CTRI

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CTRI Number

CTRI/2026/01/100670 [Registered on: 09/01/2026] Trial Registered Prospectively

Last Modified On:

21/07/2026

Post Graduate Thesis

Type of Trial

Observational

Type of Study

Study Design

Other

Public Title of Study

This is a NTproBNP based screening study to understand the prevalence of Heart Failure in high-risk population.

Scientific Title of Study

NTproBNP based screening to understand the prevalence of Heart Failure in high-risk population: the SECURE-HF study.

Trial Acronym

NIL

Secondary IDs if Any

Secondary ID	Identifier
SP/CVD/SECURE-HF/2025,Version No.:1.0,Date: 25/NOV/2025	Protocol Number

Details of Principal Investigator or overall Trial Coordinator (multi-center study)

Name	Dr Chintan Khandhedia
Designation	Team Lead- Clinical Research \| RWE
Affiliation	Sun Pharma Laboratories Limited
Address	Sun Pharma Laboratories Limited, Plot No. 201, B-1, Western Express Highway, Goregaon (E) Mumbai (Suburban) MAHARASHTRA 400063 India
Phone	02243244324
Fax
Email	Chintan.Khandhedia@sunpharma.com

Details of Contact Person
Scientific Query

Name	Dr Neeraj Markandeywar
Designation	General Manager- Medical Affairs & Clinical Research
Affiliation	Sun Pharma Laboratories Limited
Address	Sun Pharma Laboratories Limited, Plot No. 201, B-1, Western Express Highway, Goregaon (E) Mumbai (Suburban) MAHARASHTRA 400063 India
Phone	9022797378
Fax
Email	Neeraj.Markandeywar@sunpharma.com

Details of Contact Person
Public Query

Name	Ms Colette Pinto
Designation	Manager - Clinical Research \| RWE
Affiliation	Sun Pharma Laboratories Limited
Address	Sun Pharma Laboratories Limited, Plot No. 201, B-1, Western Express Highway, Goregaon (E) Mumbai (Suburban) MAHARASHTRA 400063 India
Phone	02243244324
Fax
Email	Colette.Pinto@sunpharma.com

Source of Monetary or Material Support

Sun Pharmaceutical Industries Limited (SPIL), SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai - 400063

Primary Sponsor

Name	Sun Pharmaceutical Industries Limited (SPIL)
Address	SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai - 400063
Type of Sponsor	Pharmaceutical industry-Indian

Details of Secondary Sponsor

Name	Address
NA	NA

Countries of Recruitment

India

Sites of Study
Modification(s)

