This interventional study aims to evaluate the effectiveness of individualized homoeopathic treatment in managing menstrual dysfunction among women with primary hypothyroidism. Menstrual irregularities assessed include amenorrhea, oligomenorrhoea, menorrhagia, metrorrhagia, and epimenorrhea. The study further examines changes in serum follicle-stimulating hormone  and luteinizing hormone  levels as objective biomarkers of hypothalamic pituitary ovarian  axis regulation under homoeopathic therapy.

Pre and post treatment variations in thyroid profile parameters, including TSH T3 and T4 will also be analyzed to determine any associated improvement in endocrine function. Additionally  the study explores the correlation between biochemical normalization and clinical improvement in menstrual patterns.

Due to the absence of prior interventional evidence in this area, the study proposes an initial sample size of 34 participants.

Inclusion criteria comprise women aged 18 to 45 years with biochemically confirmed primary hypothyroidism, stable on thyroxine therapy for more than 3 months, presenting with menstrual dysfunction and documented FSH and LH alterations measured between cycle days 2 to 5. Participants must provide voluntary written informed consent. Exclusion criteria include pregnancy or lactation, recent use of hormonal contraceptives, systemic or psychiatric illnesses substance abuse and known cases of PCOS with hyperandrogenism endometriosis dysfunctional uterine bleeding pelvic inflammatory disease bleeding disorders  or structural uterine anomalies.