1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   
   
3. Who will be able to view these files?
   Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [auqib44@gmail.com].
   


6. For how long will this data be available start date provided 12-09-2026 and end date provided 11-11-2035?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - nil

Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by joint inflammation, systemic complications, and increased morbidity and mortality. Growing evidence shows that RA patients often have autonomic nervous system imbalance, especially reduced parasympathetic activity and low heart rate variability (HRV), both linked to higher cardiovascular risk. Inflammation and autonomic dysfunction appear to interact through elevated cytokines and impaired vagal regulation. The vagus nerve plays a key anti-inflammatory role via the cholinergic anti-inflammatory pathway. Because of this, non-invasive methods that enhance vagal activity—such as deep breathing, yoga, and meditation—are being explored as adjunct therapies. Guided deep breathing, in particular, improves vagal tone and HRV through baroreflex activation and may help modulate inflammation and disease activity in RA.