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CTRI Number  CTRI/2025/08/093027 [Registered on: 13/08/2025] Trial Registered Prospectively
Last Modified On: 09/08/2025
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   A Study Comparing Two Training Methods to Improve Arm and Hand Function in Stroke Patients 
Scientific Title of Study   Comparison of Proprioceptive Neuromuscular Facilitation and Motor Relearning Programme on Upper Extremity Functional Recovery and Hand Function among Adults with Stroke in Brunnstrom Stage-II- A Randomized Controlled Trial 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Mohd Sajid Hussain 
Designation  PhD Scholar 
Affiliation  Galgotias University 
Address  Department of Physiotherapy Plot No.2, Sector 17-A Yamuna Expressway, Opposite Buddha International Circuit, Greater Noida, Gautam Buddh Nagar, Uttar Pradesh 203201

Gautam Buddha Nagar
UTTAR PRADESH
203201
India 
Phone  9897542410  
Fax    
Email  sajidhssn9@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr V Krishna Reddy 
Designation  Associate Professor 
Affiliation  Galgotias University 
Address  Department of Physiotherapy Plot No.2, Sector 17-A Yamuna Expressway, Opposite Buddha International Circuit, Greater Noida, Gautam Buddh Nagar, Uttar Pradesh 203201

Gautam Buddha Nagar
UTTAR PRADESH
203201
India 
Phone  7799233734  
Fax    
Email  v.reddy@galgotiasuniversity.edu.in  
 
Details of Contact Person
Public Query  
Name  Dr V Krishna Reddy 
Designation  Associate Professor 
Affiliation  Galgotias University 
Address  Department of Physiotherapy Plot No.2, Sector 17-A Yamuna Expressway, Opposite Buddha International Circuit, Greater Noida, Gautam Buddh Nagar, Uttar Pradesh 203201


UTTAR PRADESH
203201
India 
Phone  7799233734  
Fax    
Email  v.reddy@galgotiasuniversity.edu.in  
 
Source of Monetary or Material Support  
Galgotias University Department of Physiotherapy Plot No.2, Sector 17-A Yamuna Expressway, Opposite Buddha International Circuit, Greater Noida, Gautam Buddh Nagar, Uttar Pradesh 203201, India 
 
Primary Sponsor  
Name  Mohd. Sajid Hussain 
Address  Department of Physiotherapy Plot No.2, Sector 17-A Yamuna Expressway, Opposite Buddha International Circuit, Greater Noida, Gautam Buddh Nagar, Uttar Pradesh 203201 
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Arif Wahab  Alshifa Multispeciality Hospital  D 305, Physiotherapy Department, Room no. 25, Abul Fazal Enclave, Jamia Nagar, New Delhi 110025
South
DELHI 		 8588841181

drarifwahab@rediffmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
School Ethics Committee (GALGOTIAS UNIVERSITY)  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  Healthy Participants  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Conventional Technique  Group C will receive Conventional Technique Conventional therapy that includes active movements, strengthening to lower limb, trunk stability and balance exercise. Pre and post treatment assessment was done by using Upper extremity component of STREAM and Fugl-Meyer scale. Treatment will be given for 30 min, 4 days per week for 4 weeks. 
Intervention  Motor Relearning Program  Group B will receive Motor Relearning Program Training programme (specific motor task) to improve upper limb function, 1. To elicit muscle activity and train motor control for reaching and pointing. 2. To elicit muscle activity and train motor control for manipulation to train wrist extension. 3. To train palmer abduction and rotation of the thumb (opposition). 4. To train opposition of radial and ulnar sides of hand. 5. To train manipulations of objects. 6. To improve the use of holding objects for daily use  
Intervention  Proprioceptive Neuromuscular Facilitation  Group A participants will receive Proprioceptive Neuromuscular Facilitation (PNF) Technique For the upper extremities, we’ve got patterns that simulate reaching, grasping, and manipulating objects. These aren’t just random movements; they’re carefully crafted sequences that challenge the body in specific ways. For example, the D1 Flexion pattern might look like you’re trying to scratch your opposite ear, but it’s actually a complex movement that engages multiple muscle groups and joint movements. 
 
Inclusion Criteria  
Age From  45.00 Year(s)
Age To  65.00 Year(s)
Gender  Both 
Details  1. Age-45-65years
2. All genders.
3. Willingness to participate in study
4. Upper extremity weakness
5. Acute and Subacute
6. Able to understand and follow commands (MMSC Score more than or equal 24)
 
 
ExclusionCriteria 
Details  1. subject with cerebellar lession
2. dislocation or subluxated shoulder
3. contracture or deformity of the upper extremity
4. trauma or injury to upper extremity
5. chronic stroke
6. recurrent stroke 
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Alternation 
Blinding/Masking   Participant, Investigator and Outcome Assessor Blinded 
Primary Outcome  
Outcome  TimePoints 
1. Modified Ranking Scale
2. Upper Extremity Functional Scale
3. Grip and Pinch Strength  		 4 weeeks 
 
Secondary Outcome  
Outcome  TimePoints 
Upper Extremity Functional Recovery and Hand Function   4 weeks 
 
Target Sample Size   Total Sample Size="45"
Sample Size from India="45" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   15/09/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="1"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

The purpose of this study is to evaluate the effect of motor relearning programme and PNF on upper extremity functional recovery and hand function among adults with stroke in brunnstrom stage-II, Stroke often leads to significant upper extremity dysfunction, impairing independence and quality of life. While PNF and Motor Relearning Programs (MRP) both shine as rehabilitation methods for stroke patients, there’s really little direct evidence comparing which one works better for clients who have Stage II on the Brunnstrom scale. These folks struggle with not much voluntary movement, and use muscle patterns that get them into trouble. We’re going to find out some super cool evidence showing how these new techniques might really help hands work better, quality of life go up, make muscles stronger, balance improve and coordination become more slick.

 
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