Tooth extraction is frequently followed by significant bone loss, resulting in reduced alveolar ridge height and width that can compromise subsequent implant placement and aesthetics. Alveolar ridge preservation techniques aim to minimize this bone resorption using bone grafts and adjunctive agents. Demineralized Freeze-Dried Bone Allograft also known as DFDBA is a well documented allograft material for socket preservation due to its osteoinductive potential.

Vitamin D3 plays a crucial role in calcium metabolism and bone remodeling by promoting osteoblastic activity and mineralization. Its topical incorporation into bone grafts may enhance graft integration and new bone formation.

This randomized controlled clinical trial aims to compare the efficacy of DFDBA alone and DFDBA enriched with Vitamin D3 gel in post-extraction alveolar socket preservation. Sixty patients requiring extraction of a single tooth preferably premolar or molar and subsequent implant placement will be recruited and randomly assigned into two groups:

Group I: Socket preservation using DFDBA alone

Group II: Socket preservation using DFDBA enriched with Vitamin D3 gel

Clinical evaluation for assessing soft tissue healing, radiographic assessment for ridge height and width using RVG and CBCT, and histologic analysis for vital bone formation, residual graft, connective tissue content will be performed at baseline and after 6 months.

The study is expected to determine whether Vitamin D3 supplementation enhances the regenerative potential of DFDBA, resulting in improved bone quality and quantity for future implant placement.

Study Design: Double-blinded, randomized controlled clinical trial
Study Duration: 18 months
Sample Size: 60 participants
Study Site: Ranjeet Deshmukh Dental College and Research Centre, Nagpur