No of Sites = 93
Name of Principal Investigator	Name of Site	Site Address	Phone/Fax/Email
Dr P Sudarshan	Aayush Hospital	48-13-3 3A Ring Road Opp.Siddhartha Medical College, Sri Ramachandra Nagar, Vijayawada, Andhra Pradesh 520008 Krishna ANDHRA PRADESH	9299306237 sudarshanpalaparthi@gmail.com
Dr Rajesh Badani	Aditya Birla Memorial Hospital	Chinchwad, Pune, Maharashtra-411033 Pune MAHARASHTRA	9823818400 drbadanirajesh21@gmail.com
Dr Jeewan Kumar	Advance heart care	Advance heart care,9SCF,MARKET OPPOSITE TAGORE THEATRE ROAD, MODEL TOWN, PATIALA,PUNJAB-147001 Patiala PUNJAB	9781695777 Jeewan.mittal31@gmail.com
Dr Tarun Madan	Ananta Hospital	Ananta Hospital, opp, shaheed major rushikesh ramani garden rd, near rajhans cinemas, new india colony, nikol, ahmedabad, gujarat 380049 Ahmadabad GUJARAT	9824743624 drtarunmadan@yahoo.co.in
Dr Virag Mahorkar	Avanti Institute of Cardiology Pvt. Ltd	Avanti Institute of Cardiology Pvt. Ltd., 5, Abhyankar Marg, Dhantoli, Nagpur, Maharashtra 440012 Nagpur MAHARASHTRA	8007000345 viragmahorkar@gmail.com
Dr Vithal Bagi	BAGI HEART CLINIC	JAYANAGAR, No. 2, Near RV Nursing College, 32nd Cross, Jayanagar 4th Block, Bengaluru - 560011 Bangalore KARNATAKA	9611592145 - drvithaldbagicardio2015@gmail.com
Dr Sonali Sarkar	Bengal Faith Hospital	Bengal Faith Hospital, Health City, Goda, Bardhaman, West Bengal, Burdwan, 713102 Barddhaman WEST BENGAL	9831282752 drsonalisarkar75@gmail.com
Dr VSR Bhupal	Capital Hospital	15-117/1, Vijayawada Rd, Poranki, Vijayawada, Andhra Pradesh 521137 Krishna ANDHRA PRADESH	9885303344 vsrbhupal@gmail.com
Dr Umesh Hange	Cardio Neuro Care Clinic	Cardio Neuro Care Clinic, Sambhaji nagar,431001 Aurangabad MAHARASHTRA	98553 58508 drumesh@gmail.com
Dr Johann Christopher	CARE HOSPITAL	CARE HOSPITAL,4-908/7/1, Musheerabad Main Rd, near Raja Deluxe Theatre, Musheerabad, Bakaram, Kavadiguda, Hyderabad, Telangana 500020 Hyderabad TELANGANA	9701445011 johann1403@gmail.com
Dr Achyuth G	CHEST HOSPITAL	CALICUT, Pavamani Rd, opposite EMS Stadium, Palayam, Kozhikode, Kerala 673004 Kozhikode KERALA	7418895737 - achyu89g@gmail.com
Dr Umesh Jena	Citizen Hospital	Citizen Hospital, Bidhannagar, Durgapur-718212 Barddhaman WEST BENGAL	8249212084 dr.umesh20@gmail.com
Dr Rupesh Kaushik	City Heart Clinic	Shop no 5,6. Rati Ram park, Naya Bazaar, opp. Jyoti Memorial Jain Hospital, Najafgarh, Delhi, 110043 South West DELHI	9744270401 medkaushik@gmail.com
Dr Sanjeev Kalkekar	Cura Clinic	Cura Clinic, New Horizon CHS, Plot no. 1,2 & 3, near Navratna Restaurant, Sector 46, Seawoods, Navi Mumbai, Maharashtra 400706 Mumbai MAHARASHTRA	9930762515 drsanjaykalkekar@gmail.com
Dr Galla Rahgu Kishore	Cygnet Superspeciality Clinics	2ND FLOOR, FAIRMOUNT FORTUNE ONE, Czech Colony, Sanath Nagar, Hyderabad, Telangana 500018 Hyderabad TELANGANA	9848973583 raghukishoregalla@gmail.com
