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CTRI Number  CTRI/2026/01/100516 [Registered on: 08/01/2026] Trial Registered Prospectively
Last Modified On: 07/01/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Surgical/Anesthesia 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Effect of sitting for one minute and two minutes with immediately lying down after spinal anaesthesia on blood pressure in below waist surgeries. 
Scientific Title of Study   Comparison of one minute and two minute sitting position with immediately lying down on hypotension after subarachnoid block in elective infra umbilical surgeries 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  Other 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Thushar P N 
Designation  PG resident  
Affiliation  Ramaiah medical college  
Address  Department of Anaesthesiology Ramaiah Medical College MSRIT Post Bangalore

Bangalore
KARNATAKA
560054
India 
Phone  8762341714  
Fax    
Email  tusharnayak007@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Prapti Rath 
Designation  Associate professor  
Affiliation  Ramaiah Medical College  
Address  Department of Anaesthesiology Ramaiah Medical College MSRIT Post Bangalore 560054

Bangalore
KARNATAKA
560054
India 
Phone  8197007915  
Fax    
Email  praps1985@gmail.com  
 
Details of Contact Person
Public Query  
Name  Thushar P N  
Designation  PG Resident  
Affiliation  Ramaiah Medical College  
Address  Department of Anaesthesiology Ramaiah Medical College MSRIT Post Bangalore 560054

Bangalore
KARNATAKA
560054
India 
Phone  8762341714  
Fax    
Email  tusharnayak007@gmail.com  
 
Source of Monetary or Material Support  
Ramaiah medical college MSRIT post Bangalore 560054 Karnataka India 
 
Primary Sponsor  
Name  Ramaiah medical college  
Address  New BEL road MSRIT post Bangalore 560054 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Thushar P N  Ramaiah Medical College Hospital   Department of Anaesthesiology 2nd floor D block Teaching hospital MSRIT Post Bangalore Karnataka 560054
Bangalore
KARNATAKA 		 8762341714

tusharnayak007@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
MS Ramaiah Medical College Ethics Committee   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M161||Unilateral primary osteoarthritisof hip, (2) ICD-10 Condition: M171||Unilateral primary osteoarthritisof knee, (3) ICD-10 Condition: M170||Bilateral primary osteoarthritis of knee, (4) ICD-10 Condition: M165||Unilateral post-traumatic osteoarthritis of hip, (5) ICD-10 Condition: M173||Unilateral post-traumatic osteoarthritis of knee, (6) ICD-10 Condition: M172||Bilateral post-traumatic osteoarthritis of knee, (7) ICD-10 Condition: M201||Hallux valgus (acquired), (8) ICD-10 Condition: M203||Hallux varus (acquired), (9) ICD-10 Condition: M214||Flat foot [pes planus] (acquired), (10) ICD-10 Condition: M216||Other acquired deformities of foot, (11) ICD-10 Condition: N210||Calculus in bladder, (12) ICD-10 Condition: N201||Calculus of ureter, (13) ICD-10 Condition: N209||Urinary calculus, unspecified, (14) ICD-10 Condition: N401||Benign prostatic hyperplasia withlower urinary tract symptoms, (15) ICD-10 Condition: N430||Encysted hydrocele, (16) ICD-10 Condition: N434||Spermatocele of epididymis, (17) ICD-10 Condition: N471||Phimosis, (18) ICD-10 Condition: N472||Paraphimosis, (19) ICD-10 Condition: N810||Urethrocele, (20) ICD-10 Condition: N811||Cystocele, (21) ICD-10 Condition: N813||Complete uterovaginal prolapse, (22) ICD-10 Condition: N813||Complete uterovaginal prolapse, (23) ICD-10 Condition: N815||Vaginal enterocele, (24) ICD-10 Condition: N816||Rectocele, (25) ICD-10 Condition: N820||Vesicovaginal fistula, (26) ICD-10 Condition: N821||Other female urinary-genital tractfistulae, (27) ICD-10 Condition: O||Medical and Surgical,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Patient will be made to lay down immediately after subarachnoid block  Patients will be made to lay down immediately after subarachnoid block. 
Comparator Agent  Sitting position for one minute and two minutes after subarachnoid block  Patients will be made to sit for 1 minute and 2 minute after subarachnoid block before making them lay down.  
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  All elective infra umbilical surgeries.
ASA grade I and II 
 
ExclusionCriteria 
Details  Spine deformity.
Previous lumbar spine surgery.
Ankylosing spondylitis.
Rheumatoid arthritis.
Pregnancy.
ASA grade III and IV.
Absolute contraindication for subarachnoid block.
Patients on beta blockers, calcium channel blockers.
Height lesser than 150 cms. 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Other 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Hypotension after subarachnoid block in immediately lying down, lying down after one minute sitting position and lying down after two minutes sitting position groups. Parameters such as heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, oxygen saturation of blood will be measured.  Time in minutes,
At One minute for first ten minutes, every two minutes for next ten minutes, for every five minutes till the end of surgery. 
 
Secondary Outcome  
Outcome  TimePoints 
To evaluate the highest level of sensory block in all three groups.
To determine the time taken to reach highest sensory block in all three groups.
To determine the ephedrine requirements in all three groups. 		 Time in seconds for sensory block and motor block. 
 
Target Sample Size   Total Sample Size="123"
Sample Size from India="123" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   18/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="2"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   Subarachnoid block is the most commonly employed technique for infra umbilical surgeries. It is widely accepted due to its ease of administration, reliability and rapid onset.
However, hypotension is one of the most common and inevitable complication which occurs immediately after subarachnoid block owing to high intrathecal spread. Incidence of hypotension in normal population is 16 to 33 percent. Various preventive measures have been attempted to reduce incidence of hypotension namely delayed positioning technique, vasopressor addition, fluid preloading and co loading.
Delayed positioning technique in post subarachnoid block has shown to have better hemodynamic stability. Various studies have shown that patient who were positioned sitting post subarachnoid block for one minute, two minutes, three minutes and five minutes had less incidence of hypotension.
Allowing the patient to remain in sitting position for some time after subarachnoid block delays onset of action, decreased higher dermatomal spread and decreased incidence of hypotension.
 
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