized based on whether or not the seizures affect consciousness. 

Focal aware seizure (previously simple partial seizure) and Focal impaired awareness seizure (previously complex partial seizure).


Early and accurate diagnosis of focal seizures in children is crucial, as it directly influences treatment decisions, prognosis, and quality of life. A detailed clinical history, electroencephalography (EEG), and neuroimaging—particularly magnetic resonance imaging (MRI) of brain help in further diagnosis.


By systematically analyzing the clinical profile, EEG characteristics, and MRI findings in children with focal seizures, this study aims to better understand diagnostic consistency and support evidence-based approaches to management.

It will also help identify patterns of presentation that can prompt early investigation, improve prognosis, and potentially reduce the burden of uncontrolled epilepsy in children.

 
Close