Dr Najeeb Ullah Sofi	Dar Ul Shifa-Heart and Eye Clinic	Dar Ul Shifa-Heart and Eye Clinic, Kaksarai, 1st Floor, Opposite SMHS Emergency Gate, Shreen Bagh Road, Smhs Road, Karan Nagar, Srinagar-190010 Srinagar JAMMU & KASHMIR	7780833050 sofinajeeb@gmail.com
Dr Jogender Singh	DELHI HEART CENTRE,	DELHI HEART CENTRE, Karawal Nagar Main Rd, near Mavi hospital, Nehru Vihar, Old Mustafabad, New Mustafabad, Delhi, 110090 North East DELHI	8076662061 joy.vmmcmbbs@gmail.com
Dr Bhupen Desai	Desai heart care clinic	Desai heart care clinic, level 3, vini elgance, ltt road, above tanishq showroom, mini zaveri bazaar, mhatre wadi, borivali (w), mumbai-400092 Mumbai MAHARASHTRA	9820050840 Bhupendesai@hotmail.com
Dr Chandan Misra	DOCTORS CHAMBER	DOCTORS CHAMBER,BLOCK A2,HOSPITAL ROAD,KALYANI,PIN-741235 Nadia WEST BENGAL	9836983105 drchandan_misra@yahoo.com
Dr Darshan Jhala	Dr Darshan Jhalas Clinic	Dr Darshan Jhalas Clinic & A-201 & 202, Vinay Kum Kum Building, 2nd Floor, Opposite Lalit Restaurant, Off S V Road, Goregaon West, Mumbai-400062 Mumbai MAHARASHTRA	9821010881 Jhala.darshan@gmail.com
Dr Gokul Reddy Mandala	Dr Gokuls Cardiac Clinic	Dr Gokuls Cardiac Clinic, 1-4-56/1, Second Floor, Habsiguda, Hyderabad, Telangana 500007 Hyderabad TELANGANA	9391026973 gokulreddy@yahoo.com
Dr Nimit Shah	Dr Nimit Shah clinic	504,panchratna opera house,14 m p marg,charni road,mumbai-400004 Mumbai MAHARASHTRA	9833951705 drnimitcshah@yahoo.co.uk
Dr Pradeep Kumar K	Dr Pradeep Cardiac Care Centre	Second Floor, Hesarghatta Rd, above MORE SUPERMARKET, opposite RAMACHANDRA HOSPITAL, Havanur Layout, T. Dasarahalli, Bengaluru, Karnataka 560073 Bangalore KARNATAKA	9738620216 doctorpradeep@gmail.com
Dr Umesh Chandra Samal	DR SAMAL CLINIC	KHAZANCHI ROAD MORE YADAV, BHAWAN NAYATOLA, PATNA-800004 Patna BIHAR	9431033123 - drsamalhffi@gmail.com
Dr Somanth Sabale	Dr Somnath Sabale Super Speciality Cardiac Care Centre	Survey No. :- 505, A/27, opposite to Civil Hospital Road, Sadar Bazar, Satara, Maharashtra 415001 Satara MAHARASHTRA	98902 90246 - somnathsable@gmail.com
Dr Akshay Ashok Bafna	Dr. Bafna SuperSpeciality Clinic & Star Hospital	Rukmini Nagar, E ward near LIC ground, Kolhapur, Maharashtra 416005 Kolhapur MAHARASHTRA	91456 83747 - drbafnaakshay@gmail.com
Dr Devendra Kumar Shrimal	Dr. Devendra Heart Care Center	Dr. Devendra Heart Care Center,23,SHIVA COLONY, J P COLONY, TONK PHATAK, JAIPUR, RAJ.- 302015 Jaipur RAJASTHAN	9460200045 devenshrimal@yahoo.co.in
Dr Pankaj jariwala	Dr. Pankaj Heart Care Clinic	1-2-45/1, Badam Galli, Gaganmahal Rd, Domalguda, Hyderabad, Telangana 500029 Hyderabad TELANGANA	9393178738 docpjariwala@yahoo.co.in
Dr Santosh Palled	Dr. Santosh Palled	Dr. Palleds Superspeciality Clinic, 2nd Floor, Gundi Plaza, Gokul Rd, above KVGBANK, beside Shambhavi food court, Apoorva Nagar, Manjunath Nagar, Hubballi, Karnataka 580030 Dharwad KARNATAKA	9082040776 palledclinic@gmail.com
Dr Sujay R	Dr. Sujay’s Heart Care Clinic	Dr. Sujay’s Heart Care Clinic, Anjili Rd, opp. Sankers Hospital, near Kailas Dental Clinic, Kadapakkada, Kollam, Kerala 691001 Kollam KERALA	8606070002 drsujayrenga@gmail.com
