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CTRI Number  CTRI/2026/03/107044 [Registered on: 30/03/2026] Trial Registered Prospectively
Last Modified On: 29/03/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Surgical/Anesthesia 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Comparing two local anaesthetics (ropivacaine and bupivacaine) for pain relief after keyhole knee surgery using a nerve block technique 
Scientific Title of Study   Comparison of postoperative analgesia by ropivacaine and bupivacaine for ultrasound-guided adductor canal block in arthroscopic knee surgery 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Rakshit Singh 
Designation  Post Graduate student 
Affiliation  ABVIMS and Dr. Ram Manohar Lohia Hospital, New Delhi 
Address  Room no.302,third floor, Department of Anaesthesia, ABVIMS and Dr.RML hospital New Delhi-110001 Delhi

New Delhi
DELHI
110093
India 
Phone  8826808052  
Fax    
Email  rakshitpunia6598@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Neha Gupta 
Designation  Professor  
Affiliation  ABVIMS and Dr. Ram Manohar Lohia Hospital, New Delhi 
Address  Room no. 302 3rd floor Department Of Anaesthesia ABVIMS and Dr. RML Hospital

New Delhi
DELHI
110001
India 
Phone  9899567234  
Fax    
Email  nehaguptadeuri@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Neha Gupta 
Designation  Professor  
Affiliation  ABVIMS and Dr. Ram Manohar Lohia Hospital, New Delhi 
Address  Room no. 302 3rd floor Department Of Anaesthesia ABVIMS and Dr. RML Hospital

New Delhi
DELHI
110001
India 
Phone  9899567234  
Fax    
Email  nehaguptadeuri@gmail.com  
 
Source of Monetary or Material Support  
ABVIMS and Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, Near Gurudwara Bangla Sahib, Connaught Place, New Delhi 110001 New Delhi 
 
Primary Sponsor  
Name  Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital 
Address  Department of Anaesthesia ABVIMS and Dr. RML Hospital New Delhi 110001 
Type of Sponsor  Government medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Rakshit Singh  ABVIMS and Dr RML Hospital  Room no 302, Third Floor,Department of Anaesthesia, ABVIMS and Dr RML Hospital, New Delhi, Delhi, India-110001
New Delhi
DELHI 
8826808052

rakshitpunia6598@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethics Committee ABVIMS and Dr RML Hospital  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M00-M99||Diseases of the musculoskeletal system and connective tissue,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Ultrasound-guided Adductor Canal Block  single injection of local anaesthetic into the adductor canal under ultrasound guidance for postoperative pain relief after arthroscopic knee surgery 
Intervention  Ultrasound-guided Adductor Canal Block with Bupivacaine  Single injection of 20 ml of 0.25% Bupivacaine in Adductor canal under ultrasound-guidance 
Intervention  Ultrasound-guided Adductor Canal Block with Ropivacaine  Single injection of 20 ml of 0.25% Ropivacaine in Adductor canal under ultrasound guidance 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  ASA physical status 1 or 2, scheduled for elective arthroscopic knee surgery under spinal anaesthesia  
 
ExclusionCriteria 
Details  Patients on chronic analgesic therapy
Coagulopathy
Infection at block site
Allergy to local anaesthetics
Polytrauma patients 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   On-site computer system 
Blinding/Masking   Participant and Investigator Blinded 
Primary Outcome  
Outcome  TimePoints 
Duration of postoperative analgesia i.e. time at which first rescue analgesic required i.e. when NRS at rest is more than 4  0,1,3,6,12,18 and 24 hours 
 
Secondary Outcome  
Outcome  TimePoints 
Total Dose of Rescue Analgesic required in first 24 hours   24 hours 
Quadriceps muscle strength using MMT Score  0,1,3,6,12,18 and 24 hours 
Adverse effects like local site hematoma and hemodynamic variations  0,1,3,6,12,18 and 24 hours 
 
Target Sample Size   Total Sample Size="72"
Sample Size from India="72" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 2/ Phase 3 
Date of First Enrollment (India)   10/04/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="3"
Days="7" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

This is a comparative interventional study to evaluate and compare the postoperative analgesia by ropivacaine and bupivacaine for ultrasound-guided adductor canal block in arthroscopic knee surgery. After obtaining Institutional Ethics Committee approval and written informed consent from patients, all patients meeting inclusion criteria will be enrolled in the study.

For adductor canal block, patient will be placed in supine position with knee slightly flexed on the side of surgery. A high frequency linear ultrasound transducer will be placed on the medial surface in midline of the thigh in the transverse plane. After visualisation of the pulsatile superficial femoral artery dorsal to the sartorial muscle, probe will be moved distally and saphenous nerve will be visualised as a hyperechoic structure anterolateral to the artery in subsartorial region. Using the in-plane technique, injection site will be confirmed with an injection of 5 ml of saline, and then 20 ml of 0.25% ropivacaine or 20 ml of 0.25% bupivacaine will be injected in Group R and Group B respectively.

After performing the block, hemodynamic parameters will be monitored and patient will be assessed for any adverse effects like local hematoma or any hemodynamic variations. In PACU, patient will be assessed at arrival and thereafter at 1, 3, 6 ,12, 18 and 24 hours for pain using Numerical Rating Scale(NRS) at rest and on movement. Injection tramadol 50 mg intravenous will be given as rescue analgesia when NRS at rest > 4. Time of requirement of first rescue analgesia and total dose of tramadol required in first 24 hours will be noted. Quadriceps muscle strength will be assessed using MMT Score(Manual Muscle Testing Score).

 
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