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CTRI Number  CTRI/2025/11/098159 [Registered on: 27/11/2025] Trial Registered Prospectively
Last Modified On: 26/11/2025
Post Graduate Thesis  No 
Type of Trial  Observational 
Type of Study   Cross Sectional Study 
Study Design  Single Arm Study 
Public Title of Study   Studying chest and heart measurements using CT scans to find the best spot and depth for effective heart compressions during cardiac care 
Scientific Title of Study   Radiological Assessment of Optimal Chest Compression Point and Achievable Compression Depth for CPR across various BMI Categories in Indian Population using CT Coronary Angiography 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Anushka Srivatsan 
Designation  MBBS Student-Primary Investigator 
Affiliation  Kasturba Medical College, Manipal 
Address  Kasturba Medical College, Tiger Circle Road, Madhav Nagar, Manipal, Karnataka 576104

Udupi
KARNATAKA
576104
India 
Phone  7266029938  
Fax    
Email  srivatsan.anu@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Prithvishree Ravindra 
Designation  Additional Professor 
Affiliation  Kasturba Medical College, Manipal 
Address  Dept of Emergency Medicine, Kasturba Medical College, Tiger Circle Road, Madhav Nagar, Manipal, Karnataka 576104

Udupi
KARNATAKA
576104
India 
Phone  9035296971  
Fax    
Email  prithvishree.r@manipal.edu  
 
Details of Contact Person
Public Query
 
Name  Dr Prithvishree Ravindra 
Designation  Additional Professor 
Affiliation  Kasturba Medical College, Manipal 
Address  Dept of Emergency Medicine, Kasturba Medical College, Tiger Circle Road, Madhav Nagar, Manipal, Karnataka 576104

Udupi
KARNATAKA
576104
India 
Phone  9035296971  
Fax    
Email  prithvishree.r@manipal.edu  
 
Source of Monetary or Material Support  
Indian Council of Medical Research- STS Grant Address: V. Ramalingaswami Bhawan, Ansari Nagar, New Delhi - 110029, India 
 
Primary Sponsor  
Name  Anushka Srivatsan 
Address  Kasturba Medical College, Tiger Circle Road, Madhav Nagar, Manipal, Karnataka 576104.  
Type of Sponsor  Other [self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Prithvishree Ravindra  Kasturba Medical College and Kasturba Hospital, Manipal  CT Room, Ground Floor, Department of Radiodiagnosis, Kasturba Medical College and hospital, Manipal, Karnataka 576104
Udupi
KARNATAKA 
9035296971

prithvishree.r@manipal.edu 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Kasturba Medical College and Kasturba Hospital Institutional Ethics Committee-2 (Student Research)  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: I998||Other disorder of circulatory system,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  NIL  NIL 
Comparator Agent  Nil  Nil 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  99.00 Year(s)
Gender  Both 
Details  Patients undergoing CT Coronary angiogram as per physician discretion for any indication 
 
ExclusionCriteria 
Details  Patients with anatomical abnormalities in the chest, trauma induced deformities of chest, pulmonary or heart structural deformities as interpreted by radiologist. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Heart Compression Fraction achieved at standard chest compression depths across four BMI categories as determined by CT Coronary Angiography.  Assessed after complete collection of data as per sample size. 
 
Secondary Outcome  
Outcome  TimePoints 
Optimal Chest Compression Point identified across four BMI categories using CT Coronary Angiogram  At time of CT Coronary Angiogram 
 
Target Sample Size   Total Sample Size="304"
Sample Size from India="304" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   08/12/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="3"
Months="2"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Participants will include patients presenting to Kasturba Hospital after obtaining Institutional Ethics Committee approval. Those undergoing CT Coronary Angiography at the discretion of their physician will be screened for eligibility according to predefined inclusion and exclusion criteria.

After obtaining written informed consent, demographic and anthropometric data will be recorded. 

BMI categories for this study are defined as per WHO guidelines.

On CT CAG imaging, two primary parameters will be documented, which are Optimal Chest Compression Point, OCCP, and the Heart Compression Fraction, HCF.
OCCP is identified on the diastolic image showing the maximum compressible areas of both ventricles without the Left Ventricular Outflow Tract being visible.

At the OCCP level, the internal anteroposterior chest diameter and maximum heart AP diameter will be measured to calculate the HCF.

The vertical distance from the xiphisternum’s lower edge to the OCCP will be recorded.


For each participant, the heart anteroposterior diameter will be recorded as the end-diastolic value, while the difference between the internal chest diameter and the proposed Chest Compression Depth will represent the end-systolic value. The Heart Compression Fraction, a modified form of the ejection fraction, will indicate the proportion of the heart compressed at the proposed CCD. Residual depth will be determined by subtracting the proposed CCD from the internal AP chest diameter. Interpretation of values will classify an HCF of 20 percent or more as optimal compression, less than 20 percent as under compression, and a residual depth of less than 2 cm as over compression. The distance between the xiphisternum and the Optimal Chest Compression Point will be used to identify the most effective location for chest compressions. After complete data collection, OCCP and HCF values will be compared across different BMI categories to evaluate their variation with body habitus and to determine the optimal chest compression depth and point for each BMI group. Radiological parameters, including OCCP and HCF, will therefore be comprehensively assessed and analysed across all BMI categories.

 
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