Dr P L Saravanan	East point Hospital	Jnana Prabha, East Point Campus, Post, Virgo Nagar, Avalahalli, Bengaluru, Karnataka 560049 Bangalore KARNATAKA	7358326627 plscardiology@outlook.com
Dr Atindranath Bandyopadhyay	Gandhi Memorial Hospital	Kalyani West Bengal-741251 South Twentyfour Parganas WEST BENGAL	9831914225 dratin75@gmail.com
Dr Amit Sharma	Health first Clinic	Health first Clinic & 101, Casablanca, Gulmohar 10th Road, JVPD, Vile Parle West, land mark, opposite Sujay hospital in Juhu, 400049 Mumbai MAHARASHTRA	9821010804 amitthedoc@hotmail.com
Dr A K Thakur	Healthy Heart Clinic	Healthy Heart Clinic, Boring Road, Sri Krishna Puri,Patna- Bihar,800013 Patna BIHAR	9431002343 akthakurforu@gmail.com
Dr Shailender Singh	Heart Clinic	Dr Shailender Singh Heart Clinic, 6-3-668/10/38, Durga Nagar Colony, Punjagutta, Hyderabad, Telangana 500082 Hyderabad TELANGANA	9848022021 shailendersingh.30@gmail.com
Dr Chetan Shah	Heart Rhythm Clinic	Heart Rhythm Clinic, 3rd floor,manu market,MG Road,Ghatkopar west-400084 Mumbai MAHARASHTRA	9821115485 chetanshah@hotmail.com
Dr Soumya Patra	Heart Sugar Clinic and Fertility Centre	Heart Sugar Clinic and Fertility Centre, 120, Street Number 146, BB Block(Newtown), Action Area I, Newtown, Kolkata, New Town, West Bengal-700163 Kolkata WEST BENGAL	9831274230 drsoumya81@gmail.com
Dr Mahesh Aher	Hridayam Heart Care	Hridayam Heart Care, Thakkar Road, Gangapur Road, Deeparati, Nashik-422013 Nashik MAHARASHTRA	8446946045 drmahesh08@gmail.com
Dr A L Narayanan	Idhaya Hert Clinic	Idhaya Hert Clinic, 44 Vidwan Sundaram Street, Tirumurthy Nagar, Nungambakkam-600034 Chennai TAMIL NADU	9841048228 docaln@gmail.com
Dr Anuj Sarda	Intima Hospital	269, Central Bazar Road, near Kachipura Square, New Ramdaspeth, Ramdaspeth, Nagpur, Maharashtra 440010 Nagpur MAHARASHTRA	9823048449 sardaanuj@yahoo.co.in
Dr Ankit Kalra	KALRA HOSPITAL	RAMESH NAGAR, Tulsi Dass Kalra Marg, New Delhi, Delhi 110015 West DELHI	9810120223 kalraankit111@gmail.com
Dr K Srinivasa Reddy	Karumuri Hospital	Karumuri Hospital,38C/13, OLD CLUB ROAD,4TH LINE KOTHA PETA GUNTUR-522001 Guntur ANDHRA PRADESH	9844357856 drsunilbohra@gmail.com
Dr Jay M Shah	Krish Heart Care,Krish Superspeciality Clinic	2 nd Floor Aeon Complex, Opp Navkar Institute, Vijay cross road, Naranpura, Ahmedabad, 380009 Ahmadabad GUJARAT	9898209755 jayshah08@yahoo.co.in
Dr Daya Shankarlal Vaswani	KS General & Heart Clinic	KS General & Heart Clinic ,Plot No 11 to 14, Sy. No. 222P, 4th Floor, Ajay Chandra Complex Above Dr Agarwal Eye Hospital, Madinaguda, Allwyn X Road, Miyapur, Hyderabad, Telangana 500049 Hyderabad TELANGANA	9552455593 dayavaswani@gmail.com
Dr Anil Balachandran	LAKSHMI HOSPITAL	LAKSHMI HOSPITAL, ERNAKULAM, Divans Rd, Pallimukku, Kochi, Ernakulam, Kerala 682016 Ernakulam KERALA	9846212213 dranilbc@yahoo.co.in
