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CTRI Number  CTRI/2025/11/098220 [Registered on: 28/11/2025] Trial Registered Prospectively
Last Modified On: 27/11/2025
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Radiation Therapy 
Study Design  Single Arm Study 
Public Title of Study   A prospective study of use of Low Dose Radiation Therapy for pain relief in patients with osteoarthritis of hands which is not controlled by routine medications 
Scientific Title of Study   A Prospective Study of Low Dose Radiation Therapy in Osteoarthritis of Hands 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Mayur Mayank 
Designation  Senior Consultant 
Affiliation  Medanta The Medicity 
Address  Division of Radiation Oncology, Medanta Cancer Institute, Medanta The Medicity, Sector 38, Gurugram

Gurgaon
HARYANA
122001
India 
Phone  9560250562  
Fax    
Email  mayank.rch@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Mayur Mayank 
Designation  Senior Consultant 
Affiliation  Medanta The Medicity 
Address  Division of Radiation Oncology, Medanta Cancer Institute, Medanta The Medicity, Sector 38, Gurugram


HARYANA
122001
India 
Phone  9560250562  
Fax    
Email  mayank.rch@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Mayur Mayank 
Designation  Senior Consultant 
Affiliation  Medanta The Medicity 
Address  Division of Radiation Oncology, Medanta Cancer Institute, Medanta The Medicity, Sector 38, Gurugram


HARYANA
122001
India 
Phone  9560250562  
Fax    
Email  mayank.rch@gmail.com  
 
Source of Monetary or Material Support  
Nil 
 
Primary Sponsor  
Name  Medanta The Medicity 
Address  Sector 38, Gurugram, Haryana 
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Mayur Mayank  Medanta The Medicity  Division of Radiation Oncology Medanta Cancer Institute Medanta The Medicity Sector 38
Gurgaon
HARYANA 
9560250562

mayank.rch@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Medanta Institutional Ethics Committee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M190||Primary osteoarthritis of other joints,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Low Dose Radiation Therapy  Low Dose Radiation Therapy (300 cGy in 6 fractions over 3 weeks (50 cGy/fraction delivered twice weekly) for pain control in Osteoarthritis of Hands 
Comparator Agent  Nil  Nil 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  99.00 Year(s)
Gender  Both 
Details  - Diagnosed to have Osteoarthritis of the hands
- Patients refractory to conventional NSAIDs to full tolerance dose
- Patients needing more than two NSAIDs
- Patients consenting to be a part of the study 
 
ExclusionCriteria 
Details  - Patients with diagnosis other than Osteoarthritis
- Patients who have received Radiation Therapy to the affected area earlier due to any reason
- Patients not consenting to be a part of the study. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
The reduction in the pain score of the patients with Osteoarthritis of the hands after low dose Radiation Therapy  3 & 6 months after the completion of Low Dose Radiation Therapy and then 6 monthly thereafter 
 
Secondary Outcome  
Outcome  TimePoints 
The reduction in use of NSAIDs in patients with Osteoarthritis of the hands after low dose Radiation Therapy  3 & 6 months after the completion of Low Dose Radiation Therapy and then 6 monthly thereafter 
Radiographic changes observed in the Hands in patients with Osteoarthritis after low dose Radiation Therapy  3 & 6 months after the completion of Low Dose Radiation Therapy and then 6 monthly thereafter 
 
Target Sample Size   Total Sample Size="50"
Sample Size from India="50" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 2 
Date of First Enrollment (India)   15/12/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="11"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Osteoarthritis (OA) is the most common form of arthritis in the world. In India, around 23.46 million individuals had OA in 1990 which increased to 62.35 million in 2019. OA was the 20th most common cause disability in India in 2019, increasing from 23rd most common cause in 1990. Knee OA is the most common form of OA in India, followed by hand OA. Radiation therapy (RT) has been used to treat benign conditions for over a century. Conventional and hypofractionated RT have anti-proliferative principles that are used in the treatment of malignant disorders. Alternatively, at doses of less than 1 Gray (Gy) per fraction, RT has been shown to have strong anti-inflammatory effects. By using anti-inflammatory properties, low dose radiation therapy (LDRT) has been used to successfully treat painful musculoskeletal conditions such as plantar fasciitis, trochanteric bursitis, medial and lateral epicondylitis, tendinopathies of various joints, and osteoarthritis (OA) of both large and small joints have been shown to benefit from LDRT. This study will try to assess the role of Low Dose Radiation Therapy for pain management in patients with OA of the hands which is refractory to pain medications and/or needs too many pain medications for management.
 
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