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CTRI Number  CTRI/2026/01/100079 [Registered on: 01/01/2026] Trial Registered Prospectively
Last Modified On: 26/12/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Yoga & Naturopathy 
Study Design  Randomized, Parallel Group, Multiple Arm Trial 
Public Title of Study   Effect of yoga and hare krishna mahamantra 
Scientific Title of Study   DECIPHERING YOGA AND HARE KRISHNA MAHA MANTRA ON PHYSIOLOGICAL AND SPIRITUAL ALTERATIONS IN URBAN POPULATION 
Trial Acronym  YAMA-UP 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  sakshi 
Designation  PhD scholar 
Affiliation  Amity institute of indian system of medicines  
Address  Amity Institute of Indian System of Medicine, F3 Block,
Amity University Uttar Pradesh, Sector–125, Noida – 201301, Uttar Pradesh, India.
Gautam Buddha Nagar
UTTAR PRADESH
201313
India 
Phone  07011419739  
Fax    
Email  sakshiipal17@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr sanjay singh 
Designation  Associate Professor & Head of Institution (HOI) 
Affiliation  Amity institute of indian system of medicines  
Address  Amity Institute of Indian System of Medicine, F3 Block
Amity University Uttar Pradesh, Sector–125, Noida – 201301, Uttar Pradesh, India
Gautam Buddha Nagar
UTTAR PRADESH
201313
India 
Phone  9368116267  
Fax    
Email  ssingh65@amity.edu  
 
Details of Contact Person
Public Query  
Name  Sakshi 
Designation  PhD Scholar, 
Affiliation  Amity Institute of Indian System of Medicine, Amity University Uttar Pradesh, Noida, India 
Address  Amity Institute of Indian System of Medicine, F3 Block
Amity University Uttar Pradesh, Sector–125, Noida – 201301, Uttar Pradesh, India
Gautam Buddha Nagar
UTTAR PRADESH
201301
India 
Phone  7011419739  
Fax    
Email  sakshi30@s.amity.edu  
 
Source of Monetary or Material Support  
nil 
 
Primary Sponsor  
Name  Sakshi Selffunded 
Address  Amity Institute of Indian System of Medicine, F3 Block, Amity University Uttar Pradesh, Sector 125, Noida 201301, Uttar Pradesh, India. 
Type of Sponsor  Other [self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Sanjay Singh  Amity University Uttar Pradesh  Yoga Hall, G Block 1st floor, Amity Institute of Indian System of Medicine, Amity University Uttar Pradesh, Sector 125, Noida 201301, Uttar Pradesh, India.
Gautam Buddha Nagar
UTTAR PRADESH 		 09448262298

ssingh65@amity.edu 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
“Institutional Ethics Committee, Amity University Uttar Pradesh”  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Approved/Obtained 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  population should belongs to urban area(specifically Delhi and Delhi NCR) 
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  control group kept waitlisted  12 weeks of observation for samples who are following there daily normal lifestyle 
Intervention  YOGA protocol and Mantra chanting  International yoga day protocol and Hare krishna mahamantra chanting for 12 weeks  
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details 
All Subjects should be residents of Urban area, specifically from Delhi and Delhi
NCR.
Have ability to understand Hindi or English language
Be physically and mentally stable, as assessed by general health questionnaire(we
are using for screening samples).
Provide Informed consent and committed to voluntarily participate in 12 weeks of
YOGA intervention and assessments.
Have access to a smartphone/internet connection if in case they are unable to
attend offline sessions. Not be currently practicing regular Yoga or Mantra chanting in any structured
way 
 
ExclusionCriteria 
Details   
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   On-site computer system 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
To assess the changes in spiritual well being after practicing Yoga and
Hare Krishna Mahamantra.
 		 13 weeks
 
 
Secondary Outcome  
Outcome  TimePoints 
To analyse physiological changes after practicing Yoga and Hare Krishna Mahamantra.  13weeks 
 
Target Sample Size   Total Sample Size="300"
Sample Size from India="300" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   10/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Public Title of the Study

Deciphering the effects of Yoga and Hare Krishna Mahamantra on physiological psychological and spiritual alterations in urban populations

Scientific Title of the Study

Deciphering Yoga and Hare Krishna Mahamantra on physiological psychological and spiritual alterations in urban populations of Delhi and Delhi NCR A quasi experimental four arm pre post study

Brief Summary

Urban populations experience increasing levels of stress anxiety lifestyle related physiological disturbances and spiritual disconnection. Yoga and mantra chanting are traditionally known to promote holistic well being. Existing literature suggests that Hare Krishna Mahamantra chanting enhances sattva guna and reduces stress depression rajas and tamas. However no study has systematically compared the isolated and combined effects of Yoga and Hare Krishna Mahamantra chanting on physiological psychological and spiritual parameters.