Dr Jayagopal Pathiyil Balagopalan	Laxmi Hospital	Room No.3, Block A, Cardiology Department, Ground Floor, Chittur Road, Palakkad, Kerala-678013-India Palakkad KERALA	9847023777 - jaigopallakshmi@gmail.com
Dr Girish B Navasundi	LEGENDS HERAT CLINIC	LEGENDS HERAT CLINIC JAYANAGAR, 1st floor, 37/17, 10th Main Rd, 5th Block, Jayanagar, Bengaluru, Karnataka 560041 Bangalore KARNATAKA	9611099226 navasundi@rediffmail.com
Dr Swapnil D Mate	Lifemate clinic	Lifemate clinic , Good Luck Square, Flat No. 104, Samadhan Apartments, Bhandarkar Rd, beside The Oakwood Hotel, Deccan Gymkhana, Pune-411004 Pune MAHARASHTRA	9819212105 swapnilmate@gmail.com
Dr Jabir Abdullakutty	Lisie Hospital	Lisie Hospital,Lisie Hospital Rd, North Kaloor, Kaloor, Ernakulam, Kerala 682018 Ernakulam KERALA	9447011773 drjabi@yahoo.co.in
Dr Akshay Mahajan	Mahajan Hospital	Mahajan Hospital, Khazana Gate Amritsar,Punjab 143006 Amritsar PUNJAB	9855754339 drakshaymahajan@gmail.com
Dr Debopriyo Mondal	Manipal Hospital	MANIPAL EM BYPASS , 127, Eastern Metropolitan Bypass, Nitai Nagar, Mukundapur, Kolkata, West Bengal 700099 Kolkata WEST BENGAL	9711279626 debopriyo.aiimsrsk2020@gmail.com
Dr Avishek Saha	Manipal Hospitals	Manipal Hospitals, Mukundapur, Kolkata,223 & 230, Barakhola Lane, Purba Jadavpur, Mukundapur, Kolkata 700 099 Kolkata WEST BENGAL	9830185606 avisheksaha72@Gmail.com
Dr Mohammed Asif S	Meds Super Speciality Hospital	Meds Super Speciality Hospital ,11-3-949, opp. Riyan Hotel, Mallepally, Hyderabad, Telangana 500057 Hyderabad TELANGANA	9897820935 mohammed4248asif@gmail.com
Dr Sanjay S Bhat	Mukambika Heart Care	Yelahanka New Town AND Narayana Multispeciality Hospital, NO 809, HIG, Major Sandeep Unnikrishnan Rd, Yelahanka New Town, Bengaluru, Karnataka 560064 Bangalore KARNATAKA	9663603069 - sms.bhat@gmail.com
Dr Nitin Aggarwal	Namya Medical and heart center	F-18/66,Sector-8, Rohini,Delhi, India-110085 North West DELHI	9999868976 Nitinaggarwal222@gmail.com
Dr C Arumugam	Nethra Heart Center	Nethra Heart Center12, 1st Main Road, Balamurugans Garden, Thoraipakkam, Chennai-600097 Chennai TAMIL NADU	9840466160 arumugamcardio@yahoo.com
Dr V Keshava Murthy	NH HOSPITAL	3RD PHASE, DEVANUR,2ND STAGE, R.S.NAIDU NAGAR,MYSORE-570019 Mysore KARNATAKA	9880198850 - drkeshav05@gmail.com
Dr Mainak Mukhopadhyay	NIMITA DIAGNOSTIC CENTER	NIMITA DIAGNOSTIC CENTER, 3 No, Opposite Nimta Old Post, S L Chatterjee Street, Nimta, Kolkata-700049, West Bengal Kolkata WEST BENGAL	9831815122 mainak.nrsmc@gmail.com
Dr Niraml Jain	Nirmal cardiac care	Nirmal cardiac care ground floor, shop no. 26, ski city retail, lake road, opposite Bhandup Police Station, Bhandup w.-400078 Mumbai MAHARASHTRA	7021805673 drnirmal_1979@yahoo.co.in
Dr Shrikant Dhanwale	Nobel Heart Clinic	Nobel Heart Clinic N-3 CH Sambhajinagar-431003 Aurangabad MAHARASHTRA	8454826304 NOBELHEARTCLINIC@GMAIL.COM
Dr Mridul Mahanta	NULIFE SUPERCARE	GUWAHATI, ASSAM, Ahom Gaon, near ISBT & Balaji Temple, on Veer Dwimalu Road, Guwahati, Assam 781034 Kamrup ASSAM	9864070025 - drmridul23@gmail.com
