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CTRI Number  CTRI/2025/12/099883 [Registered on: 29/12/2025] Trial Registered Prospectively
Last Modified On: 25/12/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   A Study of People with Front Knee Pain: Comparing Hands-On Muscle Release and Foam Rolling for Reducing Pain and Improving Knee Movement and Leg Flexibility 
Scientific Title of Study   Comparison between Effect of Myofascial Release and Foam Roller on Pain, Range of Motion of Knee Joint, Flexibility of Hamstring and Iliotibial Band in Patients with Patellofemoral Pain Syndrome: An Experimental Study 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL   NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Aditi Vijay Kadam  
Designation  PG student  
Affiliation  TMVs Lokmanya Tilak College of Physiotherapy  
Address  TMVs Lokmanya Tilak College of Physiotherapy Third floor Department of Musculoskeletal Physiotherapy Block J Raghunath Vihar Sector 14 Kharghar Navi Mumbai

Raigarh
MAHARASHTRA
410210
India 
Phone  7039760439  
Fax    
Email  aditikadam0926@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Ruturaj Shete 
Designation  Associate Professor  
Affiliation  TMVs Lokmanya Tilak College of Physiotherapy  
Address  TMVs Lokmanya Tilak College of Physiotherapy Third floor Department of Musculoskeletal Physiotherapy Block J Raghunath Vihar Sector 14 Kharghar Navi Mumbai

Raigarh
MAHARASHTRA
410210
India 
Phone  9870881008  
Fax    
Email  ruturaj.53@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Ruturaj Shete 
Designation  Associate Professor  
Affiliation  TMVs Lokmanya Tilak College of Physiotherapy  
Address  TMVs Lokmanya Tilak College of Physiotherapy Third floor Department of Musculoskeletal Physiotherapy Block J Raghunath Vihar Sector 14 Kharghar Navi Mumbai

Raigarh
MAHARASHTRA
410210
India 
Phone  9870881008  
Fax    
Email  ruturaj.53@gmail.com  
 
Source of Monetary or Material Support  
TMVs Lokmanya Tilak College of Physiotherapy Third Floor Department of Musculoskeletal Physiotherapy Sector 14 Near Raghunath Vihar Kharghar Navi Mumbai 
 
Primary Sponsor  
Name  TMVs Lokmanya Tilak College of Physiotherapy 
Address  Plot No 3 Block J Raghunath Vihar Sector 14 Kharghar Navi Mumbai- 410210 
Type of Sponsor  Research institution 
 
Details of Secondary Sponsor  
Name  Address 
TMVs Lokmanya Tilak College of Physiotherapy  Plot No 3 Block J Raghunath Vihar Sector 14 Kharghar Navi Mumbai- 410210 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Aditi Vijay Kadam   TMVs Lokmanya Tilak College of Physiotherapy   TMVs Lokmanya Tilak College of Physiotherapy Third Floor Department of Musculoskeletal Physiotherapy Block J Raghunath Vihar Sector 14 Kharghar -410210 Navi Mumbai
Raigarh
MAHARASHTRA 
7039760439

aditikadam0926@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
TMVs Lokmanya Tilak College of Physiotherapy Institutional Ethics Committee (Academic)  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M222||Patellofemoral disorders,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Foam Rolling   Foam Rolling to Hamstring and Iliotibial Band.Conventional treatment includes stretching of the lower limb muscles and strengthening of hip and knee muscles.Above treatment is given for thrice a week for 4 week. Total duration: 30 minutes 
Comparator Agent  Myofascial Release   Myofascial Release to Hamstring and Iliotibial Band.Conventional treatment includes stretching of the lower limb muscles and strengthening of hip and knee muscles.Above treatment is given for thrice a week for 4 week. Total duration: 40 minutes 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  45.00 Year(s)
Gender  Both 
Details  1) Reproduction of Retro patellar and Peripatellar pain while walking stairs squatting running cycling or sitting with flexed knee.
2) Positive patellar tilt test.
3) Moderate pain Intensity 3-7 on VAS Scale
4) Age group 18 to 45 years old
5) Both males and females
6) Hamstring and Iliotibial Band Tightness  
 
ExclusionCriteria 
Details  1)Patients with history of History of knee surgery or fracture.
2)Presence of inflammatory or systemic conditions (eg: rheumatoid arthritis).
3) Any other Neurological disorders affecting the lower limb.
4) Pathological conditions of knee involving synovitis Osgood- Schlatter’s disease meniscal or intraarticular conditions.
T5)hose with referred pain from hip back and sacroiliac joint.  
 
