| CTRI Number |
CTRI/2026/02/103271 [Registered on: 09/02/2026] Trial Registered Prospectively |
| Last Modified On: |
07/02/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Physiotherapy (Not Including YOGA) |
| Study Design |
Randomized, Parallel Group, Active Controlled Trial |
|
Public Title of Study
|
Effect of Mobilization on gait and function in athletes with chronic ankle instability |
|
Scientific Title of Study
|
Effect of Mobilization with Movement on gait and function in athletes with chronic ankle instability- A Randomized Controlled Trial |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr Suraj Kumar |
| Designation |
Professor |
| Affiliation |
Jamia Millia Islamia |
| Address |
Room no 302, 3rd floor, department of Physiotherapy, Gate no 8, Jamia Millia Islamia
South DELHI 110025 India |
| Phone |
7830337168 |
| Fax |
|
| Email |
skumar2@gmail.com |
|
Details of Contact Person Scientific Query
|
| Name |
Kulsum Akhtar |
| Designation |
MPT Student |
| Affiliation |
Jamia Millia Islamia |
| Address |
96-A (2nd floor), Gali number 16, Bharat Nagar, NFC, New Delhi 110025
South DELHI 110025 India |
| Phone |
9911100786 |
| Fax |
|
| Email |
20kulsumakhtar@gmail.com |
|
Details of Contact Person Public Query
|
| Name |
Kulsum Akhtar |
| Designation |
MPT Student |
| Affiliation |
Jamia Millia Islamia |
| Address |
96-A, Gali no 16, Bharat Nagar, NFC, New Delhi 110025
South DELHI 110025 India |
| Phone |
9911100786 |
| Fax |
|
| Email |
20kulsumakhtar@gmail.com |
|
|
Source of Monetary or Material Support
|
| Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia University (A Central University) New Delhi-110025, India |
|
|
Primary Sponsor
|
| Name |
Jamia Millia Islamia A Central University |
| Address |
Jamia Nagar, New Delhi 110025, India |
| Type of Sponsor |
Research institution |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Suraj Kumar |
Jamia Millia Islamia |
Jamia Nagar, New Delhi South DELHI |
7830337168
skumar2@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| INSTITUTIONAL ETHICS COMMITTEE, JAMIA MILLIA ISLAMIA |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Healthy Human Volunteers |
Athletes with chronic ankle instability |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Mobilization With Movement |
Mobilization With Movement along with strength training as conventional training |
| Comparator Agent |
strength training as conventional training |
Mobilzation With Movement along with strength training as conventional training |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
30.00 Year(s) |
| Gender |
Male |
| Details |
Athletes aged between 18 to 30 years
Working language of English
History of at least 1 significant ankle sprain
Cumberland Ankle Instability Tool less than 24
Foot and Ankle Ability Measure ADL scale less than 90 percent, Sport scale less than 80 percent
|
|
| ExclusionCriteria |
| Details |
History of previous surgeries to the musculoskeletal structures (i.e., bones, joint structures, nerves) in either limb of the lower extremity
History of a fracture in either limb of the lower extremity requiring realignment
Acute injury to musculoskeletal structures of other joints of the lower extremity in the previous 3 months, which impacted joint integrity and function
Bilateral chronic ankle instability
|
|
|
Method of Generating Random Sequence
|
Other |
|
Method of Concealment
|
Other |
|
Blinding/Masking
|
Participant Blinded |
|
Primary Outcome
|
| Outcome |
TimePoints |
| Gait |
Baseline and 6 week |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| function |
Day 1 and 6th week |
|
|
Target Sample Size
|
Total Sample Size="48" Sample Size from India="48"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
18/02/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0" Months="6" Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Ankle
sprain is the most common sport-related injury (Fong et al., 2007). The
International Ankle Consortium defines the pathology of residual symptoms after
a significant ankle sprain as chronic ankle instability (CAI). The
International Ankle Consortium characterized CAI as a condition in which an
individual has a significant ankle sprain and/or experienced recurrent ankle
sprain on the sprained ankle, and/or feels ankle instability, and/or
experienced giving way at least twice in the past 6 months (Gribble et al., 2014).
Ankle sprains account for about 16-40% of sports related
injuries (Jungmann et al., 2023). The prevalence of CAI among athletes is 23.4%
(Tanen et al., 2014). According to Roos et al. (2017), noncontact, player
contact, or surface touch may be the most frequent mechanism of injury
resulting in inversion ankle sprain. This could result in internal rotation,
ankle plantar flexion, and subtalar inversion, all of which would put undue
strain on the lateral ankle ligament complex. Ankle sprain discomfort and
incapacity may be caused by fibula malpositioning, which has been observed in
injured ankles (Fukuhara et al., 2012; Hubbard & Hertel, 2008), rather than
injury to the anterior talofibular ligament itself (Mulligan, 2010). The CAI
group exhibited dorsiflexion deficits (Inje et al., 2022). A reduction in
posterior glide of the talus in the ankle mortise in subjects was observed 6
months following ankle sprain (Denegar et al., 2002). Athletes with unilateral
CAI reported significantly lower ankle function in the Foot and Ankle Ability
Measure (FAAM), when compared with controls (Donovan et al., 2020).
Symptoms of CAI are not limited to pain, swelling, the
feeling of giving way, and limited range of motion (ROM) (Kosik et al., 2019).
Gait alterations have been documented in CAI, and most of the studied
parameters were spatiotemporal ones. Step length, cadence, walking speed, and
single limb duration were reduced in those with CAI, while their base of
support was larger. Patients with CAI were found to walk with approximately 16%
slower walking velocity, 9% lower cadence, and approximately 7% lower step
length. Furthermore, the base of support during walking in the CAI group was
approximately 43% wider, and the single limb support phase was 3.5% shorter compared
to the control group (Gigi et al., 2015). In order to decrease discomfort and
improve joint range of motion (ROM), management includes exercise therapy that
emphasizes neuromuscular and proprioceptive training in addition to joint
mobilization (Doherty et al., 2014).
One of the most recent ideas in active joint mobilization is
mobilization with movement (MWM). The patient actively moves in the direction
of pain and movement limitation while the therapist provides a prolonged,
pain-free mobilization force at the afflicted joint. The goal is to make the
patient’s painfully limited movement pain free so they can participate in a
gradual recovery to their regular functional activity (Hing Wayne et al.,
2019).
For chronic recurring ankle sprains, Weerasekara et al.
(2020) found moderate quality evidence supporting MWM in their recent
systematic review. The most often studied MWM technique in the review was a
posterior talar glide MWM (Weerasekara et al., 2020). Mulligan’s mobilization
with movement improves dorsiflexion range of motion (DFROM) in individuals with
CAI (Vallandingham et al., 2019).
Previous studies have assessed reduced function and
alterations in gait parameters in subjects affected with chronic ankle
instability. To the best of my knowledge, no previous study has examined gait parameter
changes after giving mobilization with movement. Therefore, this study aims to
bridge this gap by assessing the effect of MWM on gait and function in
university athletes with chronic ankle instability. |