| CTRI Number |
CTRI/2026/02/103848 [Registered on: 13/02/2026] Trial Registered Prospectively |
| Last Modified On: |
13/02/2026 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Other (Specify) [Aerobic and resistance Training] |
| Study Design |
Randomized, Parallel Group Trial |
|
Public Title of Study
|
Effects of cardio and strength exercises on health indicators in people with a family history of high blood pressure |
|
Scientific Title of Study
|
Effect of combined aerobic and resistance training on autonomic
functions and exercise capacity in individuals with familial risk of hypertension |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Adila Parveen |
| Designation |
Assistant Professor |
| Affiliation |
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia |
| Address |
Room no 111, first floor, Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, New Delhi. South DELHI 110025 India
South
DELHI
110025
India
South
DELHI
110025
India |
| Phone |
8587868142 |
| Fax |
|
| Email |
aparveen1@jmi.ac.in |
|
Details of Contact Person
Scientific Query
|
| Name |
Namira Khan |
| Designation |
MPT Cardio student |
| Affiliation |
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia |
| Address |
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, New Delhi. South DELHI 110025 India
South
DELHI
110025
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia,
South
DELHI
110025
India |
| Phone |
9805876601 |
| Fax |
|
| Email |
nameirakhan1999@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Namira Khan |
| Designation |
MPT Cardio student |
| Affiliation |
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia |
| Address |
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, New Delhi. South DELHI 110025 India
South
DELHI
110025
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia,
South
DELHI
110025
India |
| Phone |
9805876601 |
| Fax |
|
| Email |
nameirakhan1999@gmail.com |
|
|
Source of Monetary or Material Support
|
| Centre for Physiotherapy and Rehabilitation sciences, Jamia Millia Islamia, Jamia Nagar , New Delhi-110025 |
|
|
Primary Sponsor
|
| Name |
Centre for Physiotherapy and Rehabilitation Sciences |
| Address |
Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia, New Delhi. South DELHI 110025 India |
| Type of Sponsor |
Other [Jamia Millia Islamia,New Delhi-110025] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Adila Parveen |
Jamia Millia Islamia |
Room No. 08 groundfloor, Centre for physiotherapy and rehabilitation sciences, Jamia Millia Islamia, New Delhi-110025, India
South
DELHI |
8587868142
aparveen1@jmi.ac.in |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional Ethics Committee, Jamia Millia Islamia, New Delhi-110025 |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Healthy Human Volunteers |
Family history of Hypertension |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Comparator Agent |
Control group |
This group will carry on with their usual activities. |
| Intervention |
Experimental group |
This group will perform supervised combined exercise training (aerobic and resistance exercises) three times per week for four weeks on non-consecutive days. Progression will be done by increasing the intensity that is 50-70% of 1RM in first two weeks and 60-80% of 1RM in last two weeks for resistance training, furthermore, 50-60% of HRR in first two weeks and 60-70% of HRR in last two weeks for aerobic training. |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
30.00 Year(s) |
| Gender |
Both |
| Details |
1. Individuals with systolic (SBP) and diastolic blood pressure (DBP) lower than 140/90 mmHg.
2. Individuals must have a father and/or a mother diagnosed with hypertension.
3. Individuals must be non-smokers.
4. Individuals in the normal range of body mass index (BMI) (18.5-24.9 kg/m2).
5. Subjects with low physical activity level, as defined by the International Physical Activity Questionnaire (IPAQ) classification.
|
|
| ExclusionCriteria |
| Details |
1. Individuals who are already diagnosed with hypertension, diabetes or other chronic disorders.
2. Individuals with any acute illness.
3. Individuals with musculoskeletal limitations to physical exercise.
4. Individuals with a history of chest pain and/or breathlessness.
5. Individuals who are current smokers and/ or have a history of alcohol consumption.
|
|
|
Method of Generating Random Sequence
|
Computer generated randomization |
|
Method of Concealment
|
Sequentially numbered, sealed, opaque envelopes |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
•Cardiac autonomic function
•Exercise capacity |
At baseline (before the start of intervention)
Post intervention (after 12 sessions) |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
•Heart rate recovery
•Blood pressure
•Physical activity |
At baseline (before the start of intervention)
Post intervention (after 12 sessions) |
|
|
Target Sample Size
|
Total Sample Size="44"
Sample Size from India="44"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
26/02/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0"
Months="2"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Open to Recruitment |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
This prospective pre-test–post-test study will evaluate the effect of combined aerobic and resistance training on cardiac autonomic function and exercise capacity in normotensive young adults (18–30 years) with a familial history of hypertension. Forty-four participants will be recruited and allocated into an experimental group or control group. The intervention group will perform supervised combined exercise training (aerobic treadmill walking and resistance exercises) three times per week for four weeks. The intensity of intervention will range from 50-70% of 1RM progressing up to 60-80% of 1RM for resistance training and 50-60% of HRR progressing up to 60-70% of HRR for aerobic training. The control group will continue usual activities. Baseline data including cardiac autonomic recovery (heart rate variability), exercise capacity (6-minute walk test), and heart rate recovery, blood pressure, physical activity will be collected one day before the intervention, and post-intervention measurements will be taken one day after completion of 12 sessions of training using standardized protocols. |