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CTRI Number  CTRI/2026/04/108738 [Registered on: 20/04/2026] Trial Registered Prospectively
Last Modified On: 19/04/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Surgical/Anesthesia 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Comparative evaluation of longitudinal axis and longitudinal oblique axis approaches for ultrasound guided radial artery cannulation in adults- A Randomised control study at a tertiary care centre 
Scientific Title of Study   Comparative evaluation of longitudinal axis and longitudinal oblique axis approaches for ultrasound guided radial artery cannulation in adults- A randomised controlled study at a tertiary care centre 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Nidhi G Yalagachin 
Designation  Junior Resident 
Affiliation  Karnataka Medical College and Research Institute Hubballi 
Address  Matru Krupa, 1/11A, Jayanagar, Vidyanagar, Hubli, Karnataka, India 580021
Department of Anaesthesia, Room number 206, KMCRI PB road, Vidyanagar Hubballi Karnataka 580021
Dharwad
KARNATAKA
580021
India 
Phone  8660319093  
Fax    
Email  nidhi2301yalagachin@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Prema Raddi 
Designation  Associate Professor 
Affiliation  Karnataka Medical College and Research Institute Hubballi 
Address  Department of Anaesthesia, Room number 206, KMCRI PB road, Vidyanagar Hubballi Karnataka

Dharwad
KARNATAKA
580021
India 
Phone  9886584315  
Fax    
Email  drpremavijay@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Prema Raddi 
Designation  Associate Professor 
Affiliation  Karnataka Medical College and Research Institute Hubballi 
Address  Department of Anaesthesia, Room number 206, KMCRI PB road, Vidyanagar Hubballi Karnataka

Dharwad
KARNATAKA
580021
India 
Phone  9886584315  
Fax    
Email  drpremavijay@gmail.com  
 
Source of Monetary or Material Support  
Karnataka Medical College and Research Institute, Department of Ananesthesiology, Room number 206, IP building division, PB road, Vidyanagar, Hubballi, Karnataka, India - 580021 
 
Primary Sponsor  
Name  Dr Nidhi G Yalagachin 
Address  Karnataka Medical College and Research Institute, Department of Anaesthesiology, Room number 206, KMCRI PB road, Vidyanagar Hubballi Karnataka 580021 
Type of Sponsor  Government medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Nidhi G Yalagachin  Karnataka Medical College and Research Institute Hubballi  Karnataka Medical College and Research Institute Hubballi, Department of Anaesthesiology, Room number 206, IP building, KMCRI PB road, Vidyanagar Hubballi Karnataka 580021
Dharwad
KARNATAKA 		 8660319093

nidhi2301yalagachin@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
KARNATAKA MEDICAL COLLEGE AND RESEARCH INSTITUTE HUBBALLI ETHICS COMMITTEE  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: 8||Other Procedures,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Ultrasound guided Radial artery cannulation- Longitudinal Group  Once the patient is selected based on the inclusion criteria, standard ASA monitors are attached to the patient. The arm is placed on an arm rest in slight abduction and dorsiflexion (30°– 45°), by placing a support roll under the dorsal aspect of wrist and secured using tape. Under strict aseptic precautions, cannulation is done under ultrasound guidance with GE Healthcare LOGIQ V1 AND LOGIQ V2 ultrasound using a linear array transducer probe (6–13 Hz) and a PUR ART-CAN arterial catheter. In both the groups, the USG probe will first be placed perpendicular to the artery. Artery will be identified by a circular anechoic pulsatile structure, which will be confirmed by Doppler and pulse wave. The anteroposterior diameter of the artery will then be measured following which the probe will be rotated by 90° to place it parallel to the course of artery, making it the ‘longitudinal axis- Group A. Local anaesthetic will be injected and the artery will be pierced at an angle of 30-45 degrees to the skin under real- time guidance at the midpoint of the short axis of the probe. Once a flash of blood is seen, the cannula will be lowered to 10-15 degrees and then advanced by 2-3 mm more into the artery and then connected to a pressure transducer. Successful cannulation will be confirmed by pressure waveform on the monitor. 
Comparator Agent  Ultrasound guided Radial artery cannulation- Longitudinal oblique group  The second group B. The arm is placed on an arm rest in slight abduction and dorsiflexion (30°– 45°), by placing a support roll under the dorsal aspect of wrist and secured using tape. Under strict aseptic precautions, cannulation is done under ultrasound guidance with GE Healthcare LOGIQ V1 AND LOGIQ V2 ultrasound using a linear array transducer probe (6–13 Hz) and a PUR ART-CAN arterial catheter For group B, after the identification the radial artery by using the same technique as used for group A, the probe (after keeping parallel to the artery) will be rotated by an angle of 15-20 degrees (clockwise on right hand and anticlockwise on the left). In this position, the artery is identified as an ‘elliptical’ (in contrary to circular in group A), anechoic pulsatile structure, which will be confirmed by Doppler and pulse wave. Local anaesthetic will be injected and the artery will be pierced at an angle of 30-45 degrees to the skin under real- time guidance at the midpoint of the short axis of the probe. Once a flash of blood is seen, the cannula will be lowered to 10-15 degrees and then advanced by 2-3 mm more into the artery and then connected to a pressure transducer. Successful cannulation will be confirmed by pressure waveform on the monitor.  
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  65.00 Year(s)
Gender  Both 
Details  • Age 18- 65 years
• American Society of Anesthesiologists [ASA] physical status classification I and II.
• Patients with valid informed consent 
 
