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CTRI Number  CTRI/2026/01/100731 [Registered on: 09/01/2026] Trial Registered Prospectively
Last Modified On: 08/01/2026
Post Graduate Thesis  No 
Type of Trial  Observational 
Type of Study   Cross Sectional Study 
Study Design  Single Arm Study 
Public Title of Study   A hospital-based study to screen young adults for early-onset colorectal cancer using stool tests and diet-lifestyle assessment 
Scientific Title of Study   A Hospital-Based Study on Early-onset colorectal cancer [EOCRC] screening using FIT test and dietary-lifestyle surveys in Central India 
Trial Acronym  NILL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Bhawna Sirohi 
Designation  Senior Consultant 
Affiliation  BALCO Medical Centre 
Address  Room No. 4,Medical Oncology OPD, Ground Floor, B Wing, Balco Medical Centre, Sector 36, Atal Nagar, PO Uparwara

Raipur
CHHATTISGARH
493661
India 
Phone  9756999976  
Fax    
Email  bhawna.sirohi@vedanta.co.in  
 
Details of Contact Person
Scientific Query
 
Name  Bhawna Sirohi 
Designation  Senior Consultant 
Affiliation  BALCO Medical Centre 
Address  Room No. 4,Medical Oncology OPD, Ground Floor, B Wing, Balco Medical Centre, Sector 36, Atal Nagar, PO Uparwara

Raipur
CHHATTISGARH
493661
India 
Phone  9756999976  
Fax    
Email  bhawna.sirohi@vedanta.co.in  
 
Details of Contact Person
Public Query
 
Name  Bhawna Sirohi 
Designation  Senior Consultant 
Affiliation  BALCO Medical Centre 
Address  Room No. 4,Medical Oncology OPD, Ground Floor, B Wing, Balco Medical Centre, Sector 36, Atal Nagar, PO Uparwara

Raipur
CHHATTISGARH
493661
India 
Phone  9756999976  
Fax    
Email  bhawna.sirohi@vedanta.co.in  
 
Source of Monetary or Material Support  
BALCO Medical Center, Sector 36, Atal Nagar, PO Uparwara, Raipur, Chhattisgarh, India 493661  
 
Primary Sponsor  
Name  Vedanta Medical Research Foundation  
Address  Balco Medical Centre, Sector 36, Atal Nagar, PO Uparwara, Raipur, Chhattisgarh, India 493661  
Type of Sponsor  Private hospital/clinic 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Bhawna Sirohi  BALCO Medical Centre  Room no 4, Medical Oncology,Ground floor, B wing, Sector 36, Atal Nagar, PO: Uparwara
Raipur
CHHATTISGARH 
9756999976

bhawna.sirohi@vedanta.co.in 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
BMC-IRB  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: C15-C26||Malignant neoplasms of digestive organs,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  50.00 Year(s)
Gender  Both 
Details  All participants who were newly registered and present with symptoms of early-onset colorectal cancer, and their first-degree relatives, will be included.
Participants above the age of 18 years and less than 50 years will be included
Participants who are willing to give a signed informed consent voluntarily
 
 
ExclusionCriteria 
Details  Participants aged less than 18 years and More than 50 years
Participants who are already treated or under treatment for colorectal cancer
Participants with an inability to provide informed consent.
 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Early detection of early onset of colorectal cancer screening among symptomatic patients and their first-degree relatives in a tertiary care centre in Chhattisgarh  February 2026 to July 2028 
 
Secondary Outcome  
Outcome  TimePoints 
NIL  NIL 
 
Target Sample Size   Total Sample Size="690"
Sample Size from India="690" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   19/01/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="3"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Open to Recruitment 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

The incidence of early-onset colorectal cancer (EOCRC) is increasing globally. A recent study from India showed that nearly one-third of new colorectal cancer cases occurred in young adults (<39 years), and a rising trend was observed in the incidence of lower gastrointestinal cancer cases. It is estimated that in the next 10 years, 25% of rectal cancers and 10–12% of CRC will be diagnosed in individuals younger than 50 years of age. In India, there has been an alarming rise in the incidence and deaths of EOCRC cases. EOCRC is particularly concerning due to younger patients being diagnosed at an advanced stage, aggressive nature and greater recurrence rates, all which leading to poor patient outcomes. There are many risk factors that lead to the development of early-onset colorectal cancer, including hereditary cancer syndromes, such as Lynch syndrome, obesity, diet, sedentary lifestyle, inflammatory bowel disease and altered microbiome. There were no established screening guidelines for colorectal cancer in India

Therefore Early onset of colorectal cancers screening among symptomatic patients and their first degree relatives in a tertiary care centre in Chhattisgarh.

A hospital-based prospective study will be conducted to assess the early onset of colorectal cancer among newly registered symptomatic young adults (<50 years) and their first degree relatives.

 
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