| CTRI Number |
CTRI/2025/11/098159 [Registered on: 27/11/2025] Trial Registered Prospectively |
| Last Modified On: |
26/11/2025 |
| Post Graduate Thesis |
No |
| Type of Trial |
Observational |
|
Type of Study
|
Cross Sectional Study |
| Study Design |
Single Arm Study |
|
Public Title of Study
|
Studying chest and heart measurements using CT scans to find the best spot and depth for effective heart compressions during cardiac care |
|
Scientific Title of Study
|
Radiological Assessment of Optimal Chest Compression Point and Achievable Compression Depth for CPR across various BMI Categories in Indian Population using CT Coronary Angiography |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Anushka Srivatsan |
| Designation |
MBBS Student-Primary Investigator |
| Affiliation |
Kasturba Medical College, Manipal |
| Address |
Kasturba Medical College, Tiger Circle Road, Madhav Nagar, Manipal, Karnataka 576104
Udupi KARNATAKA 576104 India |
| Phone |
7266029938 |
| Fax |
|
| Email |
srivatsan.anu@gmail.com |
|
Details of Contact Person Scientific Query
|
| Name |
Dr Prithvishree Ravindra |
| Designation |
Additional Professor |
| Affiliation |
Kasturba Medical College, Manipal |
| Address |
Dept of Emergency Medicine, Kasturba Medical College, Tiger Circle Road, Madhav Nagar, Manipal, Karnataka 576104
Udupi KARNATAKA 576104 India |
| Phone |
9035296971 |
| Fax |
|
| Email |
prithvishree.r@manipal.edu |
|
Details of Contact Person Public Query
|
| Name |
Dr Prithvishree Ravindra |
| Designation |
Additional Professor |
| Affiliation |
Kasturba Medical College, Manipal |
| Address |
Dept of Emergency Medicine, Kasturba Medical College, Tiger Circle Road, Madhav Nagar, Manipal, Karnataka 576104
Udupi KARNATAKA 576104 India |
| Phone |
9035296971 |
| Fax |
|
| Email |
prithvishree.r@manipal.edu |
|
|
Source of Monetary or Material Support
|
| Indian Council of Medical Research- STS Grant
Address: V. Ramalingaswami Bhawan, Ansari Nagar, New Delhi - 110029, India |
|
|
Primary Sponsor
|
| Name |
Anushka Srivatsan |
| Address |
Kasturba Medical College, Tiger Circle Road, Madhav Nagar, Manipal, Karnataka 576104. |
| Type of Sponsor |
Other [self] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Prithvishree Ravindra |
Kasturba Medical College and Kasturba Hospital, Manipal |
CT Room, Ground Floor, Department of Radiodiagnosis, Kasturba Medical College and hospital, Manipal, Karnataka 576104 Udupi KARNATAKA |
9035296971
prithvishree.r@manipal.edu |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Kasturba Medical College and Kasturba Hospital Institutional Ethics Committee-2 (Student Research) |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: I998||Other disorder of circulatory system, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
NIL |
NIL |
| Comparator Agent |
Nil |
Nil |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
99.00 Year(s) |
| Gender |
Both |
| Details |
Patients undergoing CT Coronary angiogram as per physician discretion for any indication |
|
| ExclusionCriteria |
| Details |
Patients with anatomical abnormalities in the chest, trauma induced deformities of chest, pulmonary or heart structural deformities as interpreted by radiologist. |
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
| Heart Compression Fraction achieved at standard chest compression depths across four BMI categories as determined by CT Coronary Angiography. |
Assessed after complete collection of data as per sample size. |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| Optimal Chest Compression Point identified across four BMI categories using CT Coronary Angiogram |
At time of CT Coronary Angiogram |
|
|
Target Sample Size
|
Total Sample Size="304" Sample Size from India="304"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
08/12/2025 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="3" Months="2" Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Yet Recruiting |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Participants will include patients presenting to Kasturba Hospital after obtaining Institutional Ethics Committee approval. Those undergoing CT Coronary Angiography at the discretion of their physician will be screened for eligibility according to predefined inclusion and exclusion criteria.
After obtaining written informed consent, demographic and anthropometric data will be recorded.
BMI categories for this study are defined as per WHO guidelines.
On CT CAG imaging, two primary parameters will be documented, which are Optimal Chest Compression Point, OCCP, and the Heart Compression Fraction, HCF.
OCCP is identified on the diastolic image showing the maximum compressible areas of both ventricles without the Left Ventricular Outflow Tract being visible.
At the OCCP level, the internal anteroposterior chest diameter and maximum heart AP diameter will be measured to calculate the HCF.
The vertical distance from the xiphisternum’s lower edge to the OCCP will be recorded.
For each participant, the heart anteroposterior diameter will be recorded as the end-diastolic value, while the difference between the internal chest diameter and the proposed Chest Compression Depth will represent the end-systolic value. The Heart Compression Fraction, a modified form of the ejection fraction, will indicate the proportion of the heart compressed at the proposed CCD. Residual depth will be determined by subtracting the proposed CCD from the internal AP chest diameter. Interpretation of values will classify an HCF of 20 percent or more as optimal compression, less than 20 percent as under compression, and a residual depth of less than 2 cm as over compression. The distance between the xiphisternum and the Optimal Chest Compression Point will be used to identify the most effective location for chest compressions. After complete data collection, OCCP and HCF values will be compared across different BMI categories to evaluate their variation with body habitus and to determine the optimal chest compression depth and point for each BMI group. Radiological parameters, including OCCP and HCF, will therefore be comprehensively assessed and analysed across all BMI categories. |