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CTRI Number  CTRI/2026/01/102325 [Registered on: 28/01/2026] Trial Registered Prospectively
Last Modified On: 22/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Single Arm Study 
Public Title of Study   Role of Individualized Homoeopathic Medicine in the Treatment of Varicose Vein  
Scientific Title of Study   ASSESSING THE MIASM AND EFFECTIVENESS OF INDIVIDUALIZED HOMOEOPATHIC MEDICINE IN THE MANAGEMENT OF VARICOSE VEIN - A QUASI EXPERIMENTAL STUDY 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  DR AISHWARYA  
Designation  PG scholar  
Affiliation  Indian 
Address  Government Homoeopathic Medical College and hospital DR Siddhaih Puranik road basaveshwara Nagar bangalore Department of Organon of medicine first floor room number 53
NIL
Bangalore
KARNATAKA
560079
India 
Phone  8073947708  
Fax    
Email  aish71404@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Vijayalakshmi M Angadi 
Designation  Professor  
Affiliation  Indian 
Address  Government Homoeopathic Medical College and hospital DR Siddhaih Puranik road basaveshwara Nagar bangalore Department of Organon of medicine first floor room number 53
NIL
Bangalore
KARNATAKA
560079
India 
Phone  9448989575  
Fax    
Email  drvijayalaxmi.angadi@gmail.com  
 
Details of Contact Person
Public Query
 
Name  DR AISHWARYA  
Designation  PG scholar  
Affiliation  Indian 
Address  Government Homoeopathic Medical College and hospital DR Siddhaih Puranik road basaveshwara Nagar bangalore Department of Organon of medicine first floor room number 53
NIL
Bangalore
KARNATAKA
560079
India 
Phone  8073947708  
Fax    
Email  aish71404@gmail.com  
 
Source of Monetary or Material Support  
NIL 
 
Primary Sponsor  
Name  Government Homoeopathic Medical College and hospital bangalore  
Address  Government Homoeopathic Medical College and hospital DR Siddhaih Puranik road basaveshwara Nagar bangalore Department of Organon of medicine first floor room number 53 
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
DR AISHWARYA   Government Homoeopathic Medical College and hospital bangalore   Government Homoeopathic Medical College and hospital DR Siddhaih Puranik road basaveshwara Nagar bangalore Department of Organon of medicine first floor room number 53
Bangalore
KARNATAKA 
8073947708

aish71404@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Government Homoeopathic Medical College and hospital bangalore   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: I838||Varicose veins of lower extremities with other complications,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Individualized Homoeopathic remedy  Remedy will be prescribed after complete case taking and making totality to symptoms and repertorization and dosage will be selected upon the susceptibility of the patient and repetition is done according to Homoeopathic principles  
Comparator Agent  No comparator   Nil 
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  Subjects who are willing to take part in the study and sign the written informed consent form.
Subjects of age group from 20-60 years.
Newly Diagnosed case of varicose veins of lower limb belonging to C2 categories of CEAP classification. 
 
ExclusionCriteria 
Details  • Subjects with complications of Varicose vein thrombophlebitis , deep vein thrombosis , varicose ulcer.
Subjects taking medicines from other systems of medicine for the same complaints.
Pregnant women and lactating mothers.
Subjects having under lying disease like uncontrolled diabetes, Cardiovascular disorders,Coagulation disorders. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
When the revised venous clinical severity score represents zero and no signs and symptoms present.  For first 3 months for every 15 days and for next 3 months once in a month follow up will be done. 
 
Secondary Outcome  
Outcome  TimePoints 
when the venous clinical severity score represents reduction in score from base line 50%, with presence of few signs and symptoms.  For first 3 months for every 15 days and for next 3 months once in a month follow up will be done. 
 
Target Sample Size   Total Sample Size="55"
Sample Size from India="55" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   11/02/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   Varicose veins are enlarged, twisted, and abnormally dilated superficial veins, most commonly found in the legs.1
Varicose veins (VV) are a widespread concern, particularly among older adults, and can lead to physical disfigurement, functional limitations, and a reduced overall quality of life
According to a study Globally, varicose veins affect about 10-20% of people , but in India, the prevalence is considerably lower at approximately 5%.
Homoeopathy takes a holistic approach to healing, focusing not only on the disease but the individual as a whole. This system of medicine aims to go beyond merely suppressing symptoms—it strives to enhance overall well-being and improve quality of life on a deeper level.
When it comes to managing varicose veins, homoeopathic remedies offer a gentle and effective option. These medicines work to ease venous congestion and assist in controlling the associated symptoms, such as leg pain, a sensation of heaviness, cramps, itching, and swelling.
Aesculus hippocastanum ( Horse chestnut seed extract) has shown results in reducing symptoms of venous insufficiency – particularly leg pain, edema, and heaviness – through its venotonic and anti-inflammatory effects. The active compound, aescin, strengthens vein wall, improves venous tone.
However, despite encouraging preliminary evidence, the use of Aesculus hippocastanum remains under- researched in many regions, and standardized clinical trials are limited. There is a need to explore its efficacy, safety, and potential role as an adjunct or alternative therapy in the management of varicose veins.
Hence, this study is intend to assess and compare the effectiveness of constitutional homoeopathic medicine with Aesculus hippocastanum in the management of varicose vein. The analysis of the efficacy will be done using the revised venous clinical severity scoring scale (RVCSS).
 
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