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CTRI Number  CTRI/2025/12/098607 [Registered on: 08/12/2025] Trial Registered Prospectively
Last Modified On: 05/12/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Non-randomized, Active Controlled Trial 
Public Title of Study   The study is about to see the effect of neural Mobilization and the proprioceptive Neuromuscular fascilitation on Cervicogenic headache  
Scientific Title of Study   Neural Mobilization vs Proprioceptive Neuromuscular Facilitation :A Comparative Approach To Cervicogenic Headache 
Trial Acronym  Neural Mobilization Propriceptive neuromucular facilitation  
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Sunita Mardi 
Designation  PG Student  
Affiliation  Amity Institute Of Health And Allied Science  
Address  Room NO.5 Lower Ground Floor F1 Block Department Of Physiotherapy,Amity Institute Of Health And Allied Science
NA
Gautam Buddha Nagar
UTTAR PRADESH
201303
India 
Phone  8210057702  
Fax  NA  
Email  mardisunita18@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Ruchika Kalra PT 
Designation  Teaching Associate  
Affiliation  Amity Institute Of Health And Allied Science  
Address  Room no 5 Lower ground F1 block Department of Physiotherapy Amity Institute of Health Allied Sciences Amity University

Gautam Buddha Nagar
UTTAR PRADESH
201313
India 
Phone  9718417185  
Fax    
Email  rkalra1@amity.edu  
 
Details of Contact Person
Public Query
 
Name  Dr Vidhi Jain PT 
Designation  Senior Physiotherapist 
Affiliation  Vinayak Hospital  
Address  Department of physiotherapy vinayak Hospital


UTTAR PRADESH
201301
India 
Phone  9582437144  
Fax    
Email  vidhij.physio@gmail.com  
 
Source of Monetary or Material Support  
Amity institute of health and allied science SECTOR 125 NOIDA Uttar Pradesh PINCODE 201313  
 
Primary Sponsor  
Name  NA 
Address  NA 
Type of Sponsor  Other [NA] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Sunita Mardi  VINAYAK HOSPITAL   ROOM No 6 Department of physiotherapy
Gautam Buddha Nagar
UTTAR PRADESH 
8210057702

mardisunita18@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 2  
Name of Committee  Approval Status 
NTCC  Approved 
NTCC   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: G448||Other specified headache syndromes,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Group A Proprioceptive Neuromuscular Facilitation -Assisted soft Tissue Mobilization and TENS Group B- Neural Tissue Mobilization Mobilization and TENS  Group A: PNF + IASTM + TENS Participants received: TENS for 10 minutes daily (100 Hz, prevertebral and suboccipital placement). IASTM for 5 minutes on SCM, upper trapezius, and suboccipital muscles. PNF Hold–Relax techniques for all cervical motions (flexion, extension, lateral flexion, rotation), performed for 5–10 sec holds, 5 repetitions × 2 sets, 3 times per week for 4 weeks. Group B: Neural Mobilization + IASTM + TENS Participants received: TENS for 10 minutes daily (same parameters as Group A). IASTM for 5 minutes on SCM, upper trapezius, and suboccipital muscles. Neural Tissue Mobilization for the occipital nerve: upper cervical flexion with lateral flexion away from the affected side, 2 repetitions of 20 oscillations, performed 5 days per week for 10 sessions.  
Comparator Agent  NA  NA 
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  59.00 Year(s)
Gender  Both 
Details  Age between 20-59 yrs
Patient with chronic pain with frequent cervicogenic headache according to the classification of ICHD-3
Both Females and males 
 
ExclusionCriteria 
Details  Previous Fracture of history cervical spine
Subject having other than cervicogenic headache
Disc Prolaps
TMJ Dysfunction,subject with any tumour,other Surgeries
Patient have Cervical flexion rotation Test 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Neck Disability Index
NPRS
Headache. Impact scale 
Neck disability scale for 4 weeks
NPRS For 4 Weeks
Headache impact scale for 4 weeks
Headache impact scale for 4 weeks 
 
Secondary Outcome  
Outcome  TimePoints 
NA  NA 
 
Target Sample Size   Total Sample Size="53"
Sample Size from India="53" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   17/12/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="3"
Days="5" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   Overview

Cervicogenic headache (CGH) is a secondary headache arising from dysfunction in the cervical spine, particularly the C1–C2 segments, soft tissues, or neural structures. It typically presents as unilateral, non-throbbing neck-related pain that worsens with cervical movement or poor posture. Because physiotherapy plays a significant role in restoring cervical mobility and reducing neuro-musculoskeletal irritation, this study compares two effective techniques: Neural Mobilization and PNF, each combined with IASTM
2. Rationale
Existing research supports the effectiveness of PNF, neural mobilization, and IASTM individually, but limited comparative data exists on their combined effect in CGH. This study addresses this gap by evaluating which intervention more effectively reduces pain and disability.
3. Aim and Objectives
Aim
To evaluate and compare the effects of:
Neural Mobilization + IASTM
versus
PNF + IASTM
on reducing pain and disability in individuals with cervicogenic headache.
Objectives
To measure improvements in pain and functional disability following Neural Mobilization + IASTM.
To measure improvements following PNF + IASTM.
To compare the effectiveness of both approaches.
4. Hypotheses
Null Hypothesis: No significant difference exists between the two treatment methods.
Alternative Hypothesis: A significant difference exists in treatment outcomes between the two methods.
5. Literature Highlights
PNF techniques (especially hold–relax) effectively reduce pain and disability in CGH, particularly among sedentary individuals.
IASTM shows strong evidence for decreasing myofascial tightness and improving mobility in suboccipital and cervical regions.
Neural tissue mobilization improves nerve mobility but may be less effective than certain soft tissue–focused techniques in some cases.
Outcome measures such as the Neck Disability Index (NDI) and Numeric Pain Rating Scale (NPRS) are reliable and widely validated in CGH research.
Cervical Flexion–Rotation Test demonstrates high diagnostic accuracy for CGH.

6. Methodology
Design: Experimental
Sample: 53 participants (aged 20–59 years) diagnosed with CGH according to ICHD-3 criteria.
Sampling: Convenient sampling, Delhi
Outcome Measures: NPRS, NDI, HIT
Intervention Tools: TENS, IASTM instruments
Inclusion Criteria
Ages 20–59
Chronic neck pain with recurrent CGH
Both sexes
Exclusion Criteria
Cervical fractures
TMJ dysfunction
Disc prolapse
Tumors or operative history
Non-CGH headaches
7. Intervention Protocol
Group A (PNF + IASTM + TENS)
TENS: 10 minutes daily
IASTM: 5 minutes on SCM, trapezius, suboccipitals
PNF Hold–Relax: All cervical motions; 5–10 sec holds; 5 reps × 2 sets; 3/week for 4 weeks
Group B (Neural Mobilization + IASTM + TENS)
TENS: Same as Group A
IASTM: Same as Group A
Neural Mobilization: Upper cervical flexion with lateral flexion; 2 reps × 20 oscillations; 5 days/week for 10 sessions
8. Expected Clinical Outcome
Both interventions are expected to reduce:
Pain (NPRS)

Functional disability (NDI)

Headache-related impact (HIT)


Comparative results will determine which technique offers superior clinical benefits for CGH.


 
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