FULL DETAILS (Read-only)  -> Click Here to Create PDF for Current Dataset of Trial
CTRI Number  CTRI/2025/05/087724 [Registered on: 27/05/2025] Trial Registered Prospectively
Last Modified On: 26/05/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Dentistry 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Comparison and assessment of two materials derived from patients own blood in treating bone defects around gums and teeth 
Scientific Title of Study   Evaluation of Titanium Platelet Rich Fibrin and Advanced Platelet Rich Fibrin in Treatment of Periodontal Intrabony Defects: A Cone Beam Computed Tomography Analysis 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
nil  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Iram khan  
Designation  post graduate student  
Affiliation  Institute of dental sciences Bareilly 
Address  Department of Periodontology Room no 228 Institute of Dental sciences Pilibhit bypass road Bareilly

Bareilly
UTTAR PRADESH
243006
India 
Phone  7500410078  
Fax    
Email  iramkhanbds2020@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Prerna Agarwal 
Designation  Professor 
Affiliation  INSTITUTE OF DENTAL SCIENCES BAREILLY 
Address  Department of Periodontology Institute of Dental Sciences Pilibhit Bypass Road Bareilly Uttar Pradesh 243006

Bareilly
UTTAR PRADESH
243006
India 
Phone  9927900055  
Fax    
Email  journalprerna@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Prerna Agarwal 
Designation  Professor 
Affiliation  INSTITUTE OF DENTAL SCIENCES BAREILLY 
Address  Department of Periodontology Institute Of Dental Sciences Pilibhit Bypass Road Bareilly Uttar Pradesh 243006

Bareilly
UTTAR PRADESH
243006
India 
Phone  9927900055  
Fax    
Email  journalprerna@gmail.com  
 
Source of Monetary or Material Support  
Institute Of Dental Sciences Bareilly Uttar Pradesh 243006 
 
Primary Sponsor  
Name  Institute of dental sciences Bareilly 
Address  Institute of Dental sciences Pilibhit Bypass road Bareilly Uttar Pradesh 243006 
Type of Sponsor  Other [Private Dental College] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Iram khan  Institute Of Dental Sciences Bareilly  DEPARTMENT OF PERIODONTICS ROOM NO 228 INSTITUTE OF DENTAL SCIENCES PILIBHIT BYPASS ROAD BAREILLY
Bareilly
UTTAR PRADESH 
07500410078

iramkhanbds2020@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
INSTITUTIONAL ETHICS COMMITTEE, IDS, BAREILLY, UP  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: K053||Chronic periodontitis,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Advanced Platelet Rich Fibrin  It is a type of platelet rich fibrin that contains higher concentration of leukocytes compared to standard PRF. It is said to be more refined version of PRF 
Intervention  Titanium Platelet Rich Fibrin  It is a platelet concentrate derived from blood prepared using titanium tubes to promote healing and bone regeneration 
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  55.00 Year(s)
Gender  Both 
Details  Individuals diagnosed with stage II or stage III periodontitis (AAP Classification of periodontitis 2017)
Age group of 20 to 55 years
Probing pocket depth more than equal to 5mm
Clinical attachment loss more than equal to 3mm
Radiographic evidence of intrabony defect 
 
ExclusionCriteria 
Details  Systemically compromised patients
Patients who are on medications that may impede wound healing
Patients who are smokers
Pregnant and lactating females 
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Alternation 
Blinding/Masking   Investigator Blinded 
Primary Outcome  
Outcome  TimePoints 
Mean gain in bone volume  baseline and 6 months 
 
Secondary Outcome  
Outcome  TimePoints 
pocket probing depth reduction
relative attachment level gain 
baseline and 6 months 
 
Target Sample Size   Total Sample Size="42"
Sample Size from India="42" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   10/06/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Periodontitis is a multifactorial disease characterized by the irreversible loss of connective tissue attachment and supporting alveolar bone. The ultimate goal pertaining to periodontal therapy is to control the active inflammation and the reconstruction of the structure lost due to periodontal disease. PRF stimulates the vascular system and promotes angiogenesis, releases growth factors such as vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), insulin-like growth factor (IGF), and transforming growth factor (TGF) that are involved in tissue regeneration. Although PRF has shown promising clinical results, some experts are worried about potential health risks because it uses glass evacuated collection tubes for blood with silica activators. Tunali M. et al. created a novel platelet concentrate in 2013 called titanium-prepared, platelet-rich fibrin (T-PRF). The preparation technique is predicated on the idea that titanium tubes, as opposed to the glass tubes utilized in Choukroun’s method, could be more successful at activating platelets. In 2014, Ghanaati et al. introduced a new modification called Advanced-PRF (A-PRF), which matrices in their solid form, utilizes a low-speed centrifugation protocol. This method offers the additional advantage of evenly distributed cells, promoting effective regeneration. Hence, this study is designed to compare and evaluate the effectiveness of T-PRF and A-PRP clinically and radiographically (using cone beam computed tomography) in the management of periodontal intrabony defects.

 
Close