| CTRI Number |
CTRI/2026/01/102325 [Registered on: 28/01/2026] Trial Registered Prospectively |
| Last Modified On: |
22/01/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Homeopathy |
| Study Design |
Single Arm Study |
|
Public Title of Study
|
Role of Individualized Homoeopathic Medicine in the Treatment of Varicose Vein |
|
Scientific Title of Study
|
ASSESSING THE MIASM AND EFFECTIVENESS OF INDIVIDUALIZED HOMOEOPATHIC MEDICINE IN THE MANAGEMENT OF VARICOSE VEIN - A QUASI EXPERIMENTAL STUDY |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
DR AISHWARYA |
| Designation |
PG scholar |
| Affiliation |
Indian |
| Address |
Government Homoeopathic Medical College and hospital DR Siddhaih Puranik road basaveshwara Nagar bangalore
Department of Organon of medicine first floor room number 53 NIL Bangalore KARNATAKA 560079 India |
| Phone |
8073947708 |
| Fax |
|
| Email |
aish71404@gmail.com |
|
Details of Contact Person Scientific Query
|
| Name |
Dr Vijayalakshmi M Angadi |
| Designation |
Professor |
| Affiliation |
Indian |
| Address |
Government Homoeopathic Medical College and hospital DR Siddhaih Puranik road basaveshwara Nagar bangalore
Department of Organon of medicine first floor room number 53 NIL Bangalore KARNATAKA 560079 India |
| Phone |
9448989575 |
| Fax |
|
| Email |
drvijayalaxmi.angadi@gmail.com |
|
Details of Contact Person Public Query
|
| Name |
DR AISHWARYA |
| Designation |
PG scholar |
| Affiliation |
Indian |
| Address |
Government Homoeopathic Medical College and hospital DR Siddhaih Puranik road basaveshwara Nagar bangalore
Department of Organon of medicine first floor room number 53 NIL Bangalore KARNATAKA 560079 India |
| Phone |
8073947708 |
| Fax |
|
| Email |
aish71404@gmail.com |
|
|
Source of Monetary or Material Support
|
|
|
Primary Sponsor
|
| Name |
Government Homoeopathic Medical College and hospital bangalore |
| Address |
Government Homoeopathic Medical College and hospital DR Siddhaih Puranik road basaveshwara Nagar bangalore
Department of Organon of medicine first floor room number 53 |
| Type of Sponsor |
Research institution and hospital |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| DR AISHWARYA |
Government Homoeopathic Medical College and hospital bangalore |
Government Homoeopathic Medical College and hospital DR Siddhaih Puranik road basaveshwara Nagar bangalore
Department of Organon of medicine first floor room number 53 Bangalore KARNATAKA |
8073947708
aish71404@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Government Homoeopathic Medical College and hospital bangalore |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: I838||Varicose veins of lower extremities with other complications, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Individualized Homoeopathic remedy |
Remedy will be prescribed after complete case taking and making totality to symptoms and repertorization and dosage will be selected upon the susceptibility of the patient and repetition is done according to Homoeopathic principles |
| Comparator Agent |
No comparator |
Nil |
|
|
Inclusion Criteria
|
| Age From |
20.00 Year(s) |
| Age To |
60.00 Year(s) |
| Gender |
Both |
| Details |
Subjects who are willing to take part in the study and sign the written informed consent form.
Subjects of age group from 20-60 years.
Newly Diagnosed case of varicose veins of lower limb belonging to C2 categories of CEAP classification. |
|
| ExclusionCriteria |
| Details |
• Subjects with complications of Varicose vein thrombophlebitis , deep vein thrombosis , varicose ulcer.
Subjects taking medicines from other systems of medicine for the same complaints.
Pregnant women and lactating mothers.
Subjects having under lying disease like uncontrolled diabetes, Cardiovascular disorders,Coagulation disorders. |
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
| When the revised venous clinical severity score represents zero and no signs and symptoms present. |
For first 3 months for every 15 days and for next 3 months once in a month follow up will be done. |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| when the venous clinical severity score represents reduction in score from base line 50%, with presence of few signs and symptoms. |
For first 3 months for every 15 days and for next 3 months once in a month follow up will be done. |
|
|
Target Sample Size
|
Total Sample Size="55" Sample Size from India="55"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
11/02/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1" Months="6" Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Varicose veins are enlarged, twisted, and abnormally dilated superficial veins, most commonly found in the legs.1
Varicose veins (VV) are a widespread concern, particularly among older adults, and can lead to physical disfigurement, functional limitations, and a reduced overall quality of life
According to a study Globally, varicose veins affect about 10-20% of people , but in India, the prevalence is considerably lower at approximately 5%. Homoeopathy takes a holistic approach to healing, focusing not only on the disease but the individual as a whole. This system of medicine aims to go beyond merely suppressing symptoms—it strives to enhance overall well-being and improve quality of life on a deeper level. When it comes to managing varicose veins, homoeopathic remedies offer a gentle and effective option. These medicines work to ease venous congestion and assist in controlling the associated symptoms, such as leg pain, a sensation of heaviness, cramps, itching, and swelling.
Aesculus hippocastanum ( Horse chestnut seed extract) has shown results in reducing symptoms of venous insufficiency – particularly leg pain, edema, and heaviness – through its venotonic and anti-inflammatory effects. The active compound, aescin, strengthens vein wall, improves venous tone.
However, despite encouraging preliminary evidence, the use of Aesculus hippocastanum remains under- researched in many regions, and standardized clinical trials are limited. There is a need to explore its efficacy, safety, and potential role as an adjunct or alternative therapy in the management of varicose veins.
Hence, this study is intend to assess and compare the effectiveness of constitutional homoeopathic medicine with Aesculus hippocastanum in the management of varicose vein. The analysis of the efficacy will be done using the revised venous clinical severity scoring scale (RVCSS).
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