Dr Sanjay Vaghani	P.P. Savani Heart Institute	P.P. Savani Heart Institute, Mansi, Varachha Road, Surat - 395006 Surat GUJARAT	9825153036 drsanjayvaghani@gmail.com
Dr Kushmendra Parashar	PARASHAR HEART CLINIC	PARASHAR HEART CLINIC,226, KANTA CHORAHA, JHOTWARA JAIPUR 302032 Jaipur RAJASTHAN	9414200995 drkparashar@rediffmail.com
Dr S Anandaraja	PARC CLINIC	WRRF+R4X, Chellan Nagar, Raja Rajeswari Nagar, Venkata Nagar, RAINBOW NAGAR, PUDUCHERRY-605011 Pondicherry PONDICHERRY	94880 84379 - s.anandaraja@gmail.com
Dr Ashutosh Kumar	PEARL HEART CLINIC AND DIAGONISTIC CENTRE	Purulia Road, Dangratoli Road, opposite Audi Showroom, Kumhar Toli, Ranchi, Jharkhand 834001 Ranchi JHARKHAND	7755073242 ashutosh2kmed@gmail.com
Dr Ranganathan R M	PRABHU HOSPITAL	NEW SCHEME ROAD,POLLACHI,TAMIL NADU-642001 Coimbatore TAMIL NADU	9894713355 - drranganathanrrm@gmail.com
Dr Biaus Samanta	Prescription Clinic	Prescription Clinic, French Colony, Kulupukur, Panchanan Tala, Chandan nagar, WB-712136 Hugli WEST BENGAL	9007006608 biaussamanta@gmail.com
Dr George Mathew Neerakkal	Rajah Charitable Medical Trust	Rajah Charitable Medical Trust, Chavakkad, Palayur Road, Friendship Nagar, Chavakkad, Kerala, 680506 Thrissur KERALA	9495194785 drgeorgemathewn@hotmail.com
Dr Ravindran R	Rays Clinic	166/8 Sakthi Colony, Shanthi Colony Main Road, 4th Avenue, Anna Nagar West, Chennai-600040 Chennai TAMIL NADU	9840493409 drravindrancardio@gmail.com
Dr Sunil Bohra	Sampath Speciality Clinic	Sampath Speciality Clinic, No. 5/1, 4th Cross Road, Magadi Main Rd, Keshava Nagar, Binnipete, Bengaluru, Karnataka 560023-560023 Bangalore KARNATAKA	9844357856 drsunilbohra@gmail.com
Dr Chandra Prakash Purohit	Sargam Hospital	Sargam Hospital, Main Rd, Shabri Colony, Ayad, Ganapati Nagar, Udaipur, Rajasthan 313001 Udaipur RAJASTHAN	9587509850 drcppurohit@yahoo.co.uk
Dr Ram Naresh Allam	Shanthi Hospital	Shanthi Hospital Omassery, Calicut, Kozhikode, Kerala - 673582 Kozhikode KERALA	9474083337 sheranram@gmail.com
Dr Synrang Warjri	SHILLONG HEART CLINIC,	Nongrim Hills, near Bethany Hospital, in the Banasree area of Shillong, Meghalaya- 793014 East Khasi Hills MEGHALAYA	7308540557 - s.warjri@yahoo.com
Dr Ranabrata Sen	Shubham Hospital & diagnostic centre pvt Ltd	Shubham Hospital & diagnostic centre pvt Ltd. Nara Narayan Road Coochbehar westbengal 736160 Koch Bihar WEST BENGAL	9046323848 senranabrata@gmail.com
Dr D Siva Kumar	SIVA HEART CLINIC	SIVA HEART CLINIC, opp Bhoomatha office, near venkojipalem junction, MVP -colony, Andhra Pradesh-530017 Visakhapatnam ANDHRA PRADESH	8297086168 drdsk67908@gmail.com
Dr Lakshmikanth P	SKANDA HEART CLINIC	715, opposite Shell petrol pump, RBI Layout, JP Nagar 7th Phase, J. P. Nagar, Bengaluru, Karnataka 560078 Bangalore KARNATAKA	9742306268 - drlakshmikanthp@yahoo.co.in