ExclusionCriteria 
Details  • Patients with negative modified Allen’s test
• Patients with Peripheral Vascular Disease
• Patients with burns, infection at the site of insertion
• Patients in hypovolemic shock
 
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Alternation 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
To assess and compare the first pass success rates in longitudinal approach (LA) and longitudinal oblique approach (LOA) using ultrasound guidance for radial artery cannulation.  Time to cannukate will be taken from the point of identification of the artery to the waveforms on the monitor 
 
Secondary Outcome  
Outcome  TimePoints 
To assess & compare the time of cannulation, failure rates & complications between the two groups- longitudinal approach (LA) & longitudinal oblique approach (LOA) using ultrasound guidance for radial artery cannulation.  Total cannulation time is calculated from identification of artery on the probe to waveforms on the monitor. patients will be observed for 48 hour for complications like hematoma, thrombosis or infection 
 
Target Sample Size   Total Sample Size="100"
Sample Size from India="100" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   30/04/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - YES
  1. What data in particular will be shared?
    Response - All of the individual participant data collected during the trial, after de-identification.

  2. What additional supporting information will be shared?
    Response - Informed Consent Form

  3. Who will be able to view these files?
    Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.

  4. For what types of analyses will this data be available?
    Response - To achieve aims in the approved proposal.

  5. By what mechanism will data be made available?
    Response (Others) - 

  6. For how long will this data be available start date provided 01-11-2025 and end date provided 01-11-2026?
    Response - Immediately following publication. No end date.

  7. Any URL or additional information regarding plan/policy for sharing IPD? 
    Additional Information - NIL
Brief Summary   Arterial cannulation is an invasive procedure which is done in operating theatres and intensive care units (ICU) for beat to beat hemodynamic monitoring and to assess fluid responsiveness. Classically, arterial cannulation is performed by digital palpation technique. However, due to anatomical variations, cannulation by landmark technique may not always be successful. With the advent of ultrasonography, the rate of successful cannulation has increased significantly. Also, ultrasound guidance reduces the number of needle passes, time to cannulate and the incidence of associated complications. – (like hematoma formation, injuring the adjacent vein or nerve or other surrounding structures). 
USG- guided radial artery cannulation has been conventionally done by two approaches: a) Transverse/out-of-plane approach, b) Longitudinal/in-plane approach 
The present study is undertaken to compare the success of arterial cannulation of the radial artery using ultrasound in LA and LOA. Our primary objective is to assess the success of cannulation in the first attempt, while the secondary objective is to assess the number of attempts, failure rate, total cannulation time and associated complications. Patients will be observed for the next 48 h for complications like hematoma, thrombosis, or infection.


 
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