| CTRI Number |
CTRI/2025/11/096794 [Registered on: 03/11/2025] Trial Registered Prospectively |
| Last Modified On: |
25/10/2025 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Drug
Ayurveda
Preventive |
| Study Design |
Single Arm Study |
|
Public Title of Study
|
MANAGEMENT OF JWARA THROUGH JWARAHARA MAHAKASHAYA |
|
Scientific Title of Study
|
TO ASSESS THE EFFICACY OF JWARAHARA MAHAKASHAYA IN THE MANAGEMENT OF JWARA A CLINICAL STUDY |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
DR AYUSHI ALAWA |
| Designation |
MD SCHOLAR |
| Affiliation |
Govt. Ayurveda College Nipaniya Rewa MP |
| Address |
Dept of Samhita Siddhant Govt ayurveda college
nipaniya
REWA MP
Rewa
MADHYA PRADESH
486001
India
Rewa
MADHYA PRADESH
486001
India |
| Phone |
9770249941 |
| Fax |
|
| Email |
alawaarushi@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
DR AYUSHI ALAWA |
| Designation |
MD SCHOLAR |
| Affiliation |
Govt. Ayurveda College Nipaniya Rewa MP |
| Address |
Dept of Samhita Siddhant Govt ayurveda college
nipaniya
REWA MP
Rewa
MADHYA PRADESH
486001
India
Dept of Samhita Siddhant Govt ayurveda college
nipaniya
REWA MP
Rewa
MADHYA PRADESH
486001
India
Rewa
MADHYA PRADESH
486001
India |
| Phone |
9770249941 |
| Fax |
|
| Email |
alawaarushi@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Dr Pravanjan Acharya |
| Designation |
Professor and HOD |
| Affiliation |
Govt.Ayurveda College Nipaniya Rewa m.p |
| Address |
Dept of Samhita Siddhant Govt ayurveda college
nipaniya
REWA MP
Rewa
MADHYA PRADESH
486001
India
Dept of Samhita Siddhant Govt ayurveda college
nipaniya
REWA MP
Rewa
MADHYA PRADESH
486001
India
Rewa
MADHYA PRADESH
486001
India |
| Phone |
9827459956 |
| Fax |
|
| Email |
dr.pravanjan@gmail.com |
|
|
Source of Monetary or Material Support
|
|
|
Primary Sponsor
|
| Name |
Govt Ayurveda college nipaniya rewa MP |
| Address |
Govt Ayurveda college nipaniya rewa MP PIN CODE 486001 |
| Type of Sponsor |
Government medical college |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Ayushi Alawa |
Govt.Ayurveda College Nipaniya Rewa M.P |
Dept.of Samhita Siddhant Govt.ayurveda college nipaniya
rewa m.p
Rewa
MADHYA PRADESH
486001
India
Rewa
MADHYA PRADESH |
9770249941
alawaarushi@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional Ethics Committee Govt.Ayurveda college |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition:I999||Unspecified disorder of circulatory system. Ayurveda Condition: JVARAH, |
|
|
Intervention / Comparator Agent
|
| sno | Intervention/Comparator | Type | Drug-Type | Procedure Name | Details | | 1 | Intervention Arm | Drug | Classical | | (1) Medicine Name: JWARAHAR MAHAKASHYAY, Reference: Charak Sutra 4/36, Route: Oral, Dosage Form: Kwatha/ Kashaya, Dose: 50(ml), Frequency: bd, Bhaishajya Kal: Abhakta, Duration: 15 Days, anupAna/sahapAna: No, Additional Information: NIL |
|
|
|
Inclusion Criteria
|
| Age From |
16.00 Year(s) |
| Age To |
70.00 Year(s) |
| Gender |
Both |
| Details |
Patient of 16 to 70year
Temperature should be between 99 to 104 ºF
Patient of any gender who been diagnosed with a Jwara
Patient presenting with classical sign and symptoms of Jwara
Naveen Jwara and Vishama Jwara
Patient willing to sign the consent form
|
|
| ExclusionCriteria |
| Details |
Patient of less than 16 year to more than 70year
Temperature should be between 99 to 104 degree fahrenheit
Patient of any gender who been diagnosed with a Jwara
Patient presenting with classical sign and symptoms of Jwara
Naveen Jwara and Vishama Jwara
Patient willing to sign the consent form
|
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Open Label |
|
Primary Outcome
|
| Outcome |
TimePoints |
Improvement in subjective parameters like Fever
Anorexia Thirst Bodyache Uneasiness |
0 to 15 days |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
Improvement in subjective parameters like Fever
Anorexia Thirst Bodyache Uneasiness |
0 - 15 days |
|
|
Target Sample Size
|
Total Sample Size="50"
Sample Size from India="50"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
Phase 3 |
|
Date of First Enrollment (India)
|
30/04/2026 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="2"
Months="0"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
TITLE OF THE
RESEARCH WORK
TO ASSESS THE EFFICACY OF JWARAHARA MAHAKASHAYA IN THE
MANAGEMENT OF JWARA A CLINICAL STUDY In Ayurveda texts Jwara is a symptom of
various diseases but Acharyas mentioned it as individual disease.Acharya
Charaka mentioned Jwara as a Sarvaroga-agraj, and Sushruta
mentioned as Rogarat. Jwara is considered the most prominent
disease in Ayurveda and is referred to as rogapati jwara King of diseases Charak Chikitsa 3/26-27 This study aimed to assess the efficacy of JWARAHARA MAHAKASHAYA in JWARA Ayurveda literature according to mythology Jwara was originated from the hot & destructive breath
of Lord Shiva. An
imbalance State of Pachaka pitta leads Jwara which affect
physiology of body & produces Ama which ultimately leads to Jwara
condition.
DRUGS OF Jwarahara Mahakashaya ·
In Charaka Samhita Jwarahara
Mahakashaya is described in Shadvirechanshatashriya Adhyaya in Sutrasthana.
PROBABLE MODE OF ACTION: Antitoxic,
channel-purifying, and Vata-anulomaka (Vata-regulating)
antipyretic drugs such as Patha, Abhaya, Vibhitaka, Pilu, and Manjishtha.. Tissue-nourishing,
digestive fire-enhancing, channel-deobstructing, and Vata-anulomaka
antipyretic drugs such as Sariva, Sharkara, Draksha, Phalsa, and Amalaki.
TREATMENT REGIMEN: Drug Jwarahara Mahakshaya Form Kwatha Dose 50 ml BD Mode
of administration Oral intake Time
of administration Morning-evening Duration 7 days
Follow
up 15 days
|