Dr Sachin Rao T	Sri Jayadeva Institite of Cardiovascular Sciences and Research	Sri Jayadeva Institite of Cardiovascular Sciences and Research, kumbarakoppal, gokulam 3rd stage, mahadeshwara badavane layout, mysore-570016 Mysore KARNATAKA	7406552424 rao.sachin86@gmail.com
Dr B Peraiah Chowdary	Sri Krishna Multi Specility Hospital,	Old Club Road, Guntur–522001 Guntur ANDHRA PRADESH	9490639294 peraiah1@yahoo.co.in
Dr Ramesh S	SS Heart Centre	5, Varalakshmi St, Rajeshwari Nagar, Tambaram, Chennai, Tamil Nadu 600073 Chennai TAMIL NADU	99404 95133 sankaranramesh39@Gmail.com
Dr Saranraj J	St. James Hospital	St. James Hospital Chalakudy, Old National Highway, Near Anamala Junction, Chalakudy, Thrissur, Kerala - 680307 Thrissur KERALA	8113873777 sharansamurai2012@gmail.com
Dr Deepan R G	Sugam Hospital	Sugam Hospital, Opp Anna Salai, 144F, Union Office, Rasipuram, Tamil Nadu - 637408 Namakkal TAMIL NADU	9842681222 deeprg84@gmail.com
Dr Debajyoti Datta	Sweet Heart Clinic	Sweet Heart Clinic, Medifolra, Ranibagan, Berhampore, Murshidabad, PIN-742101, West Bengal Murshidabad WEST BENGAL	9474487900 drdebajyotidatta.nrs@gmail.com
Dr Vishal A Poptani	Synergy Circle	Nr Gokulmathura Apartment,Ayodhya Chowk BRTS Stand, 150 Feet Ring Rd, Rajkot, Gujarat 360006 Rajkot GUJARAT	9825078132 - vishpop@hotmail.com
Dr Gautam Swaroop	Tender Palm Super Speciality Hospital	Sector-7, Gomtinagar Extension, Amar Shaheed Path, Near Ekana Stadium Lucknow-226010, Uttar Pradesh, India. Lucknow UTTAR PRADESH	9307852939 drgautam.swaroop@gmail.com
Dr Sameena Khalil	THE HEART CENTRE	THE HEART CENTRE, LAJPAT NAGAR, NEW DELHI, 110024 New Delhi DELHI	9910033807 sameenakhalil@gmail.com
Dr Ashwani Mehta	The Heart Clinic	Shop no. 13,Double story market, New Rajendra Nagar, New Delhi, Delhi - 110060, India New Delhi DELHI	98110 57384 drashwanimehta@gmail.com
Dr Soumitra Kumar	The Heart Clinic	The Heart Clinic Shop no. 13, Double story market, New Rajendra Nagar, New Delhi, Delhi - 110060, India Kolkata WEST BENGAL	9831032519 dr.soumitrakumar@gmail.com
Dr Mahesh Basarge	Tricolour Hospital	Dr. Vikram Sarabhai Road, Genda Cir, Vadiwadi, Vadodara, Gujarat 390023 Vadodara GUJARAT	9825026760 - mahesh_basarge@yahoo.co.in
Dr Priyank Jain	Unique Diagnostic Centre	Unique Diagnostic Centre, In Front of MY Hospital, Indore, MP-452001 Indore MADHYA PRADESH	80853 11000 doctorpriyankjain@gmail.com
Dr A Prem Krishna	VIJAYA HOSPITALS	VIJAYA HOSPITALS &46,COWLEY BROWN ROAD, RS PURAM,COIMBATORE-641002 Coimbatore TAMIL NADU	8861661048 - premkrishna2k1@gmail.com
Dr Subhasish Dey	VIP APEX MEDICAL CENTRE PVT LTD	Joramandir, Baguiati, Kolkata, West Bengal 700159 Kolkata WEST BENGAL	9432850582 subhashis218@gmail.com
Dr P P Mohanan	West Fort Hospital	West Fort Hospital, West Fort, Thrissur-680004 Thrissur KERALA	9846076006 drppmohanan@gmail.com
Dr Niraj Raghani	Zenith Heart And Multi-speciality Hospital	Amravati ,Walcut Compound, Amravati, Maharashtra 444603 Amravati MAHARASHTRA	7774055140 drnirajraghani@yahoo.com