This study is designed to evaluate and compare the effects of Yoga alone Hare Krishna Mahamantra alone their combined practice and no intervention on physiological psychological and spiritual variables among urban adults. A quasi experimental four arm pre post study design will be employed with a total sample of 400 participants equally distributed across four groups. The intervention period will be twelve weeks. Outcomes will be assessed using validated physiological measures and standardized psychometric scales.

Objectives of the Study

Primary Objective
To evaluate the isolated and combined effects of Yoga and Hare Krishna Mahamantra on physiological psychological and spiritual parameters in urban adults

Secondary Objectives
To assess changes in blood pressure heart rate oxygen saturation and respiratory rate following Yoga and Hare Krishna Mahamantra practice
To assess changes in spiritual well being using the Daily Spiritual Experience Scale and Spiritual Well Being Scale
To assess changes in depression anxiety stress and psychological well being using DASS 21 and WHO 5 Well Being Index
To compare outcomes between Yoga only Mantra only combined Yoga and Mantra and control groups

Study Design

Quasi experimental four arm pre post study

Study Setting

Urban areas of Delhi and Delhi NCR India

Duration of the Study

Twelve weeks of intervention with pre intervention and post intervention assessments

Sample Size

A total of 400 participants will be recruited with 100 participants in each group based on G power sample size calculation with effect size 0.56 alpha error 0.05 and power 0.95

Study Population

Male and female participants aged 20 to 60 years residing in urban areas of Delhi and Delhi NCR

Inclusion Criteria

Participants aged between 20 and 60 years
Residents of urban areas of Delhi and Delhi NCR
Ability to understand Hindi or English
Physically and mentally stable as assessed by a general health questionnaire
Willingness to provide informed consent and participate for twelve weeks
Access to smartphone or internet if unable to attend offline sessions
Not practicing regular Yoga or Mantra chanting in a structured manner

Exclusion Criteria

Age below 20 years or above 60 years
Diagnosed major psychiatric disorders such as schizophrenia or bipolar disorder
Presence of chronic diseases such as cardiovascular disease diabetes respiratory disorders or thyroid disorders
Participants on regular medication
History of substance abuse
Pregnant or lactating women

Intervention Details

Group A Experimental Group
Participants will practice Yoga for 35 to 45 minutes followed by Hare Krishna Mahamantra chanting for 10 minutes equivalent to 108 rounds daily for twelve weeks

Group B Active Control Group 1
Participants will practice Yoga only for 35 to 45 minutes daily for twelve weeks

Group C Active Control Group 2
Participants will practice Hare Krishna Mahamantra chanting only for 10 minutes equivalent to 108 rounds daily for twelve weeks

Group D Control Group
Participants will receive no intervention and will be waitlisted

Outcome Measures

Physiological Parameters
Blood pressure heart rate oxygen saturation and respiratory rate measured using digital blood pressure monitor pulse oximeter and standard respiratory rate assessment

Psychological Parameters
Depression anxiety and stress measured using Depression Anxiety Stress Scale 21
Psychological well being measured using WHO Five Well Being Index

Spiritual Parameters
Daily Spiritual Experience Scale
Spiritual Well Being Scale

Socioeconomic Status
Modified Kuppuswamy Socioeconomic Scale

Assessment Timeline

Baseline assessment will be conducted before the intervention
Post intervention assessment will be conducted after completion of twelve weeks

Statistical Analysis Plan

Data will be entered and analyzed using SPSS or R software
Descriptive statistics will summarize participant characteristics
Baseline comparisons will be performed using chi square test ANOVA or Kruskal Wallis test
Within group comparisons will be analyzed using paired t test or Wilcoxon signed rank test
Between group comparisons will be analyzed using one way ANOVA with Tukey post hoc test or Kruskal Wallis test with Dunn correction
Time and group interaction effects will be assessed using two way repeated measures ANOVA
Correlation between physiological psychological and spiritual variables will be assessed using Pearson or Spearman correlation
Statistical significance will be set at p less than 0.05

Ethics Statement

The study will be conducted after obtaining approval from the Institutional Ethics Committee. Written informed consent will be obtained from all participants prior to enrollment. Participation will be voluntary and confidentiality of data will be maintained.

Expected Outcomes

The study is expected to demonstrate that the combined practice of Yoga and Hare Krishna Mahamantra produces greater improvements in physiological psychological and spiritual well being compared to isolated practices and no intervention. The findings may provide scientific evidence for integrating mantra chanting with Yoga in holistic health promotion programs.
 
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