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CTRI Number  CTRI/2026/02/103271 [Registered on: 09/02/2026] Trial Registered Prospectively
Last Modified On: 07/02/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   Effect of Mobilization on gait and function in athletes with chronic ankle instability 
Scientific Title of Study   Effect of Mobilization with Movement on gait and function in athletes with chronic ankle instability- A Randomized Controlled Trial 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Suraj Kumar  
Designation  Professor 
Affiliation  Jamia Millia Islamia 
Address  Room no 302, 3rd floor, department of Physiotherapy, Gate no 8, Jamia Millia Islamia

South
DELHI
110025
India 
Phone  7830337168  
Fax    
Email  skumar2@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Kulsum Akhtar 
Designation  MPT Student 
Affiliation  Jamia Millia Islamia 
Address  96-A (2nd floor), Gali number 16, Bharat Nagar, NFC, New Delhi 110025

South
DELHI
110025
India 
Phone  9911100786  
Fax    
Email  20kulsumakhtar@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Kulsum Akhtar 
Designation  MPT Student 
Affiliation  Jamia Millia Islamia 
Address  96-A, Gali no 16, Bharat Nagar, NFC, New Delhi 110025

South
DELHI
110025
India 
Phone  9911100786  
Fax    
Email  20kulsumakhtar@gmail.com  
 
Source of Monetary or Material Support  
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia University (A Central University) New Delhi-110025, India  
 
Primary Sponsor  
Name  Jamia Millia Islamia A Central University 
Address  Jamia Nagar, New Delhi 110025, India  
Type of Sponsor  Research institution 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Suraj Kumar  Jamia Millia Islamia  Jamia Nagar, New Delhi
South
DELHI 
7830337168

skumar2@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
INSTITUTIONAL ETHICS COMMITTEE, JAMIA MILLIA ISLAMIA  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  Athletes with chronic ankle instability 
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Mobilization With Movement  Mobilization With Movement along with strength training as conventional training 
Comparator Agent  strength training as conventional training  Mobilzation With Movement along with strength training as conventional training 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  30.00 Year(s)
Gender  Male 
Details  Athletes aged between 18 to 30 years
Working language of English
History of at least 1 significant ankle sprain
Cumberland Ankle Instability Tool less than 24
Foot and Ankle Ability Measure ADL scale less than 90 percent, Sport scale less than 80 percent
 
 
ExclusionCriteria 
Details  History of previous surgeries to the musculoskeletal structures (i.e., bones, joint structures, nerves) in either limb of the lower extremity
History of a fracture in either limb of the lower extremity requiring realignment
Acute injury to musculoskeletal structures of other joints of the lower extremity in the previous 3 months, which impacted joint integrity and function
Bilateral chronic ankle instability
 
 
Method of Generating Random Sequence   Other 
Method of Concealment   Other 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
Gait  Baseline and 6 week 
 
Secondary Outcome  
Outcome  TimePoints 
function  Day 1 and 6th week 
 
Target Sample Size   Total Sample Size="48"
Sample Size from India="48" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   18/02/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Ankle sprain is the most common sport-related injury (Fong et al., 2007). The International Ankle Consortium defines the pathology of residual symptoms after a significant ankle sprain as chronic ankle instability (CAI). The International Ankle Consortium characterized CAI as a condition in which an individual has a significant ankle sprain and/or experienced recurrent ankle sprain on the sprained ankle, and/or feels ankle instability, and/or experienced giving way at least twice in the past 6 months (Gribble et al., 2014).

Ankle sprains account for about 16-40% of sports related injuries (Jungmann et al., 2023). The prevalence of CAI among athletes is 23.4% (Tanen et al., 2014). According to Roos et al. (2017), noncontact, player contact, or surface touch may be the most frequent mechanism of injury resulting in inversion ankle sprain. This could result in internal rotation, ankle plantar flexion, and subtalar inversion, all of which would put undue strain on the lateral ankle ligament complex. Ankle sprain discomfort and incapacity may be caused by fibula malpositioning, which has been observed in injured ankles (Fukuhara et al., 2012; Hubbard & Hertel, 2008), rather than injury to the anterior talofibular ligament itself (Mulligan, 2010). The CAI group exhibited dorsiflexion deficits (Inje et al., 2022). A reduction in posterior glide of the talus in the ankle mortise in subjects was observed 6 months following ankle sprain (Denegar et al., 2002). Athletes with unilateral CAI reported significantly lower ankle function in the Foot and Ankle Ability Measure (FAAM), when compared with controls (Donovan et al., 2020).

Symptoms of CAI are not limited to pain, swelling, the feeling of giving way, and limited range of motion (ROM) (Kosik et al., 2019). Gait alterations have been documented in CAI, and most of the studied parameters were spatiotemporal ones. Step length, cadence, walking speed, and single limb duration were reduced in those with CAI, while their base of support was larger. Patients with CAI were found to walk with approximately 16% slower walking velocity, 9% lower cadence, and approximately 7% lower step length. Furthermore, the base of support during walking in the CAI group was approximately 43% wider, and the single limb support phase was 3.5% shorter compared to the control group (Gigi et al., 2015). In order to decrease discomfort and improve joint range of motion (ROM), management includes exercise therapy that emphasizes neuromuscular and proprioceptive training in addition to joint mobilization (Doherty et al., 2014).

One of the most recent ideas in active joint mobilization is mobilization with movement (MWM). The patient actively moves in the direction of pain and movement limitation while the therapist provides a prolonged, pain-free mobilization force at the afflicted joint. The goal is to make the patient’s painfully limited movement pain free so they can participate in a gradual recovery to their regular functional activity (Hing Wayne et al., 2019).

For chronic recurring ankle sprains, Weerasekara et al. (2020) found moderate quality evidence supporting MWM in their recent systematic review. The most often studied MWM technique in the review was a posterior talar glide MWM (Weerasekara et al., 2020). Mulligan’s mobilization with movement improves dorsiflexion range of motion (DFROM) in individuals with CAI (Vallandingham et al., 2019).

Previous studies have assessed reduced function and alterations in gait parameters in subjects affected with chronic ankle instability. To the best of my knowledge, no previous study has examined gait parameter changes after giving mobilization with movement. Therefore, this study aims to bridge this gap by assessing the effect of MWM on gait and function in university athletes with chronic ankle instability.

 
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