Details of Ethics Committee
Modification(s)

No of Ethics Committees= 8
Name of Committee	Approval Status
Healthcare Ethics Committee	Approved
Healthcare Ethics Committee	Approved
Healthcare Ethics Committee	Approved
Healthcare Ethics Committee	Approved
Healthcare Ethics Committee	Approved
Healthcare Ethics Committee	Approved
Healthcare Ethics Committee	Approved
Institutional Ethics Committee Lisie Hospital, Kochi	Approved

Regulatory Clearance Status from DCGI

Status

Not Applicable

Health Condition / Problems Studied

Health Type	Condition
Patients	(1) ICD-10 Condition: I509\|\|Heart failure, unspecified,

Intervention / Comparator Agent

Type	Name	Details
Intervention	Nil	Nil
Comparator Agent	Nil	Nil

Inclusion Criteria

Age From	30.00 Year(s)
Age To	99.00 Year(s)
Gender	Both
Details	Patients satisfying all the following criteria will be included in the study: Male or female patients aged greater than equal to 30 years at the time of screening. Presence or known case of at least one of the following risk factors associated with early or preclinical heart failure: Hypertension Diabetes Mellitus Ischemic Heart Disease (IHD) / Coronary Artery Disease(CAD) Chronic Kidney Disease (CKD) Atrial Fibrillation Chronic Obstructive Pulmonary Disease (COPD) Obesity / Obstructive Sleep Apnoea Cardiomyopathy Hyperthyroidism History of Oncotherapy (chemotherapy or radiotherapy) Structural Heart Disease (e.g., left ventricular hypertrophy, valvular abnormalities) Willing and able to provide informed consent and comply with study procedures.

ExclusionCriteria

Details

Patients satisfying any of the following criteria will be excluded from the study:
Confirmed diagnosis of heart failure (Stage C or D) as per 2022 AHA/ACC/HFSA classification, recorded at any time prior to the index date.
Acute Coronary Syndrome (ACS) within 1 month prior to screening.
Hospitalization or major surgical procedure within the past 1 month.

Method of Generating Random Sequence

Not Applicable

Method of Concealment

Not Applicable

Blinding/Masking

Not Applicable

Primary Outcome

Outcome	TimePoints
Proportion of patients with heart failure based on the age stratified cut-off for NT-proBNP levels for diagnosis of Heart Failure (HF).	Baseline

Secondary Outcome

Outcome	TimePoints
Proportion of patients with heart stress based on the age stratified cut-off for NT-proBNP levels.	Baseline
Incidence of heart failure related composite outcomes over 3 months [Defined as occurrence of visit to Emergency Department (ED), hospitalization for heart failure (HHF) & all-cause mortality].	3 months
Evaluate management practice & drug utilization pattern in the study population.	3 months
Exploratory Endpoints: Proportion of patients with heart failure based on the various cut-offs [such as Gender, renal dysfunction(eGFR), atrial fibrillation or flutter including ventricular rate, body mass index (BMI) & other clinically relevant factors affecting NTproBNP values] for NT-proBNP levels for diagnosis of Heart Failure (HF).	Baseline
Incidence of extended composite endpoint over 3 months (defined as occurrence of Urgent Outpatient Visits, visit to Emergency Department (ED), hospitalization for heart failure (HHF), Myocardial infarction, stroke & all-cause mortality).	3 months
To evaluate the association between baseline biomarker levels & the incidence of HF related composite outcomes	3 months

Target Sample Size

Total Sample Size="2000"
Sample Size from India="2000"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials"

Phase of Trial

N/A

Date of First Enrollment (India)

19/01/2026

Date of Study Completion (India)

Applicable only for Completed/Terminated trials

Date of First Enrollment (Global)

Date Missing

Date of Study Completion (Global)

Applicable only for Completed/Terminated trials

Estimated Duration of Trial

Years="1"
Months="0"
Days="0"

Recruitment Status of Trial (Global)

Not Applicable

Recruitment Status of Trial (India)

Open to Recruitment

Publication Details

N/A

Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?

Response - NO

Brief Summary

Heart failure (HF) is a significant global public health challenge, with an estimated prevalence of over 64 million people worldwide. The estimated prevalence and incidence rates of heart failure in India due to coronary heart disease, hypertension, obesity, diabetes and rheumatic heart disease ranges from 1.3 to 4.6 million, with an annual incidence of 491, 600–1.8 million. The global burden of HF cases worldwide almost doubled from 33.5 million in 1990 to 64.3 million in 2017, while the age-standardized prevalence rate of HF showed a slow downward trend, indicating that population ageing and growth mostly accounted for the absolute increase in the number of HF cases.

SECURE-HF is a multicenter, prospective, observational study which will be conducted at multiple centres across India. The study is designed to estimate the prevalence of heart failure (HF) and “heart stress” in a high-risk outpatient population using age stratified NT-proBNP thresholds recommended by the Heart Failure Association (HFA) of the European Society of Cardiology.