Method of Generating Random Sequence   Stratified randomization 
Method of Concealment   Alternation 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
Tightness of Hamstring and Iliotibial Band
Pain
Range of Motion of Knee Joint 
Baseline(Pre Intervention) on Day 1 then after 4 weeks of Intervention (Post Intervention) 
 
Secondary Outcome  
Outcome  TimePoints 
NIL  NIL 
 
Target Sample Size   Total Sample Size="48"
Sample Size from India="48" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 3 
Date of First Enrollment (India)   09/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   This study aims to compare the effectiveness of Myofascial Release and Foam Rolling techniques in patients with Patellofemoral Pain Syndrome. Participants will be randomly assigned to either the Myofascial Release group or the Foam rolling group. Both interventions target the soft tissues around the knee, hamstring, and iliotibial band to reduce pain and tightness.

Outcome Measures:
1) Visual Analogue Scale - It measures the amount of pain that patient feels. The ends are defined as the extreme limits of pain oriented from left (worst) to the right (best) 
2) Range of Motion of Knee Joint- Goniometer will be used to measure the range of motion of Knee Joint.
3) 90-90 Straight Leg Raise Test  - This test is used to assess the flexibility of Hamstring.
4) Modified Ober’s Test – This test is used to assess the flexibility of Ilio-Tibial Band.

Pre-intervention screening and assessment will be done.

GROUP A: Myofascial release and Conventional physiotherapy
(MFR for hamstring) 
• Patient position: Prone lying
• Hamstring area was exposed
• Light stroking using hand over hamstring muscle from proximal to distal of the hamstring (2-3 minutes)
• Compression of the posterior thigh (2-3 minutes)
  Cross hand release technique for hamstring 120seconds, 5 repetition/session.
• Myofascial release is given with ulnar border from proximal to distal direction with light gentle pressure over the hamstring muscle until the slack in the skin is loosened.

(MFR for iliotibial band) 
• Patient position- side lying on unaffected side with hip and knee 30 degree flexed
• Technique- soft fist or elbow used to engage the fasciae at the greater trochanter.
• Then sustain gentle pressure in inferior direction at the line with the fibers of IT band from femur towards the knee.
• This pressure then should be held for 90 seconds followed by 60 seconds of rest period and repeated for 5 minutes.
• Neuromuscular technique (longitudinal stroke)- the thumb is placed over the taut band and longitudinal strokes are applied slowly with moderate pressure; this technique is applied for 3 minutes.

Group B: Foam Rolling and Conventional Physiotherapy
(Foam Rolling for Ilio-Tibial Band) 
• With a roller you can be extremely targeted on the spots that are hot and work up and down its entire length.
• Sit sideways on your roller, then rest your upper bodyweight on your hands.
• Bend the non-rolling leg so the lower section is touching the floor, then slightly straighten it so that the roller moves down from your hip towards your knee.
• This may be the most painful of all the moves you do, but try to keep the roller moving super slow so that you get a prolonged period of squeezing against the muscle.
• When you get close to the bony section of the knee, change direction and repeat.

(Foam Rolling for Hamstring) 
• Sit on top of the roller, with pressure on one leg.
• Your starting point is on the outside of the leg that you are rolling, just behind the knee.
• Place your hands behind you for balance and, as you start the movement, push downwards with your arms.
• Your aim is to let the roller move halfway up the back of your thigh, then as you roll back down towards the start position, make sure you have a subtle corkscrew action so you finish at the outside of your knee.

Conventional Physiotherapy
• Stretching of hamstrings, plantar flexors, quadriceps, iliotibial band 3 reps with 30 second each.
• Iliopsoas strengthening in non weight bearing 3 sets with 10 reps each.
• Seated knee extension 90-45 degree 3 sets with 10 reps each.
• Leg press and squatting 0-45 degree 3 sets with 10 reps each.
• Hip abduction against elastic band(standing) & with weights (side-lying) 3 sets with 10 reps each.
• Hip external rotation against elastic band(sitting) 3 sets with 10 reps each
• Side-stepping against elastic band 3 sets with 10 reps each.
• Maximum resistance will be given that enables 10 repetitions
• Load was 70% of the 1-repetition maximum.
Treatment will be given for 3 days in a week for a period of 4 weeks, total 12 sessions.

Post-Intervention assessment will be done.
Data collected will be analysed and results will be drawn. Based on the results, a conclusion will be given.
 
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