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CTRI Number  CTRI/2025/06/089697 [Registered on: 27/06/2025] Trial Registered Prospectively
Last Modified On: 26/06/2025
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Other (Specify) [USING BLOOD PRODUCTS TO ENHANCE HEALING AFTER WISDOM TOOTH SURGERY]  
Study Design  Other 
Public Title of Study   A study on how using a blood product helps in faster healing after removing lower wisdom teeth 
Scientific Title of Study   Influence of concentrated growth factor CGF on short term clinical outcomes following the surgical removal of partially erupted mandibular third molars a prospective clinical study 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
nil  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Chaitya Adalja 
Designation  Post graduate student in department of oral and maxillofacial surgery 
Affiliation  KM Shah Dental Collage and Hospital Waghodia Vadodara- 391760 
Address  2 Department Of Oral And Maxillofacial Surgery KM Shah Dental Collage and Hospital Sumandeep Vidyapeeth Pipariya Waghodia 391760

Vadodara
GUJARAT
391760
India 
Phone  9687216320  
Fax    
Email  adaljachaitya@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Amit Mahajan 
Designation  Professor Department of Oral and Maxillofacial Surgery 
Affiliation  KM Shah Dental Collage and Hospital Sumandeep Vidyapeeth Pipariya Waghodia 391760 
Address  2 Department of Oral and Maxillofacial Surgery KM Shah Dental Collage and Hospital Sumandeep Vidyapeeth Pipariya Waghodia

Vadodara
GUJARAT
391760
India 
Phone  9924264787  
Fax    
Email  dramitmds@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr chaitya adalja 
Designation  Post graduate student in department of oral and maxillofacial surgery 
Affiliation  Km shah dental collage and hospital waghodia vadodara- 391760 
Address  2 Department of oral and maxillofacial surgery km shah dental collage and hospital sumandeep vidyapeeth pipariya waghodia

Vadodara
GUJARAT
391760
India 
Phone  9687216320  
Fax    
Email  adaljachaitya@gmail.com  
 
Source of Monetary or Material Support  
KM Shah dental collage and Hospital sumandeep vidyapeeth Pipariya Waghodia vadodara gujrat 391760 
 
Primary Sponsor  
Name  Dr Chaitya Adalja 
Address  2 Department of Oral and Maxillofacial Surgery KM Shah Dental Collage and Hospital Sumandeep Vidyapeeth Pipariya Waghodia vododara gujrat india 391760 
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
nil  nil 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr chaitya adalja  Km shah dental college and hospital sumandeep vidyapeeth vadodara gujrat   Room number 2 department of oral and maxillofacial surgery km shah dental college and hospital sumandeep vidyapeeth pipariya waghodia vadodara gujrat india 391760
Vadodara
GUJARAT 		 9687216320

adaljachaitya@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
sumandeep vidyapeeth institutional ethics committe  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  healthy human volunteers 
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Concentrated growth factor  Concentrated growth factor (CGF), a third-generation platelet concentrate which is helpful for healing process. This CGF will be placed in the socket after mandibular 3rd molar surgery. Then healing will be assessed at 3rd and 7th day postoperatively and study will be done for 14 patients within 6 months  
Comparator Agent  N/A  N/A 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  1 Patients having partially erupted mandibular 3rd molar
2 Patients american society of anaesthesiologist
classification will be I or II 
 
ExclusionCriteria 
Details  1 Patients not willing to participate in study
2 Patients with uncontrolled comorbidity and medically compromised
3 Patients diagnosed with coagulopathy
4 Patients with comorbid periodontitis gingivitis or oral infectious disease
5 Patients using hormone therapy in the last 6 month
 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
This study will help us to conclude effectiveness of using concentrated growth factor in 3rd molar surgery  This study will help us to conclude effectiveness of using concentrated growth factor in 3rd molar surgery at 1 week 
 
Secondary Outcome  
Outcome  TimePoints 
nil  nil 
 
Target Sample Size   Total Sample Size="14"
Sample Size from India="14" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   10/07/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Surgical extraction of third molar teeth is one of the most frequently performed procedures in oral surgery practice. Surgical extraction of third molars often results in pain, swelling, and trismus. While platelet concentrates like PRP and PRF have shown benefits in healing, limited research exists on concentrated growth factor (CGF), especially for partially erupted third molars. Concentrated growth factor (CGF), a third-generation platelet concentrate, has many advantages compared with first- and second-generation platelet concentrates, i.e., platelet-rich plasma (PRP) and platelet-rich fibrin (PRF). CGF is a new biomaterial discovered after platelet-rich plasma (PRP) and platelet rich fibrin (PRF), which contains a variety of high concentration growth factors and fibrin. As a concentrate from autologous blood, CGF can avoid the risk of immune rejection and can be safer and more economical than other fillers. This study aims to evaluate CGF’s effectiveness in reducing postoperative pain, swelling, and enhancing wound healing in 3rd molar surgeries.

 
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