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CTRI Number  CTRI/2025/12/098392 [Registered on: 03/12/2025] Trial Registered Prospectively
Last Modified On: 29/11/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Other (Specify) [occupational therapy ]  
Study Design  Single Arm Study 
Public Title of Study   Movement re-training Program with regular Occupational Therapy: A Way to Improve Arm Function in Patients with Brain Tumours having arm, hand weakness. 
Scientific Title of Study   A Prospective Interventional Study on the Effectiveness of the Motor Relearning Program Combined with Conventional Occupational Therapy in Improving Hemiparetic Upper Limb Function in Patients with Brain Tumours 
Trial Acronym  NOT APPLICABLE  
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Manjusha Vagal 
Designation  Professor and Office In-Charge, Occupational therapy department  
Affiliation  Tata Memorial Hospital and Research Centre 
Address  Occupational Therapy department 94 Main Building Ground floor,Tata Memorial Hospiatal Parel mumbai.
Occupational Therapy department 94 Main Building Ground floor,Tata Memorial Hospiatal Parel mumbai.
Mumbai (Suburban)
MAHARASHTRA
400012
India 
Phone  9867552266  
Fax    
Email  vagalmanjusha@yahoo.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Tina Parkar 
Designation  PG Student 
Affiliation  Tata Memorial Hospital and Research Centre 
Address  Occupational Therapy department 94 Main Building Ground floor,Tata Memorial Hospiatal Parel mumbai.
Occupational Therapy department 94 Main Building Ground floor,Tata Memorial Hospiatal Parel mumbai.
Mumbai
MAHARASHTRA
400012
India 
Phone  9773792224  
Fax    
Email  tinaparkar8@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Tina Parkar 
Designation  PG Student 
Affiliation  Tata Memorial Hospital and Research Centre 
Address  Occupational Therapy department 94 Main Building Ground floor,Tata Memorial Hospiatal Parel mumbai.
Occupational Therapy department 94 Main Building Ground floor,Tata Memorial Hospiatal Parel mumbai.
Mumbai
MAHARASHTRA
400012
India 
Phone  9773792224  
Fax    
Email  tinaparkar8@gmail.com  
 
Source of Monetary or Material Support  
TATA MEMORIAL HOSPITAL ,PAREL MUMBAI  
 
Primary Sponsor  
Name  NOT APPLICABLE  
Address  NOT APPLICABLE  
Type of Sponsor  Research institution 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 2  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Manjusha Vagal  Tata Memorial Hospital   Room number 94, Main building, Occupational Therapy Department, Tata Memorial Hospital, Parel 12, Mumbai, Maharashtra. Dr. E Borges Road, Parel, Mumbai-400012
Mumbai
MAHARASHTRA 
9867552266

vagalmanjusha@yahoo.com 
DR TINA PARKAR  Tata Memorial Hospital   Room number 94, Main building, Occupational Therapy Department, Tata Memorial Hospital, Parel 12, Mumbai, Maharashtra. Dr. E Borges Road, Parel, Mumbai-400012
Mumbai
MAHARASHTRA 
09773792224

tinaparkar8@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
INSTITUTIONAL ETHICS COMMITTEE- II  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: G978||Other intraoperative and postprocedural complications and disorders of nervous system,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  motor relearning program   a scientifically-grounded, task-oriented intervention based on principles of movement science, neuroscience, and motor learning 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  75.00 Year(s)
Gender  Both 
Details  1)Brain Tumors patients presenting with Hemiparesis.
2)Hemiparetic upper limb with Brunnstrom stage 2 and above.
3)Patients treated with Surgery, with or without Radiation therapy and Chemotherapy .
4)Age range - 18 to 75.
5)Both male and female .
6)Patient able to follow verbal commands.
7)Patient able to understand Hindi , Marathi or English language .
8)Patients having smart phone 
 
ExclusionCriteria 
Details  Patients with Apraxia .
• Premorbid Neuromuscular disorder ( Traumatic Brain Injury , Parkinson's etc ).
• Patients with involuntary movements 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
1)The Jebsen-Taylor Hand Function Test to evaluate changes in fine and gross motor skills of
the hand.
2)The Canadian Occupational Performance Measure to capture changes in functional
participation .
3)The Fugl-Meyer Assessment to measure improvements in motor and sensory recovery of
the upper limb. 
4 weeks  
 
Secondary Outcome  
Outcome  TimePoints 
nil  nil 
 
Target Sample Size   Total Sample Size="57"
Sample Size from India="57" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   05/11/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="8"
Days="15" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Many people who will undergo treatment for brain tumours—such as surgery, radiation, or chemotherapy—may experience weakness or reduced control in one side of body including upper limb and hand known as hemiparesis. Hemiparesis cause difficulties in performing daily tasks like dressing, eating, or writing.

We propose to carry out a prospective interventional study aiming at finding out whether a special therapy approach called the ‘Motor Relearning Program (MRP)’—when combined with regular ‘Occupational therapy’ over the period of four week for patients, male or female, of age group 18 to 75 treated for or undergoing treatment for brain tumor presenting with hemiparesis, can help improve arm movement and function. A total of 57 participants will be included in the study.

Each participant will receive two therapy sessions per week for one month, delivered by trained Occupational therapists.The therapy will focus on helping them re-learn how to use their affected arm through guided practice of everyday tasks, feedback, and goal-setting. The research team will assess the participants’ arm function and ability to perform daily activities before and after the therapy program using standard measurement tools like Jebson Taylor Hand Function test , COPM and Fugl Myer assessment . By comparing the pre and post results, they will determine whether the combination of therapies leads to improved movement and greater independence in brain tumour patient presenting with hemiparetic upper limb .This study will aim to provide better rehabilitation strategies that could help people with brain tumours regain their independence and improve their quality of life.

 
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